Creatine in T Cell Antitumor Immunity and Cancer Immunotherapy
https://www.mdpi.com/2072-6643/13/5/1633
Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis
https://link.springer.com/protocol/10.1007/978-1-0716-1262-0_11#chapter-info
Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression
https://eprints.gla.ac.uk/273869/
https://www.samedaysupplements.com/cyclo-creation-by-alri-65-servings.html
Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
https://www.nature.com/articles/s41467-020-17181-w
Glutamine deficiency promotes recurrence and metastasis in colorectal cancer through enhancing epithelial–mesenchymal transition
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03523-3
Dietary change starves cancer cells, overcoming treatment resistance
Laboratory research finds a low-protein diet can enhance standard treatment for colon cancer
https://www.sciencedaily.com/releases/2022/11/221118130021.htm
These tiny bubbles are “warheads” for killing cancer
Researchers destroyed tumors in mice using low-frequency ultrasound and nanobubbles.
https://www.freethink.com/health/ultrasound-nanobubbles
Interaction of Zn with Losartan. Activation of Intrinsic Apoptotic Signaling Pathway in Lung Cancer Cells and Effects on Alkaline and Acid Phosphatases
https://link.springer.com/article/10.1007/s12011-018-1334-x
Severe COVID-19 is associated with molecular signatures of aging in the human brain
https://www.nature.com/articles/s43587-022-00321-w
Combination of niclosamide and current therapies to overcome resistance for cancer: New frontiers for an old drug
https://www.sciencedirect.com/science/article/pii/S0753332222011787
NAD+ Helps Natural Killer Cells to Fight Cancer
Cancer fighting requires cellular energy.
https://www.lifespan.io/news/nad-helps-natural-killer-cells-to-fight-cancer/
Can NMN Supplements Cause Cancer?
https://healthnews.com/longevity/longevity-supplements/can-nmn-supplements-cause-cancer/
Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination
https://link.springer.com/article/10.1007/s00392-022-02129-5
Viagra lowers risk of Alzheimer’s disease by 69%, study finds
https://boingboing.net/2022/12/12/viagra-lowers-risk-of-alzheimers-disease-by-69-study-finds.html
Dysregulated lipid synthesis by oncogenic IDH1 mutation is a targetable synthetic lethal vulnerability
Omicron BQ, XBB subvariants are a serious threat to boosters and knock out antibody treatments
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
https://www.cell.com/cell/fulltext/S0092-8674(22)01531-8
Potential Therapy for Metastatic Colon Cancer Identified in Preclinical Studies
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
https://www.sciencedirect.com/science/article/abs/pii/S1535610822005633
Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
https://link.springer.com/article/10.1186/s43556-022-00108-w
Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis
https://journals.asm.org/doi/full/10.1128/mbio.03024-22
Repurposing Disulfiram as an Antimicrobial Agent in Topical Infections
Colon cancer: Dying cancer cells give neighboring tumor cells instructions on how to survive
Researchers in Frankfurt, Germany, discover new mechanism of chemotherapy resistance in colon cancer
https://www.eurekalert.org/news-releases/971705
Potential Therapy for an Aggressive Type of Colon Cancer Identified in Preclinical Studies
Cancer treatments boosted by immune-cell hacking
Precision-controlled CAR-T-cell immunotherapies could be used to tackle a range of tumour types.
https://www.nature.com/articles/d41586-022-04465-y
The Link Between Severe COVID and Exercise Is Even Stronger Than We Thought
https://www.popsugar.co.uk/fitness/exercise-lower-risk-severe-covid-study-49043383
Ceritinib – Repurposed Drug Can Target Cancer Cells’ Shield Against Immune System
The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein
https://www.nature.com/articles/s41467-022-34065-3
Repurposing radiotherapy drugs could give immunotherapy a boost
Radical lupus treatment uses CAR T-cell therapy developed for cancer
Five people with the autoimmune condition lupus are now in remission after receiving a version of CAR-T therapy, which was originally developed for cancer
Losartan & Propranolol – Repurposing old drugs for new cancer treatments
https://www.dvm360.com/view/repurposing-old-drugs-for-new-cancer-treatments
Do fungi lurking inside cancers speed their growth?
