Articles and science papers (unsorted part 2.5)

How antibiotics may shut down cancer metastasis

https://www.fiercebiotech.com/research/how-antibiotics-may-shut-down-cancer-metastasis

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

https://www.nature.com/articles/s41586-022-04898-5

Bay leaf / LAURELArtecanin of Laurus nobilis is a novel inhibitor of SARS-CoV-2 main protease with highly desirable druglikeness

https://www.tandfonline.com/doi/abs/10.1080/07391102.2022.2030801

Playing With Fire: A Lab-Made Frankenstein COVID-19 Virus By Boston University

https://www.zerohedge.com/medical/playing-fire-lab-made-frankenstein-covid-19-virus-boston-university

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?

https://link.springer.com/article/10.1007/s12035-021-02696-0

Immunomodulatory and therapeutic implications of vitamin D in the management of COVID-19

https://www.tandfonline.com/doi/full/10.1080/21645515.2022.2025734

CBGA / CBDA – Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.

https://pubs.acs.org/doi/full/10.1021/acs.jnatprod.1c00946

Phytoconstituents from Moringa oleifera fruits target ACE2 and open spike glycoprotein to combat SARS-CoV-2: An integrative phytochemical and computational approach

https://onlinelibrary.wiley.com/doi/full/10.1111/jfbc.14062

Research Team Finds New Species of Coronaviruses in Some Unexpected Places

Research Team Finds New Species of Coronaviruses in Some Unexpected Places

Disulfiram – Gasdermin-D activation by SARS-CoV-2 trigger NET and mediate COVID-19 immunopathology

https://www.medrxiv.org/content/10.1101/2022.01.24.22269768v1

Coronapod: Why T cells have been overlooked

The ‘killer’ immune cells that attack the Omicron variant but are often forgotten

https://www.nature.com/articles/d41586-022-00238-9

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

https://www.biorxiv.org/content/10.1101/2022.01.24.477490v1

Ginseng, a promising choice for SARS-COV-2

https://www.sciencedirect.com/science/article/pii/S1226845322000033

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK

Inhaled budesonide improves time to recovery, with a chance of also reducing hospital admissions or deaths (although our results did not meet the superiority threshold), in people with COVID-19 in the community who are at higher risk of complications.

https://www.thelancet.com/article/S0140-6736(21)01744-X/fulltext

Research teases out connection between diet, immune response, gut bacteria and multiple sclerosis

https://www.news-medical.net/news/20220127/Research-teases-out-connection-between-diet-immune-response-gut-bacteria-and-multiple-sclerosis.aspx

UK INFECTION RATES AMONG BOOSTED ARE HIGHER vs THE UNVAXXED IN ALL ADULT COHORTS & RISING FASTER IN MOST.

Boosted & unvaxxed of all ages continue to get infected & spread – and in most cohorts, the boosted much moreso – rendering vaxx passports & mandates pointless.

New Treatment Helps Frogs Regenerate Limbs With Functioning Nerves in Just 18 Months

https://www.sciencealert.com/scientists-have-developed-a-treatment-to-help-frogs-regenerate-limbs-in-just-18-months

Cancer Drug Flushes Out Latent HIV, Exciting New Study Finds

The new study suggests that pembrolizumab, an immunotherapy drug which has transformed the treatment of melanoma and other cancers, might also be able to reverse HIV latency, flushing the virus out of hiding.

https://www.sciencealert.com/cancer-drug-flushes-out-dormant-hiv-small-study-finds

Could Long-Dead Bacteria Be the Culprit Behind Lingering Lyme Symptoms?

Ivermectin !!!

Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics

Nirmatrelvir (Paxlovid), MPro 13b, and Lopinavir displayed increased effectiveness and efficacy, while Ivermectin showed the best result against Omicron.

https://arxiv.org/abs/2201.08176

Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526435/

Remarkable images show how just one dose of experimental cancer treatment shrunk huge tumours in mice

https://www.dailymail.co.uk/health/article-10444667/Remarkable-images-just-one-dose-experimental-cancer-treatment-shrunk-tumours-mice.html

Cancer outbreak and treatment for malignant cancer cells in a human body caused by carcinogens and g...

