Articles and science papers (unsorted part 2.2)

A healthy microbiome builds a strong immune system that could help defeat

Diabetes drug metformin may help treat common heart rhythm disease

Resveratrol – Natural Plant Compound in Grapes Protects Brain Health, Research Reveals

https://www.theepochtimes.com/natural-plant-compound-in-grapes-protects-brain-health-research-reveals_4677975.html

Scientists find a new cause of COVID-19 death

Common diabetes drug may cause dangerous infection disease

Aspirin may improve survival for bladder and breast cancers

Eating peanut too much may increase risk of cancer spread

This drug for inflammation may increase your diabetes risk within days

Common nutritional supplement could help boost cancer therapy

Unhealthy gut boosts development of breast cancer, shows study

Common painkiller ibuprofen may strongly influence your liver

Grape seed extract may help increase lifespan, reduce cancer risk

Loperamide – drug for diarrhea may help treat deadly brain cancer

Obesity-Induced Liver Cancer Triggered by Leaky Membranes

Why diabetes strongly increases risk of severe COVID-19

‘Masked’ cancer drug stealthily trains immune system to kill tumors while sparing healthy tissues, reducing treatment side effects

https://news.yahoo.com/masked-cancer-drug-stealthily-trains-121437574.html

Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells

https://www.sciencedirect.com/science/article/pii/S1567576922003496

A Potential New Treatment for High-Grade Glioma: A Study Assessing Repurposed Drug Combinations against Patient-Derived High-Grade Glioma Cells

irinotecan, pitavastatin, disulfiram, copper gluconate, captopril, celecoxib, itraconazole and ticlopidine

https://www.mdpi.com/2072-6694/14/11/2602

HIV drug shows promise against metastatic cancer

HIV drug shows promise against metastatic cancer

“Keto” Molecule May Be Useful in Preventing and Treating Colorectal Cancer

https://www.pennmedicine.org/news/news-releases/2022/april/keto-molecule-may-be-useful-in-preventing-and-treating-colorectal-cancer-penn-study-suggests

How diet and the microbiome affect colorectal cancer

UC research identifies microbial species elevated in young patients

https://www.uc.edu/news/articles/2022/06/uc-studies-microbiomes-effect-on-young-colorectal-cancer.html

Current understanding of phytochemicals from Chinese herbal medicines for ferroptosis-mediated cancer prevention and treatment

https://www.sciencedirect.com/science/article/pii/S2667142522000604

Mouse Study Reveals How to Help Speed Up The Liver’s Self-Regeneration Process

https://www.sciencealert.com/mouse-study-reveals-how-to-help-speed-up-the-livers-self-regeneration-process

Could COVID-19 infections trigger a relapse of mycosis fungoides or other cutaneous T-cell lymphomas?

https://www.news-medical.net/news/20221017/Could-COVID-19-infections-trigger-a-relapse-of-mycosis-fungoides-or-other-cutaneous-T-cell-lymphomas.aspx

A Natural Compound That Can Help Cure Leukemia

A Natural Compound That Can Help Cure Leukemia

Fighting superbugs: Compound related to antimalarial drug shows promise

https://www.medicalnewstoday.com/articles/knee-compression-sleeves-2

B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12

https://www.nature.com/articles/s41598-022-16152-z

Bone marrow–confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia

https://www.jci.org/articles/view/152673

Creating MHC-restricted neoantigens with covalent inhibitors that can be targeted by immune therapy

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-1074/709728/Creating-MHC-restricted-neoantigens-with-covalent

Do fungi lurking inside cancers speed their growth?

https://www.nature.com/articles/d41586-022-03074-z

The antimicrobial potential of cannabidiol

https://www.nature.com/articles/s42003-020-01530-y

Hirschhausen und Long Covid – Die Pandemie der Unbehandelten

https://www.daserste.de/information/ratgeber-service/hirschhausens-check-up/videos/hirschhausen-und-long-covid-video-102.html

