A Cephalopod Has Passed a Cognitive Test Designed For Human Children
https://www.sciencealert.com/cuttlefish-can-pass-a-cognitive-test-designed-for-children
The mechanisms of action of ivermectin against SARS-CoV-2
https://www.nature.com/articles/s41429-021-00491-6
Researchers found an inexpensive repurposed drug called fluvoxamine can save the lives of COVID-19 patients and cut hospital admissions by up to 30%.
First Report of Horizontal Gene Transfer Between Plant and Animal
Whiteflies overcome a toxin in plants they eat through the use of the plant’s own genetic protection, likely ferried from plant to insect millions of years ago by a virus.
Horizontal gene transfer in the acquisition of novel traits by metazoans
https://royalsocietypublishing.org/doi/full/10.1098/rspb.2013.2450
Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus
https://elifesciences.org/articles/60176
Coronavirus can persist for months after traversing entire body
The Role of Bovine Leukemia Virus in Breast Cancer
As many as 37 percent of human breast cancer cases may be attributable to exposure to bovine leukemia virus.
https://nutritionfacts.org/video/the-role-of-bovine-leukemia-virus-in-breast-cancer/
Could Viagra Help Prevent Alzheimer’s?
https://www.medscape.com/viewarticle/964389
16. Sicherheitsbericht des PEI: Hepatitis nach der Impfung und der Schein vom „sicheren Boostern“
Han lab developing light-activated immune cell therapy for cancers
Research may lead to better, safer immunotherapy for next generation precision medicine
Cancer cells drain energy from immune cells
- Researchers found that cancer cells use straw-like nanotubes to siphon mitochondria from immune cells, essentially draining their energy.
- Inhibiting nanotube formation could make certain anticancer therapies more effective.
https://www.nih.gov/news-events/nih-research-matters/cancer-cells-drain-energy-immune-cells
A pandemic of the vaccinated or Ivermectin ignored?
Niclosamide–Ivermectin combination to have the best synergy score
Synergistic Anti-SARS-CoV-2 Activity of Repurposed Anti-Parasitic Drug Combinations
Niclosamide suppresses T‑cell acute lymphoblastic leukemia growth through activation of apoptosis and autophagy
https://www.spandidos-publications.com/10.3892/or.2021.8241
First-line treatment with immune checkpoint inhibitor rather than BRAF and MEK leads to improved survival
1. Starting treatment with nivolumab/ipilimumab rather than dabrafenib/trametinib resulted in an improvement in 2-year overall survival (72% vs 52%)
2. The incidence of adverse events grade 3 or higher was relatively similar across all arms, although the events themselves differed.
EBC-46 – Team makes rare, natural cancer-fighting compound in the lab
Researchers have figured out how to make a powerful cancer-fighting compound that is naturally only found in a single tree species from a small rainforest region of Northeastern Australia.
The compound, designated EBC-46 and technically called tigilanol tiglate, works by promoting a localized immune response against tumors. The response breaks apart the tumor’s blood vessels and ultimately kills its cancerous cells.
Team makes rare, natural cancer-fighting compound in the lab
Sugar molecules as a target in cancer therapy
Cancer cells use sugar molecules on their surface to disable attacks by the body’s immune system. Researchers now report on how this mechanism can be neutralized.
https://www.sciencedaily.com/releases/2022/11/221107103218.htm
Epstein-Barr Virus-Positive Primary Diffuse Large B-cell Lymphoma of the Colon in a Patient With Human Immunodeficiency Virus
Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress
https://www.mdpi.com/2218-273X/12/11/1600
Cell competition may explain cancer relapses, research suggests
https://www.utsouthwestern.edu/newsroom/articles/year-2022/november-cell-competition.html
Cancer Cells in Mice May Hitch a Ride with Bone-Healing Stem Cells
Researchers have long observed a connection between bone metastasis and remodeling, which might be due to a close connection between the two cell types.
Statins may prevent people from losing eyesight in later life
Scientists also found people prescribed diabetes drugs, such as insulin and anti-inflammatories, had lower risk of developing the condition
https://www.telegraph.co.uk/news/2022/11/08/statins-may-prevent-people-losing-eyesight-later-life/
Chemotherapy-induced complement signaling modulates immunosuppression and metastatic relapse in breast cancer
https://www.nature.com/articles/s41467-022-33598-x
Beer hops compounds could help protect against Alzheimer’s disease
https://phys.org/news/2022-11-beer-compounds-alzheimer-disease.html
Did a Famous Doctor’s COVID Shot Make His Cancer Worse?
