Articles and science papers (unsorted part 2.6)

A Cephalopod Has Passed a Cognitive Test Designed For Human Children

https://www.sciencealert.com/cuttlefish-can-pass-a-cognitive-test-designed-for-children

The mechanisms of action of ivermectin against SARS-CoV-2

https://www.nature.com/articles/s41429-021-00491-6

Researchers found an inexpensive repurposed drug called fluvoxamine can save the lives of COVID-19 patients and cut hospital admissions by up to 30%.

First Report of Horizontal Gene Transfer Between Plant and Animal

Whiteflies overcome a toxin in plants they eat through the use of the plant’s own genetic protection, likely ferried from plant to insect millions of years ago by a virus.

https://www.the-scientist.com/news-opinion/first-report-of-horizontal-gene-transfer-between-plant-and-animal-68597

Horizontal gene transfer in the acquisition of novel traits by metazoans

https://royalsocietypublishing.org/doi/full/10.1098/rspb.2013.2450

Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

https://elifesciences.org/articles/60176

Coronavirus can persist for months after traversing entire body

https://eu.detroitnews.com/story/life/wellness/2021/12/26/study-coronavirus-can-persist-months-after-traversing-entire-body/9019634002/

The Role of Bovine Leukemia Virus in Breast Cancer

As many as 37 percent of human breast cancer cases may be attributable to exposure to bovine leukemia virus.

https://nutritionfacts.org/video/the-role-of-bovine-leukemia-virus-in-breast-cancer/

Could Viagra Help Prevent Alzheimer’s?

https://www.medscape.com/viewarticle/964389

16. Sicherheitsbericht des PEI: Hepatitis nach der Impfung und der Schein vom „sicheren Boostern“

https://corona-blog.net/2021/12/26/16-sicherheitsbericht-des-pei-hepatitis-nach-der-impfung-und-dem-schein-vom-sicheren-boostern/

Han lab developing light-activated immune cell therapy for cancers

Research may lead to better, safer immunotherapy for next generation precision medicine

https://www.umassmed.edu/news/news-archives/2021/12/han-lab-developing-light-activated-immune-cell-therapy-for-cancers/

Cancer cells drain energy from immune cells

  • Researchers found that cancer cells use straw-like nanotubes to siphon mitochondria from immune cells, essentially draining their energy.
  • Inhibiting nanotube formation could make certain anticancer therapies more effective.

https://www.nih.gov/news-events/nih-research-matters/cancer-cells-drain-energy-immune-cells

A pandemic of the vaccinated or Ivermectin ignored?

https://www.thedesertreview.com/opinion/columnists/a-pandemic-of-the-vaccinated-or-ivermectin-ignored/article_2fb8e67c-4c89-11ec-8a97-a7954a7ae6dd.html

NiclosamideIvermectin combination to have the best synergy score

Synergistic Anti-SARS-CoV-2 Activity of Repurposed Anti-Parasitic Drug Combinations

https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/ppcovidwho-293327

Niclosamide suppresses T‑cell acute lymphoblastic leukemia growth through activation of apoptosis and autophagy

https://www.spandidos-publications.com/10.3892/or.2021.8241

First-line treatment with immune checkpoint inhibitor rather than BRAF and MEK leads to improved survival

1. Starting treatment with nivolumab/ipilimumab rather than dabrafenib/trametinib resulted in an improvement in 2-year overall survival (72% vs 52%)

2. The incidence of adverse events grade 3 or higher was relatively similar across all arms, although the events themselves differed.

EBC-46Team makes rare, natural cancer-fighting compound in the lab

Researchers have figured out how to make a powerful cancer-fighting compound that is naturally only found in a single tree species from a small rainforest region of Northeastern Australia.

The compound, designated EBC-46 and technically called tigilanol tiglate, works by promoting a localized immune response against tumors. The response breaks apart the tumor’s blood vessels and ultimately kills its cancerous cells.