Study revises understanding of cancer metabolism

Study revises understanding of cancer metabolism

Albendazole exerts an anti-hepatocellular carcinoma effect through a WWOX-dependent pathway

https://www.sciencedirect.com/science/article/abs/pii/S002432052200786X

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

https://www.mdpi.com/2072-6694/14/14/3368

Combination of niclosamide and current therapies to overcome resistance for cancer: New frontiers for an old drug

https://www.sciencedirect.com/science/article/pii/S0753332222011787

Reactivity and binding mode of disulfiram, its metabolites, and derivatives in SARS-CoV-2 PLpro: insights from computational chemistry studies

https://link.springer.com/article/10.1007/s00894-022-05341-2

How blood cancer cells put the immune system’s ‘Natural Killer’ cells to sleep

https://medicalxpress.com/news/2022-04-blood-cancer-cells-immune-natural.html

Humans are 8% virus – how the ancient viral DNA in your genome plays a role in human disease and development

https://theconversation.com/humans-are-8-virus-how-the-ancient-viral-dna-in-your-genome-plays-a-role-in-human-disease-and-development-192322

COVID-19 Virus Infects Neurons, Induces Inflammation in the Brains of Rhesus Macaques

https://www.ucdavis.edu/health/news/covid-19-virus-infects-neurons-induces-inflammation-brains-rhesus-macaques

Addiction drug shows promise lifting long COVID brain fog, fatigue

https://www.ksl.com/article/50497440/addiction-drug-shows-promise-lifting-long-covid-brain-fog-fatigue

Woran Gras auf Rezept noch immer scheitert

https://www.zeit.de/gesundheit/2022-10/medizinisches-cannabis-rezept-kosten

Magnesium is essential for the immune system, including in the fight against cancer

https://www.unibas.ch/en/News-Events/News/Uni-Research/Magnesium-is-essential-for-the-immune-system–including-in-the-fight-against-cancer.html

Corona-Pille – Forschung mit Hindernissen

Die Clofoctol Story

Zwei Jahre lang begleitete die Doku das Taskforce-Team des Pasteur-Instituts von Lille (IPL) hautnah bei seinen Forschungsarbeiten für ein Medikament gegen Covid-19. Die Wissenschaftler des IPL wissen, dass ihre Stunde gekommen ist: Ein neues Medikament könnte die Menschheit vor einer verheerenden Pandemie retten. Aber wo soll man ansetzen?

März, 2020: Frankreich geht in den Lockdown. Während fast alles stillsteht, steckt sich ein Team von Wissenschaftlerinnen und Wissenschaftlern ein ehrgeiziges Ziel: die Entwicklung eines Medikaments gegen Covid-19. Schauplatz ist das Pasteur-Institut von Lille (IPL). Das Taskforce-Team sucht fieberhaft nach einem Wirkstoff gegen die Krankheit. Recht schnell entscheidet man sich für das Umfunktionieren einer alten Substanz.
Tag und Nacht screenen die Wissenschaftler Tausende von Ausgangssubstanzen, die gegen Sars-CoV-2 wirken könnten. Tatsächlich finden sie eine Hit-Substanz, deren Name zunächst geheim gehalten wird. Film ansehen:

https://www.arte.tv/de/videos/104798-000-A/corona-pille-forschung-mit-hindernissen/

https://journals.plos.org/Plospathogens/article?id=10.1371/journal.ppat.1010498

https://www.medicalnewstoday.com/articles/covid-19-repurposed-antibiotic-shows-promise-in-mouse-model

Clofoctol fight cancer too

A new horizon for the old antibacterial drug clofoctol

https://www.sciencedirect.com/science/article/abs/pii/S1359644621000702

The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13

https://www.jci.org/articles/view/124979

Overcoming Drug Resistance in Advanced Prostate Cancer by Drug Repurposing

https://www.mdpi.com/2076-3271/10/1/15

Scientists Track Eels to Their Ocean Breeding Grounds in World-First

https://www.sciencealert.com/scientists-track-eels-to-their-ocean-breeding-grounds-in-world-first

6-gingerol upregulated CD8+ T cells function in mice model of colorectal cancer

https://aacrjournals.org/cancerres/article/82/12_Supplement/4218/700093

Long Covid – Die Pandemie der Unbehandelten

https://www.daserste.de/information/ratgeber-service/hirschhausens-check-up/videos/hirschhausen-und-long-covid-video-102.html

Do fungi lurking inside cancers speed their growth?