Studies that scrutinized thousands of tumour samples provide the clearest link yet between cancer and fungi — but more research is needed.
https://www.nature.com/articles/d41586-022-03074-z
Ovarian cancer mutational processes drive site-specific immune evasion
https://www.nature.com/articles/s41586-022-05496-1
Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression
https://www.mdpi.com/2309-608X/7/4/250
Andrographis – Andrographolide, an Herbal Medicine, Inhibits Interleukin-6 Expression and Suppresses Prostate Cancer Cell Growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063649/
Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells
https://www.sciencedirect.com/science/article/abs/pii/S0006291X22012219
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer
https://www.sciencedirect.com/science/article/pii/S2213231722001987
Aspirin and celecoxib revealed anticancer and immunomodulatory effects on colon cancer cells
Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora
https://www.sciencedirect.com/science/article/abs/pii/S0944711322002963
Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers
https://www.mdpi.com/2072-6694/12/2/287
A substance in broccoli – Indole-3-carbinol in vitro antiviral activity against SARS-Cov-2 virus and in vivo toxicity
https://www.nature.com/articles/s41420-022-01280-2
Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression
https://www.jci.org/articles/view/158661
Population of “Cheating” Cancer Cells Identified by Researchers
Some cancer cells can “cheat” through escaping constraints imposed by lack of oxygen, allowing the cancer cells to continue to grow.
Gene therapy gel heals decades-old wounds in trial for blistering skin disease
Researchers find that a gel tested in patients with a life-threatening blistering skin disease helps wounds heal. The gel — the first topical gene therapy — awaits FDA approval.
https://med.stanford.edu/news/all-news/2022/12/epidermolysis-bullosa-gel.html
Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy
Combining vitamin C with antibiotics destroys cancer stem cells
https://www.medicalnewstoday.com/articles/317902
Diet, Microbiome, and Cancer Immunotherapy
https://www.mdpi.com/2072-6643/13/7/2217
Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)
https://pubmed.ncbi.nlm.nih.gov/31002656/
Ursolic acid: a natural modulator of signaling networks in different cancers
https://cancerci.biomedcentral.com/articles/10.1186/s12935-022-02804-7
New way of using DNA to kill cancer cells could pave the way for a cure, scientists say
- University of Tokyo scientists may have paved a way to use DNA to cure cancer
- Study author Professor Akimitsu Okamoto says their research is ‘good news’
- It uses a hair clip shaped, cancer-killing DNA, which is injected into cancer cells
Glioblastoma-Specific Epigenetic Mechanism Identified that Scuppers Tumor Suppressor
Repurposing Opportunities in Oncology: Using ‘Old’ Drugs as ‘Novel’ Anti-cancer Agents
Essential Oils as Novel Anthelmintic Drug Candidates
https://www.mdpi.com/1420-3049/27/23/8327
Off-Patent Liver Disease Drug Could Stop COVID-19 and Protect Against Future Variants
- Cambridge scientists have shown that a widely-used drug to treat liver disease can prevent SARS-CoV-2 infection or reduce COVID-19 severity
- The drug has minimal side effects, is cheap, and should protect against future variants of SARS-CoV-2
- Their unique study involved ‘mini-organs’, animal research, donated human organs, volunteers, and patients
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
https://www.nature.com/articles/s41586-022-05594-0
The Antineoplastic Effect of Carboplatin Is Potentiated by Combination with Pitavastatin or Metformin in a Chemoresistant High-Grade Serous Carcinoma Cell Line
https://www.mdpi.com/1422-0067/24/1/97
Repurposing Disulfiram as an Antimicrobial Agent in Topical Infections
https://nitro.download/view/615D338AD9DD0F6/Sanet.st_B09Q96R5F2_EBOK.pdf
Brand-new treatment stops tumor cells from ‘hiding’ and is being tested in the US
Population of “Cheating” Cancer Cells Identified by Researchers
Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-022-01591-3
Ceritinib – Repurposed Drug Can Target Cancer Cells’ Shield Against Immune System
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy
https://jitc.bmj.com/content/10/8/e004660
SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis
https://www.nature.com/articles/s41392-022-01239-w
Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells
https://synapse.koreamed.org/articles/1516079963
Pentoxifylline induces caspase-dependent apoptosis in colorectal cancer cells
https://www.sciencedirect.com/science/article/pii/S235291482200140X
Celecoxib promotes the efficacy of STING-targeted therapy by increasing antitumor CD8+ T-cell functions via modulating glucose metabolism of CD11b+Ly6G+ cells
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.34394
Metformin – An Old Diabetes Drug May Protect You Against Long COVID
https://www.thedailybeast.com/diabetes-drug-metformin-may-protect-you-against-long-covid
Study discovers triple immunotherapy combination as possible treatment for pancreatic cancer
Targeting T cells and myeloid cells together improved anti-tumor response and survival in preclinical models
https://www.eurekalert.org/news-releases/975440
How COVID Vaccines Cause Cancer
https://www.theepochtimes.com/health/how-covid-vaccines-cause-cancer_4952911.html
Propolis: The Role of Propolis in Cancer
https://www.ijvar.org/index.php/ijvar/article/view/548
Red Ginseng Extract and γ-Aminobutyric Acid Synergistically Enhance Immunity Against Cancer Cells and Antitumor Metastasis Activity
https://www.liebertpub.com/doi/abs/10.1089/jmf.2022.K.0079
Natural Killer Cell-Based Cancer Immunotherapy
https://www.intechopen.com/online-first/85341
Can exercise increase natural killer cell infiltration of the prostate?