Fasting may help some cancer drugs work better

https://www.inverse.com/mind-body/fasting-cancer-treatment

Pancreatic cancer cells feed off hyaluronic acid

Often found in beauty products and wellness supplements, hyaluronic acid attracts and retains water well. It’s also a major player in the physiology of pancreatic tumors.

https://labblog.uofmhealth.org/lab-report/pancreatic-cancer-cells-feed-off-hyaluronic-acid

Chickpeas – Visceral fat: The lipid-lowering food that depletes fat storage ‘significantly’ in weeks

https://www.express.co.uk/life-style/health/1556752/how-to-lose-visceral-fat-chickpeas-weeks

Why we are living in an era of unnatural selection

https://www.bbc.com/future/article/20220125-how-humans-are-changing-evolution

Magnesium may prime the immune system to fight cancer and infections

  • Magnesium deficiency has links to a wide range of diseases.
  • Researchers have now shown in mice how magnesium improves the ability of the immune system to eliminate infected and cancerous cells.
  • Their analysis of data from clinical studies also suggests that low serum levels of the substance are associated with worse outcomes in cancer treatment.
  • They plan to investigate the possible benefits of magnesium supplementation during cancer therapy in future clinical trials.

https://www.medicalnewstoday.com/articles/magnesium-may-prime-the-immune-system-to-fight-cancer-and-infections

Drug used to treat cancer may also help fight HIV, Australian research finds

Pembrolizumab has revolutionised treatments of cancers, including melanoma, and makes HIV vulnerable to attack

https://www.theguardian.com/society/2022/jan/27/drug-used-to-treat-cancer-may-also-help-fight-hiv-australian-research-finds

Antimicrobial Resistance Linked to 1.2 Million Global Deaths in 2019

https://www.medscape.com/viewarticle/966910

Forscher lassen Fröschen Beine nachwachsen

Einige Tiere können verloren gegangene Körperteile nachwachsen lassen. Krallenfrösche gehören natürlicherweise nicht dazu. Aber mit Hilfe von Medikamenten bringen Forschende sie trotzdem dazu. Könne das auch bei menschlichen Armen und Beinen gelingen?

https://www.n-tv.de/wissen/Forscher-lassen-Froeschen-Beine-nachwachsen-article23085602.html

Pfizer exec calls Israel ‘a sort of laboratory’ for COVID vaccines

Health officials deny country signed an exclusive deal with pharma giant, noting that Moderna shots are also administered; pharmaceutical company clarifies comments

https://www.timesofisrael.com/pfizer-exec-calls-israel-a-sort-of-laboratory-for-covid-vaccines/

Cannabis Compound CBD Stops Coronavirus in Test Tube, but Can It Treat COVID?

https://www.medscape.com/viewarticle/967194

Active Ingredient in Cannabis Protects Aging Brain Cells

CBN can protect nerve cells from oxidative damage, a major pathway to cell death.

Large, Peer-Reviewed Research Study Proves Ivermectin Works Against COVID-19

https://www.zerohedge.com/covid-19/large-peer-reviewed-research-study-proves-ivermectin-works

Antibody response 18 months after SARS-CoV-2 infection in vaccinated and unvaccinated individuals

https://www.news-medical.net/news/20220124/Antibody-response-18-months-after-SARS-CoV-2-infection-in-vaccinated-and-unvaccinated-individuals.aspx

The deadly combination behind the surge of ‘superbug’ fungus outbreaks

Candida auris is a notoriously deadly and drug-resistant yeast—and new cases are rising in hospitals nationwide.

Candida auris is a notoriously deadly and drug-resistant yeast—and new cases are rising in hospitals nationwide.

Genetic Research Shows Rapid Immune Response in Children Protects Them From COVID-19

Genetic Research Shows Rapid Immune Response in Children Protects Them From COVID-19

In rare cases, coronavirus vaccines may cause Long Covid–like symptoms

Brain fog, headaches, blood pressure swings are being probed by NIH and other researchers

https://www.science.org/content/article/rare-cases-coronavirus-vaccines-may-cause-long-covid-symptoms

DNA Mutations Are Not Random: New Research Radically Changes Our Understanding of Evolution

DNA Mutations Are Not Random: New Research Radically Changes Our Understanding of Evolution

Five reasons why COVID herd immunity is probably impossible

Even with vaccination efforts in full force, the theoretical threshold for vanquishing COVID-19 looks to be out of reach.

https://www.nature.com/articles/d41586-021-00728-2

Ivermectin Could Destroy Justification For Lockdowns And Vaccine Mandates

https://www.zerohedge.com/covid-19/ivermectin-could-destroy-justification-lockdowns-and-vaccine-mandates