Studies that scrutinized thousands of tumour samples provide the clearest link yet between cancer and fungi

https://www.nature.com/articles/d41586-022-03074-z

A healthy microbiome builds a strong immune system that could help defeat

New data is out on COVID vaccine injury claims. What’s to make of it?

https://www.reuters.com/legal/litigation/new-data-is-out-covid-vaccine-injury-claims-whats-make-it-2022-10-12/

Can diet change the course of cancer?

https://cen.acs.org/food/diet-change-course-cancer/100/i33

Old drugs offer new ways of treating bowel cancer

https://www.sciencedaily.com/releases/2022/10/221011183859.htm

Response to BRAF targeted therapy is enhanced by co-targeting VEGFRs or WNT/β-Catenin signaling in BRAF-mutant colorectal cancer models

https://aacrjournals.org/mct/article/doi/10.1158/1535-7163.MCT-21-0941/709616/Response-to-BRAF-targeted-therapy-is-enhanced-by

Repurposing of Benzimidazole Anthelmintic Drugs as Cancer Therapeutics

https://www.mdpi.com/2072-6694/14/19/4601/htm

Nine dollar per tablet drug used to treat HIV patients could help reverse memory loss in older age, study finds

https://www.dailymail.co.uk/health/article-10861649/9-tablet-drug-used-treat-HIV-patients-help-reverse-memory-loss.html

Reviewing immunological breast cancer targets

https://www.news-medical.net/whitepaper/20220530/Reviewing-immunological-breast-cancer-targets.aspx

The Paired Perils of Breast Cancer and Diabetes

https://today.ucsd.edu/story/the-paired-perils-of-breast-cancer-and-diabetes

Evolution May Be Happening Up to 4 Times Faster Than We Thought, Massive Study Finds

https://www.sciencealert.com/evolution-may-be-happening-up-to-four-times-faster-than-we-thought

Wie kam Corona in die Welt? Ein bislang wenig beachteter Recherchebericht stärkt die These, ein Laborunfall könnte die Sars-CoV-2-Pandemie ausgelöst haben.

https://www.focus.de/gesundheit/news/war-corona-doch-ein-laborunfall-neue-daten-bestaerken-virusverdacht_id_102722120.html

A vaccine targeting resistant tumours by dual T cell plus NK cell attack

https://www.nature.com/articles/s41586-022-04772-4

Novel cancer vaccines by Dana-Farber and Stanford look beyond T cells to better fight tumors

https://www.fiercebiotech.com/research/novel-cancer-vaccines-dana-farber-and-stanford-look-beyond-t-cells-better-fight-tumors

Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag

https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1

Man caught with £10,000 cannabis haul spared jail after cancer patients defend ‘life-saving treatment’

https://www.independent.co.uk/news/uk/home-news/medicinal-cannabis-spared-jail-cancer-patients-b2083747.html

Der “grünen Lunge der Erde” droht die Zerstörung

Brasiliens Amazonas-Regenwald verfügt nicht nur über eine gigantische Artenvielfalt und “fliegende Flüsse”. Er ist auch essenziell in der Bekämpfung der Klimakrise. Das “Klima-Update” widmet sich in dieser Folge der Lage im Amazonas-Becken.

https://www.n-tv.de/mediathek/videos/wissen/Der-gruenen-Lunge-der-Erde-droht-die-Zerstoerung-article23345820.html

New DNA Repair Mechanism Holds Promise for Precision Cancer Therapies

This study shows the major cause of Parkinson’s disease

Scientists from the University of Copenhagen found that the most common form of the disease, encompassing 90% to 95% of all Parkinson’s Disease cases known as sporadic PD, is caused by a blockage of a pathway that regulates the nerve cell’s powerhouse, the mitochondria.

First Patient Dosed With Experimental Cancer-Killing Virus in New Trial

https://gizmodo.com/vaxinia-cancer-killing-virus-clinical-trial-1848943666

We Just Got Closer to The Secret of How Turtles Navigate in The Open Ocean

https://www.sciencealert.com/turtles-have-an-uncanny-knack-for-pinpointing-islands-in-the-ocean-but-it-s-mostly-luck

Researchers find natural mechanism to sensitize cancer to immunotherapy

https://labblog.uofmhealth.org/lab-notes/researchers-find-natural-mechanism-to-sensitize-cancer-to-immunotherapy

Study reveals how to activate the immune system’s natural killer cells to protect against cancer and other diseases

Losartan

https://www.sciencedaily.com/releases/2022/03/220316145739.htm

Extracellular matrix proteins regulate NK cell function in peripheral tissues

https://www.science.org/doi/10.1126/sciadv.abk3327

Solid Tumors Use T Cells as a Shield Against Immune Attack

https://www.technologynetworks.com/cancer-research/news/solid-tumors-use-t-cells-as-a-shield-against-immune-attack-361593

Spätfolgen von Long Covid: Genesungszeit beträgt bis zu zwei Jahre

https://www.focus.de/gesundheit/coronavirus/long-covid-kein-ende-in-sicht_id_98031844.html