https://bjui-journals.onlinelibrary.wiley.com/doi/full/10.1111/bju.15904
Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution
https://www.sciencedirect.com/science/article/abs/pii/S0006291X22017405
The Latest Approach of Immunotherapy with Endosomal TLR Agonists Improving NK Cell Function
https://www.mdpi.com/2227-9059/11/1/64
Potential of Compounds Originating from the Nature to Act in Hepatocellular Carcinoma Therapy by Targeting the Tumor Immunosuppressive Microenvironment
https://www.mdpi.com/1420-3049/28/1/195#
Tumor Microenvironment and Metabolism: Role of the Mitochondrial Melatonergic Pathway in Determining Intercellular Interactions in a New Dynamic Homeostasis
https://www.mdpi.com/1422-0067/24/1/311
An omega-3 that’s poison for tumors
https://www.sciencedaily.com/releases/2021/06/210611110802.htm
Seasonal coronavirus–specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19
https://www.jci.org/articles/view/150613
Chinese whistleblower claims first COVID outbreak was INTENTIONAL and happened in October 2019 at Military World Games in Wuhan – two months before China notified the world about virus
- Defector Wei Jingsheng said virus may have first spread at military tournament
- Reports emerged in October 2019 athletes at event fell ill with mystery sickness
- Mr Jingsheng alleged China deliberately spread virus during Military Games
- He claims he took his concerns to senior figures in the US gov but was ignored
Deutsche Ärztin heilt erstmals Long-Covid: „Es ist wie ein Riesen-Wunder“
Manathakkali holds hope for liver cancer patients
An RGCB team gets international patents for discovering compound with anti-cancer properties in its leaves
Ivermectin as a Broad-Spectrum Host-Directed Antiviral
https://www.mdpi.com/2073-4409/9/9/2100/htm
Cancer drug repurposed to treat malaria shown to be nearly 100% effective
Researchers discover how cholesterol feeds cancer metastasis
https://newatlas.com/medical/how-cholesterol-feeds-cancer-metastasis/
Page copies of the report, unsorted: modi-sars-pandemieplan2012.zip
Heparin’s COVID-19 Benefit Greatest in Moderately Ill Patients
https://www.medscape.com/viewarticle/956630
Ivermectin – Israeli scientist says COVID-19 could be treated for under $1/day
Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19
https://www.sciencedirect.com/science/article/pii/S2052297521000883
New drug combo shows early potential for treating pancreatic cancer
Researchers find three immunotherapy drugs given together can eliminate pancreatic tumors in mice.
https://news.mit.edu/2021/pancreatic-cancer-immunotherapy-cd155-0805
Exercise Improves Health Through Changes to DNA
A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status
Ivermectin and Doxycycline might present better clinical outcomes against COVID-19.•
Ivermectin might present as a prophylactic approach against COVID-19.•
Vitamin-D, Vitamin-C, Zinc, and cannabidiol combination boost immunity.
https://www.sciencedirect.com/science/article/pii/S0753332221007381
Fruit Compound May Have Potential to Prevent and Treat Parkinson’s Disease
Vaccines Are Pushing Pathogens to Evolve
Just as antibiotics breed resistance in bacteria, vaccines can incite changes that enable diseases to escape their control. Researchers are working to head off the evolution of new threats.
https://www.quantamagazine.org/vaccines-are-pushing-pathogens-to-evolve-20180510
Early Heparin Treatment Linked to Lower
COVID-19 Mortality
https://www.medscape.com/viewarticle/954853
The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses
https://www.medrxiv.org/content/10.1101/2021.05.03.21256520v1
SARS-CoV-2 proteins manipulate autophagy
https://www.news-medical.net/news/20210722/SARS-CoV-2-proteins-manipulate-autophagy.aspx
SARS-CoV-2 vaccination in the context of original antigenic sin
https://www.tandfonline.com/doi/full/10.1080/21645515.2021.1949953
Johnson & Johnson vaccine linked to rare cases of autoimmune disorder
The FDA issues a warning to Johnson & Johnson’s COVID vaccine label about a rare risk of Guillain-Barré syndrome.
https://www.cnet.com/health/johnson-johnson-vaccine-linked-to-rare-cases-of-autoimmune-disorder/
Immune interference – why even ‘updated’ vaccines could struggle to keep up with emerging coronavirus strains
Cannabinoid WIN 55,212-2 Inhibits Human Glioma Cell Growth by Triggering ROS-Mediated Signal Pathways
https://www.hindawi.com/journals/bmri/2021/6612592/
Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study
Researchers say evidence of hybridization between leukocytes and cancer indicates that this is a primary means of metastasis. Others disagree.