Herd Immunity a Mirage? High Protection Didn’t Stop Surges

https://www.nature.com/articles/d41586-021-00728-2

Frequent Booster Doses Could Eventually Weaken Immune System

https://www.medscape.com/viewarticle/966991Frequent Booster Doses Could Eventually Weaken Immune System: European Medicines Agency

https://www.sciencedaily.com/releases/2022/01/220119121455.htm Magnesium sensing via LFA-1 regulates CD8+ T cell effector functionMagnesium sensing via LFA-1 regulates CD8+ T cell effector functionwe show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8+ T cells, thereby augmenting calcium flux, signal transduction, metabolic reprogramming, immune synapse formation, and, as a consequence, specific cytotoxicity. Accordingly, magnesium-sufficiency sensed via LFA-1 translated to the superior performance of pathogen- and tumor-specific T cells, enhanced effectiveness of bi-specific T cell engaging antibodies, and improved CAR T cell function. Clinically, low serum magnesium levels were associated with more rapid disease progression and shorter overall survival in CAR T cell and immune checkpoint antibody-treated patients. https://www.cell.com/cell/fulltext/S0092-8674(21)01561-0

Viruses unleashed into a woman’s wound to slay superbug in her leg

The viruses were bacteriophages, meaning viruses that infect bacteria.

https://www.livescience.com/superbug-slayed-with-phage-therapy-and-antibiotics

Increasing the capacity of the immune system to kill cancer cells

https://medicalxpress.com/news/2022-01-capacity-immune-cancer-cells.html

Researchers reduce breast cancer metastasis in animal models by modifying tumor electrical properties

Amiodarone, an ion channel blocker approved for other diseases, significantly inhibits tumor cell invasion

https://www.eurekalert.org/news-releases/939736

Immunity in Omicron SARS-CoV-2 breakthrough COVID-19 in vaccinated adults

https://www.medrxiv.org/content/10.1101/2022.01.13.22269213v1

Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer

https://www.nature.com/articles/s41523-021-00229-5

A systematic review of cases of CNS demyelination following COVID-19 vaccination

https://www.sciencedirect.com/science/article/pii/S0165572821002927

Ivermectin as an endectocide may boost control of malaria vectors in India and contribute to elimination

https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-021-05124-3

UK HSA data shows infection rate growth correlates with vaccination rate for age cohorts >50. The more highly vaxxed an age cohort is – whether fully vaxxed or boosted – the faster the infection rate growth. Infectn rate growth in the unvaxxed is fairly consistent across cohorts.

SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00003-9

Antikythera Mechanism: They found the password and unlocked its secrets for the first time

Superbug breakthrough made in antibiotic-resistant pathogen that could kill 10 million

SCIENTISTS may have unlocked the key to combating superbugs that have become resistant to common frontline antibiotics.

https://www.express.co.uk/news/science/1549865/superbug-breakthrough-scientists-discover-new-approach-antibiotic-resistant-bacteria

In Deutschland erkranken jährlich eine halbe Million Menschen neu an Krebs

Krebs kostet jährlich weltweit 250 Millionen Lebensjahre. In Deutschland sterben viermal so viele Menschen an Krebs als an Covid-19. Der Bedarf an besseren Therapien bleibt riesig.

https://www.handelsblatt.com/unternehmen/industrie/krebs-in-deutschland-erkranken-jaehrlich-eine-halbe-million-menschen-neu-an-krebs/27956898.html

Deciphering the potential anti-COVID-19 active ingredients in Andrographis paniculata (Burm. F.) Nees by combination of network pharmacology, molecular docking, and molecular dynamics

An andrographolide sulfonates preparation, named Xiyanping injection in Chinese, which was prepared from the aqueous extract of Andrographis paniculata (Burm. F.) Nees, showed favorable therapeutic effectiveness on COVID-19, suggesting A. paniculata could contain powerful therapeutic ingredients against COVID-19.

https://pubs.rsc.org/en/content/articlehtml/2021/ra/d1ra06487h

Potent Inhibitory Activities of the Adenosine Analogue Cordycepin on SARS-CoV-2 Replication

https://pubs.acs.org/doi/full/10.1021/acsomega.1c05998

Cancer: The drug linked to a ‘doubled’ risk of cancer – millions prescribed in UK annually

https://www.express.co.uk/life-style/health/1550547/cancer-risk-proton-pump-inhibitors-stomach

This is the ‘worst food ingredient for your immune system’—especially during Covid, says immunologist

https://www.cnbc.com/2022/01/15/this-is-the-worst-ingredient-for-your-immune-system-says-immunologist-and-health-expert.html