Team makes rare, natural cancer-fighting compound in the lab

Sugar molecules as a target in cancer therapy

Cancer cells use sugar molecules on their surface to disable attacks by the body’s immune system. Researchers now report on how this mechanism can be neutralized.

https://www.sciencedaily.com/releases/2022/11/221107103218.htm

Epstein-Barr Virus-Positive Primary Diffuse Large B-cell Lymphoma of the Colon in a Patient With Human Immunodeficiency Virus

https://www.cureus.com/articles/122276-epstein-barr-virus-positive-primary-diffuse-large-b-cell-lymphoma-of-the-colon-in-a-patient-with-human-immunodeficiency-virus

Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress

https://www.mdpi.com/2218-273X/12/11/1600

Cell competition may explain cancer relapses, research suggests

https://www.utsouthwestern.edu/newsroom/articles/year-2022/november-cell-competition.html

Cancer Cells in Mice May Hitch a Ride with Bone-Healing Stem Cells

Researchers have long observed a connection between bone metastasis and remodeling, which might be due to a close connection between the two cell types.

https://www.the-scientist.com/news-opinion/cancer-cells-in-mice-may-hitch-a-ride-with-bone-healing-stem-cells-70732

Statins may prevent people from losing eyesight in later life

Scientists also found people prescribed diabetes drugs, such as insulin and anti-inflammatories, had lower risk of developing the condition

https://www.telegraph.co.uk/news/2022/11/08/statins-may-prevent-people-losing-eyesight-later-life/

Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer

https://www.nature.com/articles/s41467-022-33598-x

Beer hops compounds could help protect against Alzheimer’s disease

https://phys.org/news/2022-11-beer-compounds-alzheimer-disease.html

Did a Famous Doctor’s COVID Shot Make His Cancer Worse?

https://www.theatlantic.com/science/archive/2022/09/mrna-covid-vaccine-booster-lymphoma-cancer/671308/

Ivermectin induces cell cycle arrest and caspase-dependent apoptosis in human urothelial carcinoma cells

https://www.medsci.org/v19p1567.htm

Efficacy of ivermectin against colon cancer induced by dimethylhydrazine in male wistar rats

https://www.sciencedirect.com/science/article/pii/S1319016422001815

Ivermectin-induced cell death of cervical cancer cells in vitro a consequence of precipitate formation in culture media

https://www.sciencedirect.com/science/article/pii/S0041008X22002186

Ivermectin kills cancer cells via extensive changes in the endoplasmic reticulum structure

http://repository.ajou.ac.kr/handle/201003/21756

Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin

https://www.proquest.com/openview/0f4c85ef6965d95a823f9400043f865c/1

The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/

Ivermectin as an inhibitor of cancer stem‑like cells

https://www.spandidos-publications.com/10.3892/mmr.2017.8231

Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway

https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1251-7

Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs

https://www.sciencedirect.com/science/article/abs/pii/S0960894X19302781

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982461/

Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer

https://www.nature.com/articles/s41523-021-00229-5

Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

https://www.frontiersin.org/articles/10.3389/fphar.2021.717529/full

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

https://www.sciencedirect.com/science/article/abs/pii/S0006291X18302869

Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer

https://www.spandidos-publications.com/10.3892/ijmm.2021.5005

Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway

https://onlinelibrary.wiley.com/doi/full/10.1111/cpr.12543

Pyroptosis: A new frontier in cancer

https://www.sciencedirect.com/science/article/pii/S0753332219352175

Ivermectin induces autophagy-mediated cell death through the AKT/mTOR signaling pathway in glioma cells

https://portlandpress.com/bioscirep/article/39/12/BSR20192489/221237/Ivermectin-induces-autophagy-mediated-cell-death

Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630406/

Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting

https://link.springer.com/article/10.1007/s10787-021-00796-w

Ivermectin as a multifaceted drug in COVID-19: Current insights

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313054/

Comparative Risk of Myocarditis/Pericarditis Following Second Doses of BNT162b2 and mRNA-1273 Coronavirus Vaccines

https://www.sciencedirect.com/science/article/pii/S0735109722068243

How Supergenes Fuel Evolution Despite Harmful Mutations

Supergenes that lock inherited traits together are widespread in nature. Recent work shows that their blend of genetic benefits and risks for species can be complex.

https://www.quantamagazine.org/how-supergenes-fuel-evolution-despite-harmful-mutations-20221108/

Does vitamin D reduce COVID-19 severity?