Gelangt so Coronavirus-Erbgut in unseres? RNA zu DNA – es geht wohl doch
https://www.focus.de/gesundheit/news/menschliche-zellen-rna-zu-dna-geht-doch_id_13394333.html
Establishing the prevalence of common tissue-specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection
https://academic.oup.com/cei/article/205/2/99/6431126
Andrographis Reverses Gemcitabine Resistance through Regulation of ERBB3 and Calcium Signaling Pathway in Pancreatic Ductal Adenocarcinoma
https://www.mdpi.com/2227-9059/11/1/119
Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, Angiogenesis Inhibition, and Autophagy Modulation
https://www.mdpi.com/1422-0067/23/24/16091
Curcumin suppresses lung cancer progression via circRUNX1 mediated miR-760/RAB3D axis
https://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.14773
A comprehensive overview of Artemisinin and its derivatives as anticancer agents
https://www.sciencedirect.com/science/article/abs/pii/S0223523422009023
Natural essential oils as a new therapeutic tool in colorectal cancer
https://link.springer.com/article/10.1186/s12935-022-02806-5
Baicalin – TRPV4 Promotes Metastasis in Melanoma by Regulating Cell Motility through Cytoskeletal Rearrangement
https://www.mdpi.com/1422-0067/23/23/15155
Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave
https://www.nature.com/articles/s41591-022-02138-x
Why biology’s ultimate comeback story could debunk a major Darwin theory of evolution
https://www.inverse.com/science/crabs-keep-evolving-but-why
How COVID Vaccines Cause Cancer
https://www.theepochtimes.com/health/how-covid-vaccines-cause-cancer_4952911.html
Population of “Cheating” Cancer Cells Identified by Researchers
Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
https://www.cell.com/cell/fulltext/S0092-8674(22)01531-8
Killing cancer softly: The resolution of cancer lies in tumor cells
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
https://www.nature.com/articles/s41586-022-05594-0
A liver drug reduces SARS-CoV-2 entry into cells
A widely used drug called UDCA reduces SARS-CoV-2 infection in human organoid structures, animals and human organs maintained outside the body. Individuals using UDCA for liver conditions are less likely to develop severe COVID-19 than are people who did not use it. UDCA treatment could help to protect people with suppressed immune systems and offer protectionagainst vaccine-resistant variants.
https://www.nature.com/articles/d41586-022-04149-7
Ancient Chinese medicine unlocks new possibilities for cancer treatment
The botanical drug YIV-906 (center) is developed from an 1800-year-old Chinese formula and relies on four naturally derived ingredients: licorice, skullcap, peony, and dates.
https://news.yale.edu/2020/03/13/ancient-chinese-medicine-unlocks-new-possibilities-cancer-treatment
The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I
https://www.biorxiv.org/content/10.1101/2020.05.24.111823v1
COVID – Naturarzneien aus Afrika – Artemesia annua & Ravensara aromatica (Lorbeergewächs)
https://www.pharmazeutische-zeitung.de/naturarzneien-aus-afrika-sollen-untersucht-werden-117384/
Brake on immune activity identified, raising new possibilities for anticancer therapy
https://www.sciencedaily.com/releases/2020/03/200325110902.htm
Compound with ‘exciting’ anticancer properties found in willow
https://www.zmescience.com/science/compound-with-exciting-anticancer-properties-found-in-willow/
Exercise’s Anticancer Mechanisms
A look at the molecular processes that may feed into the tumor-fighting effects of physical activity
https://www.the-scientist.com/infographics/infographic-exercises-anti-cancer-mechanisms-67323
Isoquercitrin – Exotic fruit juice shown to have anti-cancer effects against lung cancer – study
https://www.express.co.uk/life-style/health/1717500/kiwi-fruit-juice-anti-cancer-effects
Effect of Andrographolide and Its Analogs on Bacterial Infection
https://www.karger.com/Article/FullText/503410
Leukemia: Mushroom protein could be used in future treatments
A protein found in the edible mushroom known as “shaggy ink cap” might be able to kill a type of leukemia cell, new research suggests.
https://www.medicalnewstoday.com/articles/318910
Immunomodulatory effects of Andrographis paniculata extract in healthy adults
https://www.sciencedirect.com/science/article/pii/S0975947621001121
Lyme disease treatment: 2 herbal compounds may beat antibiotics
Lyme disease — transmitted via tick bite — affects thousands of people in the United States and around the world. Currently, doctors use antibiotics to treat it, but could plant-based remedies be more effective?
The researchers note that the ones with the highest antibacterial activity directed against B. burgdorferi were Ghanaian quinine and Japanese knotweed.