How pathogens can turn off mitochondrial defense mechanisms

https://phys.org/news/2022-01-pathogens-mitochondrial-defense-mechanisms.html

A Common Virus Can Trigger Multiple Sclerosis, According to Huge New Study

Multiple sclerosis – an autoimmune disease that affects the brain and spinal cord – may emerge after infection with Epstein-Barr virus (EBV).

https://www.sciencealert.com/military-data-provides-compelling-evidence-catching-mono-can-trigger-multiple-sclerosis

Spätfolge einer Virusinfektion Wichtigste Ursache für Multiple Sklerose gefunden

Die Wissenschaft hat das Epstein-Barr-Virus schon länger im Verdacht, Multiple Sklerose auszulösen. Nun können Forschende der Harvard-Universität den Beweis liefern. Für die Fachleute ein Meilenstein.

https://www.n-tv.de/wissen/Wichtigste-Ursache-fuer-Multiple-Sklerose-gefunden-article23056938.html

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

https://pubs.acs.org/doi/10.1021/acs.jnatprod.1c00946

“Doomed To Fail” – Top Immunologist Blasts Global COVID Response Driven By “False Propaganda”

https://www.zerohedge.com/covid-19/doomed-fail-top-immunologist-blasts-global-covid-response-driven-false-propaganda

Mittlerweile 10 Jahre alt, gelöscht und kaum noch zu finden. Corona

https://www.facebook.com/stephan.stahl.1966/posts/pfbid0cRwQjvsgyEiiscQPN4dxXRT15QGHQvcns7hiKpCJuBEaYTKuGy81jFG5cX69pAQsl

CBDASome marijuana compounds can block coronavirus from entering cells

https://nypost.com/2022/01/12/marijuana-compounds-can-block-coronavirus-from-entering-cells-study/

CBD might help prime cells against COVID

CBD in therapeutic amounts seem to increase the innate anti-viral system of cells readiness to respond to viral infection

https://uwaterloo.ca/news/media/cbd-might-help-prime-cells-against-covid

Ivermectin ‘Works Throughout All Phases’ Of COVID According To Leaked Military Documents

https://www.zerohedge.com/covid-19/hidden-military-documents-reveal-nih-intent-create-sars-cov-2-using-gain-function-research

https://leadstories.com/hoax-alert/2021/09/fact-check-no-evidence-fda-cdc-who-hide-ivermectin-efficacy-data.html

More Vitamin D Not Better for Reducing Cancer or CVD Incidence

https://www.medscape.com/viewarticle/966333

Universitätsprofessor: mRNA-Substanzen sind keine Impfstoffe, Impfzwang ist falsch!

Adding single type of bacteria to gut microbiome boosted anti-tumor immunity in mice

A bacterium common in the mouse gut microbiome can charge up the immune system to fight cancer cells in the colon, researchers from the University of Pittsburgh School of Medicine report today in the journal Immunity.

The study showed that bacterium Helicobacter hepaticus boosted adaptive immune response and prompted selective activation of Helper T cells and antibody-producing B cells, causing colon tumors to shrink and lengthening survival in mice.

https://www.sciencedaily.com/releases/2021/12/211202113459.htm

Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts

https://www.nature.com/articles/s41467-021-27674-x

Niclosamide Suppresses Migration and Invasion of Human Osteosarcoma Cells by Repressing TGFBI Expression via the ERK Signaling Pathway

https://www.mdpi.com/1422-0067/23/1/484

Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers

https://www.mdpi.com/1422-0067/23/1/519

SAGE – High cholesterol: The 57p herb that causes levels to plummet by almost 20% – ‘effective’

https://www.express.co.uk/life-style/health/1547677/high-cholesterol-foods-diet-sage-levels-how-to-lower

T cells from common colds cross-protect against infection with SARS-CoV-2

https://www.imperial.ac.uk/news/233018/cells-from-common-colds-cross-protect-against/

Eucalyptus – Targeting glucose metabolism by using bioactive 1-8 cineole for treatment of SARS-CoV : insights from in-silico studies 2019

https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/385

Azithromycin 500, Ivermectin 12 mg, Vitamin D3, Vitamin C, Zinc, Vitamin B complex and paracetamol tablets are available for those above 12 years.

https://www.hindustantimes.com/cities/others/covid19-medicine-kits-distribution-begins-in-varanasi-101641063721395.html

Common herbs may hold key to breakthrough tumor-killing cancer treatment

Thymol, carvacrol, and thymohydroquinone make up the distinctive, Mediterranean flavors of thyme, oregano, and other plants in the Lamiaceae family. As well as being a culinary staple, the herbs are antibacterial, anti-inflammatory and they are rich in antioxidants. Out of the three chemicals, thymohydroquinone piqued the scientists’ interest because of its anti-cancer properties.