Study Shows Link Between Consumption of Dairy and Cancer

https://www.medscape.co.uk/viewarticle/study-shows-link-between-consumption-dairy-and-cancer-2022a10016co

Beating the odds: Cancer survivor to run his 600th marathon

https://eu.usatoday.com/story/news/2022/05/15/cancer-survivor-run-his-600th-marathon-later-month/9750373002/

Fundamental immune–oncogenicity trade-offs define driver mutation fitness

https://www.nature.com/articles/s41586-022-04696-z

Scientists shed new light on how early stage breast cancer spreads to other organs

https://www.cnbc.com/2022/04/26/scientists-shed-new-light-on-how-early-stage-breast-cancer-spreads-to-other-organs.html

Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes

https://academic.oup.com/mbe/article/39/5/msac084/6570859

Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01243-w

The Origin of Life on Earth: A Paradigm Shift

The Origin of Life on Earth: A Paradigm Shift

Immune cells regulate body weight

https://medicalxpress.com/news/2022-03-immune-cells-body-weight.html

Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives

https://www.sciencedirect.com/science/article/pii/S1043661822000834

Methionine Restriction: Ready for Prime Time in the Cancer Clinic?

https://ar.iiarjournals.org/content/42/2/641.abstract

Methionine Dependence of Cancer

https://www.mdpi.com/2218-273X/10/4/568

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

https://medicalxpress.com/news/2022-05-quiescent-cancer-cells-resist-tcell.html

COVID-19 mortality among elderly may be due to genetically predetermined limit on the immune system

https://www.news-medical.net/news/20220509/COVID-19-mortality-among-elderly-may-be-due-to-genetically-predetermined-limit-on-the-immune-system.aspx

Epstein-Barr Virus a Likely Leading Cause of Multiple Sclerosis

https://www.medscape.com/viewarticle/966604

Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer

https://www.nature.com/articles/s41419-022-04823-8

Octopus – New Analysis Shows Chephalopod Genomes Are Even Weirder Than You’d Expect

https://www.sciencealert.com/modern-squid-and-octopus-genomes-look-like-they-were-put-into-a-blender-compared-to-their-ancestors

Effects of caloric restriction on the gut microbiome are linked with immune senescence

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01249-4

Immune Cell Profiles Reveal Cancer’s Leading Indicators

Dynamic cancer transcriptome exposes new therapeutic targets

Sequencing RNA as well as DNA is giving researchers an extra dimension of information, and pointing oncologists towards potential avenues for treatment.

https://www.nature.com/articles/d42473-021-00571-z

How to Tell whether a Cancer Is Caused by Plain Bad Luck

A new study offers a possible answer to the question “Why me?”

https://www.scientificamerican.com/article/how-to-tell-whether-a-cancer-is-caused-by-plain-bad-luck/

As The Oceans Warm, Marine Life Faces Extinction Levels That Rival The Dinosaurs’ End

https://www.sciencealert.com/we-re-pummeling-towards-a-dinosaur-ending-scale-mass-extinction-of-marine-life

Trove of tumour genomes offers clues to cancer origins

Largest-ever study uncovers patterns of mutations that might pinpoint cancer’s causes.

https://www.nature.com/articles/d41586-022-01095-2

Statins Decrease Programmed Death-Ligand 1 (PD-L1) by Inhibiting AKT and β-Catenin Signaling

https://www.mdpi.com/2073-4409/10/9/2488/htm

Nutrition, longevity and disease: From molecular mechanisms to interventions

https://www.cell.com/cell/fulltext/S0092-8674(22)00398-1

Forscher entschlüsseln fatalen Metastasen-Mechanismus bei Brustkrebs

https://www.focus.de/gesundheit/ratgeber/krebs/forschung/protein-mix-programmiert-fresszellen-um-forscher-entdecken-fatalen-metastasen-mechanismus-bei-brustkrebs_id_89798667.html

CBD from cannabis may inhibit COVID-19, research finds

Study illuminates why cowpea mosaic virus is exceptionally effective against cancer

https://www.news-medical.net/news/20220427/Study-illuminates-why-cowpea-mosaic-virus-is-exceptionally-effective-against-cancer.aspx

Zeitenwende in Thailands Drogenpolitik

https://www.nzz.ch/international/cannabis-in-bangkok-spriessen-die-geschaefte-aus-dem-boden-ld.1699351

Scientists Use Sound to Destroy Half of Liver Tumors – and Boosted Immune Systems Cleared Away the Rest

