Articles and science papers (unsorted part 3.1)

Creatine in T Cell Antitumor Immunity and Cancer Immunotherapy

Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis

Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Glutamine deficiency promotes recurrence and metastasis in colorectal cancer through enhancing epithelial–mesenchymal transition

Dietary change starves cancer cells, overcoming treatment resistance

Laboratory research finds a low-protein diet can enhance standard treatment for colon cancer

These tiny bubbles are “warheads” for killing cancer

Researchers destroyed tumors in mice using low-frequency ultrasound and nanobubbles.

Interaction of Zn with Losartan. Activation of Intrinsic Apoptotic Signaling Pathway in Lung Cancer Cells and Effects on Alkaline and Acid Phosphatases

Severe COVID-19 is associated with molecular signatures of aging in the human brain

Combination of niclosamide and current therapies to overcome resistance for cancer: New frontiers for an old drug

NAD+ Helps Natural Killer Cells to Fight Cancer

Cancer fighting requires cellular energy.

Can NMN Supplements Cause Cancer?

Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination

Viagra lowers risk of Alzheimer’s disease by 69%, study finds

Dysregulated lipid synthesis by oncogenic IDH1 mutation is a targetable synthetic lethal vulnerability

Omicron BQ, XBB subvariants are a serious threat to boosters and knock out antibody treatments

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Potential Therapy for Metastatic Colon Cancer Identified in Preclinical Studies

Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer

Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study

Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis

Repurposing Disulfiram as an Antimicrobial Agent in Topical Infections

Colon cancer: Dying cancer cells give neighboring tumor cells instructions on how to survive

Researchers in Frankfurt, Germany, discover new mechanism of chemotherapy resistance in colon cancer

Potential Therapy for an Aggressive Type of Colon Cancer Identified in Preclinical Studies

Cancer treatments boosted by immune-cell hacking

Precision-controlled CAR-T-cell immunotherapies could be used to tackle a range of tumour types.

The Link Between Severe COVID and Exercise Is Even Stronger Than We Thought

Ceritinib – Repurposed Drug Can Target Cancer Cells’ Shield Against Immune System

The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein

Repurposing radiotherapy drugs could give immunotherapy a boost

Radical lupus treatment uses CAR T-cell therapy developed for cancer

Five people with the autoimmune condition lupus are now in remission after receiving a version of CAR-T therapy, which was originally developed for cancer

Losartan & Propranolol – Repurposing old drugs for new cancer treatments

Do fungi lurking inside cancers speed their growth?

Studies that scrutinized thousands of tumour samples provide the clearest link yet between cancer and fungi — but more research is needed.

Ovarian cancer mutational processes drive site-specific immune evasion

Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

AndrographisAndrographolide, an Herbal Medicine, Inhibits Interleukin-6 Expression and Suppresses Prostate Cancer Cell Growth

Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells

Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer

Aspirin and celecoxib revealed anticancer and immunomodulatory effects on colon cancer cells

Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

A substance in broccoli – Indole-3-carbinol in vitro antiviral activity against SARS-Cov-2 virus and in vivo toxicity

Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression

Population of “Cheating” Cancer Cells Identified by Researchers

Some cancer cells can “cheat” through escaping constraints imposed by lack of oxygen, allowing the cancer cells to continue to grow.

Gene therapy gel heals decades-old wounds in trial for blistering skin disease

Researchers find that a gel tested in patients with a life-threatening blistering skin disease helps wounds heal. The gel — the first topical gene therapy — awaits FDA approval.

Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy

Combining vitamin C with antibiotics destroys cancer stem cells

Diet, Microbiome, and Cancer Immunotherapy

Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)

Ursolic acid: a natural modulator of signaling networks in different cancers

New way of using DNA to kill cancer cells could pave the way for a cure, scientists say

  • University of Tokyo scientists may have paved a way to use DNA to cure cancer
  • Study author Professor Akimitsu Okamoto says their research is ‘good news’
  • It uses a hair clip shaped, cancer-killing DNA, which is injected into cancer cells

Glioblastoma-Specific Epigenetic Mechanism Identified that Scuppers Tumor Suppressor

Repurposing Opportunities in Oncology: Using ‘Old’ Drugs as ‘Novel’ Anti-cancer Agents

Essential Oils as Novel Anthelmintic Drug Candidates

Off-Patent Liver Disease Drug Could Stop COVID-19 and Protect Against Future Variants

  • Cambridge scientists have shown that a widely-used drug to treat liver disease can prevent SARS-CoV-2 infection or reduce COVID-19 severity
  • The drug has minimal side effects, is cheap, and should protect against future variants of SARS-CoV-2
  • Their unique study involved ‘mini-organs’, animal research, donated human organs, volunteers, and patients

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

The Antineoplastic Effect of Carboplatin Is Potentiated by Combination with Pitavastatin or Metformin in a Chemoresistant High-Grade Serous Carcinoma Cell Line

Repurposing Disulfiram as an Antimicrobial Agent in Topical Infections

Brand-new treatment stops tumor cells from ‘hiding’ and is being tested in the US

Population of “Cheating” Cancer Cells Identified by Researchers

Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness

Ceritinib – Repurposed Drug Can Target Cancer Cells’ Shield Against Immune System

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells

Pentoxifylline induces caspase-dependent apoptosis in colorectal cancer cells

Celecoxib promotes the efficacy of STING-targeted therapy by increasing antitumor CD8+ T-cell functions via modulating glucose metabolism of CD11b+Ly6G+ cells

Metformin – An Old Diabetes Drug May Protect You Against Long COVID

Study discovers triple immunotherapy combination as possible treatment for pancreatic cancer

Targeting T cells and myeloid cells together improved anti-tumor response and survival in preclinical models

How COVID Vaccines Cause Cancer

Propolis: The Role of Propolis in Cancer

Red Ginseng Extract and γ-Aminobutyric Acid Synergistically Enhance Immunity Against Cancer Cells and Antitumor Metastasis Activity

Natural Killer Cell-Based Cancer Immunotherapy

Can exercise increase natural killer cell infiltration of the prostate?

Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution

The Latest Approach of Immunotherapy with Endosomal TLR Agonists Improving NK Cell Function

Potential of Compounds Originating from the Nature to Act in Hepatocellular Carcinoma Therapy by Targeting the Tumor Immunosuppressive Microenvironment

Tumor Microenvironment and Metabolism: Role of the Mitochondrial Melatonergic Pathway in Determining Intercellular Interactions in a New Dynamic Homeostasis

An omega-3 that’s poison for tumors

Seasonal coronavirus–specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19

Chinese whistleblower claims first COVID outbreak was INTENTIONAL and happened in October 2019 at Military World Games in Wuhan – two months before China notified the world about virus

  • Defector Wei Jingsheng said virus may have first spread at military tournament
  • Reports emerged in October 2019 athletes at event fell ill with mystery sickness
  • Mr Jingsheng alleged China deliberately spread virus during Military Games 
  • He claims he took his concerns to senior figures in the US gov but was ignored

Deutsche Ärztin heilt erstmals Long-Covid: „Es ist wie ein Riesen-Wunder“

Manathakkali holds hope for liver cancer patients

An RGCB team gets international patents for discovering compound with anti-cancer properties in its leaves

Ivermectin as a Broad-Spectrum Host-Directed Antiviral

Cancer drug repurposed to treat malaria shown to be nearly 100% effective

Researchers discover how cholesterol feeds cancer metastasis

Page copies of the report, unsorted:

Heparin’s COVID-19 Benefit Greatest in Moderately Ill Patients

Ivermectin – Israeli scientist says COVID-19 could be treated for under $1/day

Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19

New drug combo shows early potential for treating pancreatic cancer

Researchers find three immunotherapy drugs given together can eliminate pancreatic tumors in mice.

Exercise Improves Health Through Changes to DNA

A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status

Ivermectin and Doxycycline might present better clinical outcomes against COVID-19.•

Ivermectin might present as a prophylactic approach against COVID-19.•

Vitamin-D, Vitamin-C, Zinc, and cannabidiol combination boost immunity.