Cyprus Finds Covid-19 Infections That Combine Delta and Omicron

https://www.bloomberg.com/news/articles/2022-01-08/cyprus-finds-covid-19-infections-that-combine-delta-and-omicron

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

https://www.news-medical.net/news/20211129/Study-uncovers-mechanism-for-insensitivity-to-key-antimalarial-drug-in-new-pathogen-variant.aspx

Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum

https://www.sciencedirect.com/science/article/pii/S2213231721003372

Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants

https://www.sciencedirect.com/science/article/pii/S0378874121002439

Disulfiram, a treatment for alcoholism, may cut severe SARS-CoV-2 infection, reduce likelihood of dying from COVID-19.

  • As the COVID-19 pandemic continues, there’s a need for new and better treatments for people infected with SARS-CoV-2 who develop COVID-19
  • In a new study, a well-known and widely available drug called disulfiram, used to treat alcoholism, shows potential as a treatment for COVID-19
  • In the retrospective analysis, veterans taking the drug for alcoholism were less likely to be infected with SARS-CoV-2 and less likely to die from COVID-19
  • The researchers hope their study will generate support for phase 3 clinical trials testing the drug in patients with severe COVID-19

Disulfiram, a treatment for alcoholism, may cut severe SARS-CoV-2 infection, reduce likelihood of dying from COVID-19

Zuckerlose, fettreiche Kost sowie Fasten sollen helfen, Tumoren zu bekämpfen. Doch wie wirksam ist eine solche Ernährung wirklich im Kampf gegen Krebs? Und welche Risiken birgt sie?

https://www.spektrum.de/news/ernaehrung-bei-krebs-der-zucker-darf-bleiben/1963054

Deutsche Forscher finden Substanz, die Metastasenbildung unterdrückt

Wenn Krebs Metastasen bildet, schwinden die Überlebenschancen von Patienten. Deutsche Krebsforscher haben nun einen Mechanismus gefunden, der erklärt, warum sie häufig erst nach Entfernung des Haupttumors auftreten – und welche Substanz das verhindert.

https://www.focus.de/gesundheit/news/hoffnung-fuer-die-krebsmedizin-meilenstein-in-der-krebsforschung-deutsche-forscher-finden-molekuel-das-metastasen-verhindert_id_171603799.html

Compound fights triple-negative breast cancer

FILE - This undated fluorescence-colored microscope image made available by the National Institutes of Health in September 2016 shows a culture of human breast cancer cells. (Ewa Krawczyk/National Cancer Institute via AP)
FILE – This undated fluorescence-colored microscope image made available by the National Institutes of Health in September 2016 shows a culture of human breast cancer cells. (Ewa Krawczyk/National Cancer Institute via AP) (Ewa Krawczyk, NCI\Georgetown Lombardi CCC, NIH)

SAN ANTONIO, Texas – October is Breast Cancer Awareness Month. Triple-negative breast cancer is aggressive, and if not caught early, has a five-year survival rate of only 12%.

Until now, doctors didn’t have much to fight the disease. But a new compound called ERX-41 is showing promise in knocking down triple-negative and other breast cancers.

https://14a0aa9373a909d44010dfced2817cdf.safeframe.googlesyndication.com/safeframe/1-0-38/html/container.html

“What we found is ERX-41 binds to a new therapeutic target that is LipA,” Vadlamudi explained.

Once ERX-441 binds to the LipA gene, then, the cancer senses defective cells and dies off.

“They accumulate in the lumen, and the lumen sends a signal that something is wrong — stop everything,” Vadlamudi added.

Researchers have found a breakthrough in mice. Normal breast cells are not affected by ERX-41, and there is no toxicity to the patient.

ERX-41 has been effective in knocking down cancer in mice in 60 days. He also said the compound is likely to be effective against other lethal cancers like pancreatic, ovarian and glioblastoma. Researchers expect human clinical trials to begin next year.

Researchers find the root of immunosuppression and chemoresistance in TNBC tumors

https://www.news-medical.net/news/20221101/Researchers-find-the-root-of-immunosuppression-and-chemoresistance-in-TNBC-tumors.aspx

Faktenchecks von Reuters bei Facebook. Zusammenhang zwischen Reuters und Pfizer.