A recent review posted to the Research Square* preprint server examined published studies for a consistent association between vitamin D levels and coronavirus disease 2019 (COVID-19) severity.

https://www.news-medical.net/news/20221108/Does-vitamin-D-reduce-COVID-19-severity.aspx

Laser that is thinner than a MATCH can burn away excess tissue to treat an enlarged prostate without damaging nearby healthy cells

https://www.dailymail.co.uk/health/article-11400469/Laser-thinner-MATCH-burn-away-excess-tissue-treat-enlarged-prostate.html

DNA-damaging molecules in the gut linked to colon cancer

The microbiome discovery could help save lives.

https://www.freethink.com/health/colorectal-cancer

Rejuvenated immune cells can improve clearance of toxic waste from brain

Findings in mice suggest new therapeutic approach to Alzheimer’s, other age-related diseases

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

https://www.nature.com/articles/s41380-022-01831-0

Study in mass spectrometry-based metabolomics approach and cytotoxic activity of methanolic extracts of sea cucumbers

https://aip.scitation.org/doi/abs/10.1063/5.0103213

Synergistic AntitumorEffectof Thymoquinone Combined with Resveratrol against Human Lung Cancer Cells Line

https://journals.ajsrp.com/index.php/jmps/article/view/5553/5290

Marine-Inspired Drugs and Biomaterials in the Perspective of Pancreatic Cancer Therapies

https://www.mdpi.com/1660-3397/20/11/689

NK cells and solid tumors: therapeutic potential and persisting obstacles

https://link.springer.com/article/10.1186/s12943-022-01672-z

Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

https://jitc.bmj.com/content/10/11/e005632

TCM plant DONG LING CAO – ORIDONIN: A REVIEW OF ITS SCOPE IN ANTICANCER THERAPY

https://www.researchgate.net/profile/Sanjay-Gaikwad-15/publication/364386912_ORIDONIN_A_REVIEW_OF_ITS_SCOPE_IN_ANTICANCER_THERAPY/links/6350fdec12cbac6a3edc70b5/ORIDONIN-A-REVIEW-OF-ITS-SCOPE-IN-ANTICANCER-THERAPY.pdf

NK cell therapy in relapsed refractory multiple myeloma

https://www.sciencedirect.com/science/article/abs/pii/S1521661622002492

Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects

https://journals.sagepub.com/doi/full/10.1177/1534735419889150

COVID-19 Vaccines: Proof of Lethality. Over One Thousand Scientific Studies

COVID-19 Vaccines: Proof of Lethality. Over One Thousand Scientific Studies

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927716/

Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics

https://www.mdpi.com/1422-0067/22/23/13044/htm

Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells

https://academic.oup.com/nar/article/50/19/10981/6777795

Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors

https://www.nature.com/articles/s41598-020-76351-4

Berberine inhibits pancreatic intraepithelial neoplasia by inhibiting glycolysis via the adenosine monophosphate -activated protein kinase pathway

https://www.sciencedirect.com/science/article/abs/pii/S0014299921008360

NK cell upraise in the dark world of cancer stem cells

https://cancerci.biomedcentral.com/articles/10.1186/s12935-021-02400-1

The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer

https://www.sciencedirect.com/science/article/pii/S0753332221013032

Thyme and oregano possess an anticancer compound that suppresses tumor development

Experimental treatment in Spain puts 18 cancer patients in complete remission

Barcelona’s Clínic Hospital announces hopeful results for people with multiple myeloma. Developed through the public system, the cost is lower than commercially available products

https://english.elpais.com/usa/2021-12-21/experimental-treatment-in-spain-puts-18-cancer-patients-in-complete-remission.html

Antidepressant fluvoxamine can keep COVID-19 patients out of the hospital

A 10-day course may work as an easy at-home treatment for early COVID-19, a clinical trial finds

https://www.asbmb.org/asbmb-today/science/120421/fluvoxamine-and-covid

Covid-19: The ivermectin story

https://www.riotimesonline.com/brazil-news/modern-day-censorship/covid-19-the-entire-ivermectin-story/

There’s a giant, mysterious gap in the omicron variant’s family tree

Scientists can’t yet explain the origin of the omicron variant — but all of their theories are troubling

https://www.salon.com/2021/12/21/theres-a-giant-mysterious-gap-in-the-omicron-variants-family-tree/

Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development

https://link.springer.com/article/10.1007/s40259-021-00495-6

The Original Antigenic Sin: COVID-19 Vaccination and Sub-Optimal Initial Immune Priming Deranges the Antibody- Cytotoxic T cell Immune Response

https://www.trialsitenews.com/a/the-original-antigenic-sin-covid-19-vaccination-and-sub-optimal-initial-immune-priming-deranges-the-antibody-cytotoxic-t-cell-immune-response

Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS

https://www.frontiersin.org/articles/10.3389/fimmu.2020.01120/full

“Original antigenic sin”: A potential threat beyond the development of booster vaccination against novel SARS-CoV-2 variants

https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/original-antigenic-sin-a-potential-threat-beyond-the-development-of-booster-vaccination-against-novel-sarscov2-variants/C8F4B9BE9E77EB566C71E98553579506?fbclid=IwAR3HzfenNv1Bw7fAj1iLskXYm4qmHlgwXWxNzTxfQmUQwVHMFn-ip9r1o-U

Is original antigenic sin starting to dominate covid?

https://boriquagato.substack.com/p/is-original-antigenic-sin-starting

Original Antigenic Sin is a Real and Very Serious Reason to Stop Vaccinating Everyone

Two papers discover that cross-reacting antibodies from common coronavirus infections can hinder effective antibody response to SARS-CoV-2

https://www.eugyppius.com/p/original-antigenic-sin-is-a-real

There’s something antigenic in denmark: boosters show negative vaccine efficacy for cases

https://boriquagato.substack.com/p/theres-something-antigenic-in-denmark

Targeting of Breast Cancer Stem Cells to improve the Treatment of Triple Negative Breast Cancer

https://www.tdx.cat/handle/10803/675875

Combination of niclosamide and current therapies to overcome resistance for cancer: New frontiers for an old drug

https://www.sciencedirect.com/science/article/pii/S0753332222011787

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

https://www.mdpi.com/2072-6694/14/14/3368

Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection

Niclosamide (NIC), effectively inhibits both inflammasome activation and SARS-CoV-2 replication.

https://www.science.org/doi/full/10.1126/sciadv.abo5400

Deciphering the Warburg effect: Redox is the key to tumor differentiation

https://aacrjournals.org/cancerres/article/82/12_Supplement/2180/699709

Repositioning an old antihelminthic agent of niclosamide in human disease and cancer

https://www.authorea.com/doi/full/10.22541/au.165397329.90665196

Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy

https://www.sciencedirect.com/science/article/abs/pii/S0142961222005208

Azithromycin as Potent Inhibitor of Cell Migration in Tumor Cell Line

http://jonuns.com/index.php/journal/article/view/1086

Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies

https://link.springer.com/article/10.1186/s13643-021-01858-4

Inhibition of PDK3 by artemisinin, a repurposed antimalarial drug in cancer therapy

https://www.sciencedirect.com/science/article/abs/pii/S0167732222004664

Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990469/

Benzimidazoles – Double Repositioning: Veterinary Antiparasitic to Human Anticancer

https://www.mdpi.com/1422-0067/23/8/4315/htm

The effect of flubendazole on microtubule polymerization and post-translational modifications

https://www.annalsofoncology.org/article/S0923-7534(22)04079-0/fulltext

Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer

https://www.nature.com/articles/s41419-022-04823-8

Cyclodextrin Dispersion of Mebendazole and Flubendazole Improves In Vitro Antiproliferative Activity

https://www.mdpi.com/2227-9717/9/12/2185

Flubendazole induces mitotic catastrophe and senescence in colon cancer cells in vitro

https://academic.oup.com/jpp/article/68/2/208/6128950

PD1 checkpoint inhibitorThe anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation

There are no clinically available PD-1/PD-L1 inhibitors for cancer. We found that flubendazole, an antihelmintic available without a prescription in Europe, is a novel small molecule pharmacologic inhibitor of PD-1.•

Flubendazole abrogates growth and metastasis of human melanoma grown as xenografts in mice.•