A Clearer Picture of Multiple Sclerosis

Five types of bacteria linked to aggressive prostate cancer

https://medicalxpress.com/news/2022-04-bacteria-linked-aggressive-prostate-cancer.html

Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

https://www.sciencedirect.com/science/article/pii/S0944711320301082

Thymoquinone – Traditional Herbal Medicine Kills Pancreatic Cancer Cells, Researchers Report

https://www.sciencedaily.com/releases/2008/05/080519092215.htm

Natural ‘cures’ for pancreatic cancer

https://guardian.ng/features/health/natural-cures-for-pancreatic-cancer/

Waning Immunity after the BNT162b2 Vaccine in Israel

https://www.nejm.org/doi/full/10.1056/NEJMoa2114228

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade

https://www.science.org/doi/abs/10.1126/scitranslmed.aat5025

Repurposing infectious disease vaccines for intratumoral immunotherapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057427/

A Strange Genetic Link Between Humans And Sea Anemones Was Just Confirmed

https://www.sciencealert.com/a-gene-linked-to-hearing-in-humans-helps-anemones-feel-the-world-around-them

Treating triple-negative breast cancer: Cardamom compound shows promise

https://www.medicalnewstoday.com/articles/treating-triple-negative-breast-cancer-cardamom-compound-shows-promise

Pancreatic cancer treated in mice by loading tumour cells with tetanus

A new type of therapy aims to exploit immunity gained from childhood tetanus vaccinations to make the immune system attack hard-to-treat pancreatic cancer

https://www.newscientist.com/article/2313208-pancreatic-cancer-treated-in-mice-by-loading-tumour-cells-with-tetanus/

A million times faster: DNA nanotechnology could speed up pharmaceutical development while minimizing costs

https://phys.org/news/2022-04-million-faster-dna-nanotechnology-pharmaceutical.html

‘Impossible’ chemistry may reveal origins of life on Earth

https://www.nationalgeographic.com/science/article/impossible-chemistry-may-reveal-origins-of-life-on-earth

Black cardamom (Amomum subulatum Roxb.) fruit extracts exhibit apoptotic activity against lung cancer cells

https://www.sciencedirect.com/science/article/abs/pii/S0378874121011831

Effects of Cardamonin on PD-1/PD-L1 Checkpoint in Triple-Negative Breast Cancer

https://www.eventscribe.net/2022/EB2022/fsPopup.asp?PresentationID=1027346&query=Mendonca&mode=presinfo&fbclid=IwAR3SLCw-zv-qAOCuCN1R4JJMZ4HoqQzs2G3UbqvVj89YVQaH8nBiuxukS7w

Coronavirus (SARS-CoV-2) Deactivation via Spike Glycoprotein Shielding by Old Drugs: Molecular Docking Approach

Today the disease of COVID-19 comprises the most serious problem against human health worldwide with a high rate of virulence and mortality. The disease is caused by the SARS-CoV-2 virus from the beta coronavirus family. The virus makes use of its surface glycoprotein named S protein or spike to enter the human cells. The virus is attached to its receptor of angiotensin-converting enzyme 2 on the cell surface via its receptor-binding domain and fused after cleavage at S2′ site that is carried out by surface protease. Vaccines or drugs interfering with S protein binding or blocking the cleavage sites of S protein could be considered as a treat to get rid of the infection. In the current work and through molecular docking and molecular dynamics experiments, 14 drugs were selected based on their molecular weights among 100 drugs to study their shielding potency toward S protein binding sites. The obtained results indicate that fidaxomicin, niclosamide, and flubendazole bind specifically to the S2′ cleavage site; while ivermectin, rapamycin, heparin, azithromycin, clarithromycin, and erythromycin bind both receptor-binding domain and S2′ and can prevent virus attachment to its receptor and may be useful as a prophylactic candidate for COVID-19 management after clinical approval.

https://jep.usb.ac.ir/article_6658.html

Coronavirus (SARS-CoV-2) Deactivation via Spike Glycoprotein Shielding by Old Drugs: Molecular Docking Approach

‘We need to rethink how we are studying cancer metabolism’

‘We need to rethink how we are studying cancer metabolism’

Niacin (or vitamin B3)Could a simple dietary supplement treat Alzheimer’s?