5-gram increase in fiber intake may lower melanoma progression by 30%

  • An observational study finds a link between high dietary fiber intake and better responses to immune therapy for melanoma, a type of skin cancer.
  • Every 5-gram (g) increase in daily consumption of fiber was associated with a 30% lower risk of cancer progression or death.
  • The benefit was greatest in people who did not take probiotic supplements.
  • Those who responded well to treatment tended to have more of two particular types of bacteria in their gut.

Taking high-dose vitamin D supplements for five years did not affect the incidence of cardiovascular disease or cancer

https://www.sciencedaily.com/releases/2022/01/220105111427.htm

New research shows gene exchange between viruses and hosts drives evolution

The first comprehensive analysis of viral horizontal gene transfer (HGT) illustrates the extent to which viruses pick up genes from their hosts to hone their infection process, while at the same time hosts also co-opt useful viral genes.

https://phys.org/news/2022-01-gene-exchange-viruses-hosts-evolution.html

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

https://www.sciencedirect.com/science/article/pii/S2211124721014340

Potential Thai Herbal Medicine for COVID-19

Certain medicinal plants which possess antiviral replication and blockage of the affinity binding between S-protein of SARS-CoV-2 and ACE2 receptor include Andrographis paniculata, Boesenbergia rotunda, Zingiber officinale, Phyllanthus amarus, Phylanthus emblica, Glycyrrhiza glabra, and Citrus medica. These plants were summarized for their potential in COVID-19 treatment. Integrating Thai Traditional Medicine principles with contemporary COVID-19 treatment mechanisms would certainly have valuable provide more efficient clinical therapy.

http://18.141.44.152/index.php/amjam/article/view/253

Turning Toxoplasma Against Cancer

https://www.the-scientist.com/news-opinion/turning-toxoplasma-against-cancer-69575

Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement

https://www.the-scientist.com/news-opinion/turning-toxoplasma-against-cancer-69575

Friendly fire: Using viruses to kill tumors and fight breast cancer

Oncolytic viruses have the power to make the tumor more visible to the immune system and mark the area of attack. It is this anti-tumor immune activation that has the potential to induce long-term responses in patients.

Friendly fire: Using viruses to kill tumors and fight breast cancer

Antitumor Effects of Natural Compounds Derived from Allium sativum on Neuroblastoma

https://www.mdpi.com/2076-3921/11/1/48

Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential

https://www.mdpi.com/2072-6694/14/1/76

Anticancer breakthrough from BGU scientists could change how we treat the disease

Their discovery focused on a naturally occurring peptide from the non-coding region of mRNA.

https://www.jpost.com/science/article-691365

Lymphoma Cell Metabolism May Provide New Cancer Target

https://news.weill.cornell.edu/news/2022/01/lymphoma-cell-metabolism-may-provide-new-cancer-target

Medical cannabis for severe treatment resistant epilepsy in children: a case-series of 10 patients

https://bmjpaedsopen.bmj.com/content/5/1/e001234

Photosensitization of a subcutaneous tumour by the natural anthraquinone parietin and blue light

https://www.nature.com/articles/s41598-021-03339-z

Antiproliferative, Antibacterial and Antifungal Activity of the Lichen Xanthoria parietina and Its Secondary Metabolite Parietin

https://www.mdpi.com/1422-0067/16/4/7861

Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India

https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0247163&fbclid=IwAR1WBQBzYSA_7_GD9wNCaGBXO2VWzG1Z79b21x3e47Zxp5JkjCPcEiWjka8

Cyathus striatus Extract Induces Apoptosis in Human Pancreatic Cancer Cells and Inhibits Xenograft Tumor Growth In Vivo

https://www.mdpi.com/2072-6694/13/9/2017

Benefits of Garlic for Fighting Cancer and the Common Cold

https://nutritionfacts.org/video/benefits-of-garlic-for-fighting-cancer-and-the-common-cold/

Metabolite from pomegranates may help fight colorectal cancer

“The ellagitannins are predominantly found in pomegranates but also strawberries, raspberries, and nuts, most notably walnuts,” he explained.

https://www.medicalnewstoday.com/articles/metabolite-from-pomegranates-may-help-fight-colorectal-cancer