Flubendazole suppresses angiogenesis in human melanoma.•

Besides inhibiting PD-1, flubendazole inhibits phospho-(Tyr705) STAT3 in human melanoma cells and within treated tumors.•

Flubendazole also suppresses myeloid-derived suppressor cell (MDSC) accumulation within tumors.

https://www.sciencedirect.com/science/article/abs/pii/S0304383519303210

Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy

https://www.mdpi.com/1424-8247/14/4/372

People With Complete Paralysis Walk Again After Nerve Stimulation Breakthrough

Using a mix of electrical stimulation and intense physical therapy, nine people with chronic spinal injuries have had their ability to walk restored.

https://www.sciencealert.com/people-with-complete-paralysis-walk-again-after-nerve-stimulation-breakthrough

The neurons that restore walking after paralysis

https://www.nature.com/articles/s41586-022-05385-7

Electrical stimulation helps paralysed people walk again — and now we know why

Detailed gene-activity map could pave way for more precise treatments for many more people with spinal-cord injuries.

https://www.nature.com/articles/d41586-022-03605-8

Identification of the cells responsible for colon cancer relapse

Researchers report the discovery of the population of residual tumor cells responsible for the recurrence of colorectal cancer in other organs after removal of the primary tumor. The study shows that early immunotherapy, before surgery, can eliminate these cells before they have started to develop a metastasis, and thus prevent relapse of the disease. The work paves the way for the development of new therapeutic approaches and diagnostic tools to slow down the progression of the disease and improve its prognosis.

https://www.sciencedaily.com/releases/2022/11/221109151943.htm

The X chromosome is silenced in some male cancers

Cancer cells acquire genetic anomalies that allow them to grow and proliferate unchecked. Researchers have now found another difference between cancer cells and normal cells: the X chromosome, typically only inactivated in XX female cells, can be inactivated across different male-derived cancers.

https://www.sciencedaily.com/releases/2022/11/221109124352.htm

https://www.cell.com/cell-systems/fulltext/S2405-4712(22)00403-3

Copper a clue in the fight against cancer

For cancer cells to grow and spread around the human body, they need proteins that bind copper ions. New research about how cancer-related proteins bind the metal and how they interact with other proteins, opens up potential new drug targets in the fight against cancer.

https://phys.org/news/2022-11-copper-clue-cancer.html

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

https://aacrjournals.org/cancerres/article/80/19/4129/645520/Intratumoral-Copper-Modulates-PD-L1-Expression-and

Copper Toxicity and Chelation Therapy

Copper acts as a cofactor for many enzymes necessary for the redox reaction such as cytochrome c oxidase, ascorbic oxidase or superoxide dismutase. Copper is commonly used in the biological system for electron transport system [13,36]. Cu promotes oxidative damage in the conditions of increased Cu levels in the liver and brain. The best known disorder associated with Cu dyshomeostasis is Wilson’s disease, an autosomal recessive disorder linked to the Cu transporter expressed in hepatocytes. Cu toxicity has been linked with cardiovascular disease, atherosclerosis, diabetes, cancer progression and especially to neurological disorders. Copper can also induce oxidative stress by depleting glutathione levels [6,9,37,38]. D-Penicillamine has been extensively used in copper overload [39-42]. Trientine or tetrathiomolybdate has been increasingly recommended as the first-line treatment for neurologic Wilson disease [43-48] (Table 1).

X Chromosome Inactivation Surprisingly Found in Diverse Cancers in Men

Epigenetics: Are we in a new era of cancer research?

Epigenetics is a conceptually and practically challenging area of research. However, work over the past 5 years has suggested it could be behind many of the remaining questions we have about how cancers arise, proliferate, and reappear.

https://www.medicalnewstoday.com/articles/epigenetics-are-we-in-a-new-era-of-cancer-research

Focus on immune checkpoint PD-1/PD-L1 pathway: New advances of polyphenol phytochemicals in tumor immunotherapy

PD-1/PD-L1 pathway is a key pathway for tumor immune evasion.•

Polyphenolic compounds have immune checkpoint protein PD-L1 regulatory function.•

Polyphenols enhance the immunotherapeutic effect of anti-PD-1/PD-L1 antibodies.

https://www.sciencedirect.com/science/article/pii/S0753332222010071