Fruit Compound May Have Potential to Prevent and Treat Parkinson’s Disease

Vaccines Are Pushing Pathogens to Evolve

Just as antibiotics breed resistance in bacteria, vaccines can incite changes that enable diseases to escape their control. Researchers are working to head off the evolution of new threats.

Early Heparin Treatment Linked to Lower
COVID-19 Mortality

The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses

SARS-CoV-2 proteins manipulate autophagy

SARS-CoV-2 vaccination in the context of original antigenic sin

Johnson & Johnson vaccine linked to rare cases of autoimmune disorder

The FDA issues a warning to Johnson & Johnson’s COVID vaccine label about a rare risk of Guillain-Barré syndrome.

Immune interference – why even ‘updated’ vaccines could struggle to keep up with emerging coronavirus strains

Cannabinoid WIN 55,212-2 Inhibits Human Glioma Cell Growth by Triggering ROS-Mediated Signal Pathways

Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study

Researchers say evidence of hybridization between leukocytes and cancer indicates that this is a primary means of metastasis. Others disagree.

Gelangt so Coronavirus-Erbgut in unseres? RNA zu DNA – es geht wohl doch

Establishing the prevalence of common tissue-specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection

Andrographis Reverses Gemcitabine Resistance through Regulation of ERBB3 and Calcium Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Anticancer Effects of Fucoxanthin through Cell Cycle Arrest, Apoptosis Induction, Angiogenesis Inhibition, and Autophagy Modulation

Curcumin suppresses lung cancer progression via circRUNX1 mediated miR-760/RAB3D axis

A comprehensive overview of Artemisinin and its derivatives as anticancer agents

Natural essential oils as a new therapeutic tool in colorectal cancer

Baicalin – TRPV4 Promotes Metastasis in Melanoma by Regulating Cell Motility through Cytoskeletal Rearrangement

Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave

Why biology’s ultimate comeback story could debunk a major Darwin theory of evolution

How COVID Vaccines Cause Cancer

Population of “Cheating” Cancer Cells Identified by Researchers

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Killing cancer softly: The resolution of cancer lies in tumor cells

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

A liver drug reduces SARS-CoV-2 entry into cells

A widely used drug called UDCA reduces SARS-CoV-2 infection in human organoid structures, animals and human organs maintained outside the body. Individuals using UDCA for liver conditions are less likely to develop severe COVID-19 than are people who did not use it. UDCA treatment could help to protect people with suppressed immune systems and offer protectionagainst vaccine-resistant variants.

Ancient Chinese medicine unlocks new possibilities for cancer treatment

The botanical drug YIV-906 (center) is developed from an 1800-year-old Chinese formula and relies on four naturally derived ingredients: licorice, skullcap, peony, and dates.

The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I

COVID – Naturarzneien aus Afrika – Artemesia annua & Ravensara aromatica (Lorbeergewächs)

Brake on immune activity identified, raising new possibilities for anticancer therapy

Compound with ‘exciting’ anticancer properties found in willow

Exercise’s Anticancer Mechanisms

A look at the molecular processes that may feed into the tumor-fighting effects of physical activity

Isoquercitrin – Exotic fruit juice shown to have anti-cancer effects against lung cancer – study

Effect of Andrographolide and Its Analogs on Bacterial Infection

Leukemia: Mushroom protein could be used in future treatments

A protein found in the edible mushroom known as “shaggy ink cap” might be able to kill a type of leukemia cell, new research suggests.

Immunomodulatory effects of Andrographis paniculata extract in healthy adults

Lyme disease treatment: 2 herbal compounds may beat antibiotics

Lyme disease — transmitted via tick bite — affects thousands of people in the United States and around the world. Currently, doctors use antibiotics to treat it, but could plant-based remedies be more effective?

The researchers note that the ones with the highest antibacterial activity directed against B. burgdorferi were Ghanaian quinine and Japanese knotweed.