Preventing Cancer with Turmeric: The Whole is Better than the Sum of its Parts

https://reinventionjournal.org/index.php/reinvention/article/view/939

Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase

EGCG can specifically inhibit the proliferation of KRAS-mutated lung cancer cell lines without affecting KRAS wild-type lung cancer cell lines.

https://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.2c00163

Multi-Target Potential of Berberine as an Antineoplastic and Antimetastatic Agent: A Special Focus on Lung Cancer Treatment

https://www.mdpi.com/2073-4409/11/21/3433

Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics

https://www.sciencedirect.com/science/article/abs/pii/S000629522200421X

Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance:

An Autophagy-Based Perspective

https://www.mdpi.com/2218-273X/12/11/1565

Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton’s Lymphoma: An in vitro and in vivo studyMoringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton’s Lymphoma: An in vitro and in vivo study

https://www.sciencedirect.com/science/article/abs/pii/S0378874122008881

Resveratrol inhibits proliferation and induces apoptosis via the Hippo/YAP pathway in human colon cancer cells

https://www.sciencedirect.com/science/article/abs/pii/S0006291X22014887

Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro

https://link.springer.com/article/10.1186/s13046-014-0092-7

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255490/

Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells

https://www.kjpp.net/journal/view.html?doi=10.4196/kjpp.2022.26.5.377

Fenbendazole induces cell cycle arrest in colorectal cancer cells and patient-derived colon cancer organoids

https://aacrjournals.org/cancerres/article/82/12_Supplement/2313/701049

The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2

https://www.mdpi.com/1999-4915/13/3/425

HIV drug shows promise against metastatic cancer

The drug used in the study was lamivudine, a reverse transcriptase inhibitor.

The trial included 32 patients with advanced metastatic colon cancer whose disease progressed despite four lines of previous cancer treatments. The first nine patients received the standard HIV-approved dose of lamivudine.

“After giving them only this one drug — nothing else — we saw signs of disease stability,” says co-senior author David T. Ting of the Mass General Cancer Center. After adjusting the dosing four-fold, another 23 patients received lamivudine therapy where it was highly tolerated.

HIV drug shows promise against metastatic cancer

Old drugs offer new ways of treating bowel cancer

https://www.sciencedaily.com/releases/2022/10/221011183859.htm

Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis

https://link.springer.com/article/10.1007/s00280-004-0927-6

Ferroptosis in Cancer Treatment: Another Way to Rome

https://www.frontiersin.org/articles/10.3389/fonc.2020.571127/full

Bromelain inhibits SARS‐CoV‐2 infection via targeting ACE‐2, TMPRSS2, and spike protein

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811777/

Statins: a repurposed drug to fight cancer

https://link.springer.com/article/10.1186/s13046-021-02041-2

SARS-CoV-2 Omicron’s newest subvariant BQ.1.1 shows extraordinary immune evasion potential against vaccine sera

https://www.news-medical.net/news/20221104/SARS-CoV-2-Omicrons-newest-subvariant-BQ11-shows-extraordinary-immune-evasion-potential-against-vaccine-sera.aspx

Vitamin C improves immunogenic properties of dendritic cells, study shows

Spanish researchers have discovered that vitamin C may hold the key to improving the efficacy of dendritic cell-derived anticancer therapies.

https://www.drugtargetreview.com/news/106255/vitamin-c-improves-immunogenic-properties-of-dendritic-cells-study-shows/

Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac941/6777795

ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific manner

https://www.nature.com/articles/s42003-022-04170-6

Vaccination with senescent cells reduced tumor formation in mice

https://www.miragenews.com/vaccination-with-senescent-cells-reduced-tumor-888261/

Drugging p53 in cancer: one protein, many targets

https://www.nature.com/articles/s41573-022-00571-8

Compound in passion fruit could be used to treat stomach cancer, Chinese study finds

Seeds of the fruit contain piceatannol, which was found to inhibit cell proliferation and boost autophagic activity Study also suggests the compound may be more effective when combined with a targeted cancer drug

https://www.scmp.com/news/china/science/article/3198465/compound-passion-fruit-could-be-used-treat-stomach-cancer-chinese-study-finds

The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1

https://www.nature.com/articles/6600197

Scientists made mini brains and infected them with coronavirus. What they saw could explain Long COVID

https://finance.yahoo.com/news/scientists-made-mini-brains-infected-093000490.html

Did EBOLA leak from a lab? Scientists claim accident at US-funded biofacility may have caused 2014 West Africa outbreak

https://www.dailymail.co.uk/health/article-11383611/Ebola-leaked-biofacility-causing-2014-West-Africa-outbreak-scientists-claim.html

