Articles and science papers (unsorted part 2.3)

How the Ancient Viral DNA in Our Genome Affects Disease and Development

Human endogenous retroviruses make up 8 percent of the human genome. Researchers are studying how active they are

https://www.scientificamerican.com/article/how-the-ancient-viral-dna-in-our-genome-affects-disease-and-development/

Gene therapy: How can poorer countries access the most expensive drugs in the world?

https://www.weforum.org/agenda/2022/10/gene-therapies-hiv-cancer-uganda/

Study reports blocking key enzyme boosts anti-cancer T-cell responses and resistance to immunosuppression

https://www.sciencedaily.com/releases/2022/08/220829112853.htm

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses

https://www.frontiersin.org/articles/10.3389/fimmu.2022.987298/full

The Effect of Glucose on Rapid Cancer Cell Proliferation & Waste

https://journals.lww.com/oncology-times/Fulltext/2022/10200/The_Effect_of_Glucose_on_Rapid_Cancer_Cell.13.aspx

An Examination of the Anti-Cancer Properties of Plant Cannabinoids in Preclinical Models of Mesothelioma

https://www.mdpi.com/2072-6694/14/15/3813

Doctors may have found a secret weapon to fight cancer: Viagra

Doctors may have found a secret weapon to fight cancer: Viagra

Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts

https://www.sciencedirect.com/science/article/pii/S2666379122000416

Nivolumab Plus Ipilimumab Vs. Chemotherapy: Survival Outcome

Blue-Green Algae Could Help Treat Cancer And Alzheimer’s Disease

https://www.discovermagazine.com/health/blue-green-algae-could-help-treat-cancer-and-alzheimers-disease

A dog parasite could help fight incurable cancers—what our immunotherapy research revealed

https://medicalxpress.com/news/2022-10-dog-parasite-incurable-cancerswhat-immunotherapy.html

Cholesterol-lowering drug tested for effect on prostate cancer tumors

https://hollingscancercenter.musc.edu/news/archive/2022/08/05/cholesterol-lowering-drug-tested-for-effect-on-prostate-cancer-tumors

Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin

We formerly reported that the combination of dichloroacetate, omeprazole, and tamoxifen blocked cancer progression by reducing lactic acid production and inducing superoxide production. Recently, ivermectin, a well-known anti-parasite drug, was reported to share the same mechanisms with them and have anti-tumor activity. Here, we present three patients in whom the combination of dichloroacetate, omeprazole (plus tamoxifen), and ivermectin dramatically relieved the symptoms accompanying cancer and sarcoma progression.

https://www.cureus.com/articles/83821-synergistic-anti-tumor-effect-of-dichloroacetate-and-ivermectin

Anticancer, antioxidant, antiviral and antimicrobial activities of Kei Apple (Dovyalis caffra) fruit

https://www.nature.com/articles/s41598-022-09993-1

Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells

https://www.kjpp.net/journal/view.html?doi=10.4196/kjpp.2022.26.5.377

Fenbendazole induces cell cycle arrest in colorectal cancer cells and patient-derived colon cancer organoids

https://aacrjournals.org/cancerres/article/82/12_Supplement/2313/701049

Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer

https://www.sciencedirect.com/science/article/abs/pii/S0024320522002363

Cyclodextrin Dispersion of Mebendazole and Flubendazole Improves In Vitro Antiproliferative Activity

https://www.mdpi.com/2227-9717/9/12/2185

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

https://www.mdpi.com/2072-6694/14/14/3368

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers

https://www.mdpi.com/1422-0067/23/1/519

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

https://www.mdpi.com/2072-6694/12/2/287

Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684115/

IVC ProtocolVitamin-C

https://riordanclinic.org/research-study/vitamin-c-research-ivc-protocol/

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0876-0

Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells

https://www.researchgate.net/publication/260343692_Effects_of_fenbendazole_and_vitamin_E_succinate_on_the_growth_and_survival_of_prostate_cancer_cells

Anti-inflammatory ω-3 endocannabinoid epoxides

https://www.pnas.org/doi/full/10.1073/pnas.1610325114

Scientists discover slug that can decapitate itself, grow new body

The bizarre discovery could pave the way for advances in regenerative medicine for humans.

https://www.freethink.com/science/sea-slug-regenerative-medicine

Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15661

The NALCN channel regulates metastasis and nonmalignant cell dissemination

https://www.nature.com/articles/s41588-022-01182-0

The Race to Make a Vaccine for Breast Cancer

https://time.com/6220114/breast-cancer-vaccine-development/

Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions

https://www.cell.com/cell/fulltext/S0092-8674(22)01127-8

Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568762/

NAD+ Helps Natural Killer Cells to Fight Cancer

Cancer fighting requires cellular energy.

https://www.lifespan.io/news/nad-helps-natural-killer-cells-to-fight-cancer/

Losartan – Study reveals how to activate the immune system’s natural killer cells to protect against cancer and other diseases

https://www.sciencedaily.com/releases/2022/03/220316145739.htm

https://www.science.org/doi/10.1126/sciadv.abk3327

Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis

https://www.sciencedirect.com/science/article/pii/S0945053X22000397

https://reader.elsevier.com/reader/sd/pii/S0945053X22000397

Creating MHC-restricted neoantigens with covalent inhibitors that can be targeted by immune therapy

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-1074/709728/Creating-MHC-restricted-neoantigens-with-covalent

New Research: Tumor Cells Can Manipulate the Body’s Natural Antibody Response to Triple Negative Breast Cancer

https://news.christianacare.org/2022/04/new-research-tumor-cells-can-manipulate-the-bodys-natural-antibody-response-to-triple-negative-breast-cancer/

Scientists find the cause of severe COVID symptoms

Anticancer effects of herbal medicines in pancreatic ductal adenocarcinoma through modulation of steroid hormone response proteins

https://www.nature.com/articles/s41598-022-14174-1

A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis therapy

https://www.nature.com/articles/s41467-022-32486-8

Nivolumab Plus Ipilimumab Vs. Chemotherapy: Survival Outcome

Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02599-4

FDA Approves New Immunotherapy Combination To Treat Advanced Liver Cancer

https://www.mskcc.org/news/fda-approves-new-immunotherapy-combination-treat-advanced-liver

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

https://www.nature.com/articles/s41467-020-15795-8

Compound in pomegranates may help fight colon cancer