Alzheimer’s disease has proven to be one of the most difficult neurodegenerative diseases to fight, with Big Pharmas and biotechs alike laboring to find a therapy that sticks. But researchers from Indiana University (IU) School of Medicine say a simple dietary supplement, niacin (or vitamin B3), shows promise.

https://www.fiercebiotech.com/biotech/new-research-suggests-simple-dietary-supplement-could-treat-alzheimers

Tetanus vaccination – Novel therapeutic strategy shows promise against pancreatic cancer

https://www.sciencedaily.com/releases/2022/03/220323151658.htm

How Sugar Promotes Inflammation

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers

https://www.mdpi.com/1422-0067/23/1/519

Oral Drug Prevents Death From COVID-19 in Old Mice by Reversing Immune Aging

Scientists find a universal antibody therapy for all COVID-19 variants

Antabuse May Help Revive Vision in People With Progressive Blinding Disorders

LosartanStudy reveals how to activate natural killer cells to protect against cancer and other diseases

https://www.massgeneral.org/news/press-release/study-reveals-how-to-activate-natural-killer-cells-to-protect-against-cancer

https://www.pnas.org/cgi/doi/10.1073/pnas.1819889116

Antifibrotic therapy to normalize the tumor microenvironment

https://link.springer.com/article/10.1186/s12967-020-02376-y

Understanding the immune landscape and tumor microenvironment of pancreatic cancer to improve immunotherapy

https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23179

Endothelin Inhibition Potentiates Cancer Immunotherapy Revealing Mechanical Biomarkers Predictive of Response

https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202000289

Tackling Cancer by Stabilizing Chromosomes

https://www.technologynetworks.com/cancer-research/news/tackling-cancer-by-stabilizing-chromosomes-359714

New Insight Into Possible Origins of Life: For the First Time Researchers Create an RNA Molecule That Replicates

New Insight Into Possible Origins of Life: For the First Time Researchers Create an RNA Molecule That Replicates

Exercise May Treat Long COVID-Induced Diabetes and Depression

In Mice, a Potential New Treatment Eradicates Ovarian And Colorectal Cancer in Days

High dose of interleukin-2 (IL2) – a natural compound that enlists white blood cells in the fight against cancer.

https://www.sciencealert.com/new-drug-factory-beads-can-wipe-out-some-cancers-in-mice

Pfizer’s COVID-19 Vaccine Goes Into Liver Cells And Is Converted To DNA: Study

https://www.zerohedge.com/covid-19/pfizers-covid-19-vaccine-goes-liver-cells-and-converted-dna-study

Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line

https://www.mdpi.com/1467-3045/44/3/73/htm

Natural ‘cures’ for pancreatic cancer

https://guardian.ng/features/health/natural-cures-for-pancreatic-cancer

Fenbendazole Suppresses Growth and Induces Apoptosis of Actively Growing H4IIE Hepatocellular Carcinoma Cells via p21-Mediated Cell-Cycle Arrest

Fenbendazole Suppresses Growth and Induces Apoptosis of Actively Growing H4IIE Hepatocellular Carcinoma Cells via p21-Mediated Cell-Cycle Arrest

Bendimidazole anthelmintics (BAs) have gained interest for their anticancer activity. The anticancer
activity is mediated via multiple intracellular changes, which are not consistent under different conditions
even in the same cells. We investigated the anticancer activity of fenbendazole (FZ, one of BAs) under two
different growth conditions. The growth rate of H4IIE cells was dose-dependently decreased by FZ only in
actively growing cells but not in fully confluent quiescent cells. Apoptosis-associated changes were also in-
duced by FZ in actively growing cells. Markers of autophagy were not changed by FZ. The number of cells
was markedly increased in sub-G1 phase but decreased in S- and G2/M phases by FZ. FZ up-regulated
p21 (an inhibitor of cyclin-CDK) but suppressed the expression of cell cycle-promoting proteins (cyclin D1
and cyclin B1). FZ did not affect integrin αV or n-cadherin expression as well as cell migration. Glycolytic
changes (glucose consumption and lactate production) and the generation of reactive oxygen species (ROS)
were not affected by FZ. Although the activity of mitogen-activated protein kinases (MAPKs) was altered by
FZ, the inhibition of MAPKs did not affect the pro-apoptotic activity of FZ. Taken together, FZ selectively
suppressed the growth of cells via p21-mediated cell cycle arrest at G1/S and G2/M, and resulted in apoptosis
only in actively growing cells but not in quiescent cells. Glucose metabolism, ROS generation, and MAPKs
are unlikely targets of FZ at least in H4IIE rat hepatocellular carcinoma cells used in this study.