Could coffee offer protection from catching COVID-19?

https://phys.org/news/2022-11-coffee-covid-.html

Will Long COVID Research Provide Answers for Poorly Understood Diseases Like ME/CFS?

https://medicine.yale.edu/news-article/will-long-covid-research-provide-answers-for-poorly-understood-ailments-like-chronic-fatigue/

Oral FMT on Par With Colonic FMT for Recurrent C difficile

https://www.medscape.com/viewarticle/983251

A Woman Had Cancer 12 Times by Age 36. Her Genes Showed Something Never Seen Before

https://www.sciencealert.com/a-woman-had-cancer-12-times-by-age-36-her-genes-showed-something-never-seen-before

Like a “fire in the brain”: COVID can cause brain inflammation that mimics Parkinson’s symptoms

Research shows COVID causes damage similar to Parkinson’s disease, but experts may have found a way to shut it off

https://www.salon.com/2022/11/02/like-a-fire-in-the-brain-can-cause-brain-inflammation-that-mimics-parkinsons-symptoms/

Magic mushrooms’ psilocybin can alleviate severe depression when used with therapy

Nearly third of patients on largest trial using psychedelic compound went into rapid remission

https://www.theguardian.com/science/2022/nov/02/magic-mushrooms-psilocybin-alleviate-severe-depression-alongside-therapy

Multi-Target Potential of Berberine as an Antineoplastic and Antimetastatic Agent: A Special Focus on Lung Cancer Treatment

https://www.mdpi.com/2073-4409/11/21/3433

Preventing Cancer with Turmeric: The Whole is Better than the Sum of its Parts

https://reinventionjournal.org/index.php/reinvention/article/view/939/963

Metabolite from pomegranates may help fight colorectal cancer

  • Researchers investigated the effects of a metabolite called urolithin A on colorectal cancer.
  • Urolithin A is the result of gut bacteria metabolizing a type of polyphenol found in pomegranates.
  • They found that, in mouse models, the metabolite limits tumor growth and acts synergistically with immunotherapy.
  • The researchers noted that further research is needed to better understand the underlying mechanisms and see if the findings can be replicated in humans.

https://www.medicalnewstoday.com/articles/metabolite-from-pomegranates-may-help-fight-colorectal-cancer

Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation

https://www.sciencedirect.com/science/article/pii/S1936523319302542

Combination therapy with Azithromycin, Pentoxifylline and Dexamethasone shows Complete Recovery in Severe COVID 19: Case Series of Patients in First …

https://www.researchsquare.com/article/rs-762889/latest.pdf

Treatment of hepatocarcinoma with celecoxib and pentoxifylline: a case report

https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDREVISTA=46&IDARTICULO=84084&IDPUBLICACION=8065

LICORICEGlycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach

GA inhibits melanoma growth by normalizing progressive tumor microenvironment.•

GA induces apoptosis and modulates inflammatory cytokines from Th2 to Th1 in melanoma.•

GA inhibits pSTAT3 mediated immune suppression of Tregs and MDSCs in melanoma.•

Combinatorial immunotherapy of GA and Mw restricts advanced stage melanoma growth.

https://www.sciencedirect.com/science/article/pii/S1567576920310456

NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer

NF-κB c-Rel regulates the transcriptional landscape of activated Tregs•

c-Rel activity in Tregs restricts anti-tumor responses•

Chemical c-Rel inhibition reduces melanoma growth and potentiates anti-PD-1 therapy

https://www.sciencedirect.com/science/article/pii/S0092867417308929

Treg programming and therapeutic reprogramming in cancer

https://onlinelibrary.wiley.com/doi/full/10.1111/imm.13058

Pentoxifylline: A Drug with Antiviral and Anti-Inflammatory Effects to Be Considered in the Treatment of Coronavirus Disease

https://europepmc.org/article/med/33049737

Pentoxifylline and Oxypurinol: Potential Drugs to Prevent the “Cytokine Release (Storm) Syndrome” Caused by SARS-CoV-2?

https://www.ingentaconnect.com/content/ben/cpd/2020/00000026/00000035/art00014

Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19

https://www.sciencedirect.com/science/article/pii/S030698772031032X

A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19

https://link.springer.com/article/10.1007/s10787-022-00993-1

Pentoxifylline induces caspase-dependent apoptosis in colorectal cancer cells

https://www.sciencedirect.com/science/article/pii/S235291482200140X

Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.631