Ivermectin induces cell cycle arrest and caspase-dependent apoptosis in human urothelial carcinoma cells
https://www.medsci.org/v19p1567.htm
Efficacy of ivermectin against colon cancer induced by dimethylhydrazine in male wistar rats
https://www.sciencedirect.com/science/article/pii/S1319016422001815
Ivermectin-induced cell death of cervical cancer cells in vitro a consequence of precipitate formation in culture media
https://www.sciencedirect.com/science/article/pii/S0041008X22002186
Ivermectin kills cancer cells via extensive changes in the endoplasmic reticulum structure
http://repository.ajou.ac.kr/handle/201003/21756
Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin
https://www.proquest.com/openview/0f4c85ef6965d95a823f9400043f865c/1
The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
Ivermectin as an inhibitor of cancer stem‑like cells
https://www.spandidos-publications.com/10.3892/mmr.2017.8231
Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway
https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1251-7
Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs
https://www.sciencedirect.com/science/article/abs/pii/S0960894X19302781
Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982461/
Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
https://www.nature.com/articles/s41523-021-00229-5
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
https://www.frontiersin.org/articles/10.3389/fphar.2021.717529/full
Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress
https://www.sciencedirect.com/science/article/abs/pii/S0006291X18302869
Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer
https://www.spandidos-publications.com/10.3892/ijmm.2021.5005
Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway
https://onlinelibrary.wiley.com/doi/full/10.1111/cpr.12543
Pyroptosis: A new frontier in cancer
https://www.sciencedirect.com/science/article/pii/S0753332219352175
Ivermectin induces autophagy-mediated cell death through the AKT/mTOR signaling pathway in glioma cells
Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630406/
Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting
https://link.springer.com/article/10.1007/s10787-021-00796-w
Ivermectin as a multifaceted drug in COVID-19: Current insights
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313054/
Comparative Risk of Myocarditis/Pericarditis Following Second Doses of BNT162b2 and mRNA-1273 Coronavirus Vaccines
https://www.sciencedirect.com/science/article/pii/S0735109722068243
How Supergenes Fuel Evolution Despite Harmful Mutations
Supergenes that lock inherited traits together are widespread in nature. Recent work shows that their blend of genetic benefits and risks for species can be complex.
https://www.quantamagazine.org/how-supergenes-fuel-evolution-despite-harmful-mutations-20221108/
Does vitamin D reduce COVID-19 severity?
A recent review posted to the Research Square* preprint server examined published studies for a consistent association between vitamin D levels and coronavirus disease 2019 (COVID-19) severity.
https://www.news-medical.net/news/20221108/Does-vitamin-D-reduce-COVID-19-severity.aspx
Laser that is thinner than a MATCH can burn away excess tissue to treat an enlarged prostate without damaging nearby healthy cells
DNA-damaging molecules in the gut linked to colon cancer
The microbiome discovery could help save lives.
https://www.freethink.com/health/colorectal-cancer
Rejuvenated immune cells can improve clearance of toxic waste from brain
Findings in mice suggest new therapeutic approach to Alzheimer’s, other age-related diseases
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
https://www.nature.com/articles/s41380-022-01831-0
Study in mass spectrometry-based metabolomics approach and cytotoxic activity of methanolic extracts of sea cucumbers
https://aip.scitation.org/doi/abs/10.1063/5.0103213
Synergistic AntitumorEffectof Thymoquinone Combined with Resveratrol against Human Lung Cancer Cells Line
https://journals.ajsrp.com/index.php/jmps/article/view/5553/5290
Marine-Inspired Drugs and Biomaterials in the Perspective of Pancreatic Cancer Therapies
https://www.mdpi.com/1660-3397/20/11/689
NK cells and solid tumors: therapeutic potential and persisting obstacles
https://link.springer.com/article/10.1186/s12943-022-01672-z
Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition
https://jitc.bmj.com/content/10/11/e005632
TCM plant DONG LING CAO – ORIDONIN: A REVIEW OF ITS SCOPE IN ANTICANCER THERAPY
NK cell therapy in relapsed refractory multiple myeloma
https://www.sciencedirect.com/science/article/abs/pii/S1521661622002492
Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects
https://journals.sagepub.com/doi/full/10.1177/1534735419889150
COVID-19 Vaccines: Proof of Lethality. Over One Thousand Scientific Studies
COVID-19 Vaccines: Proof of Lethality. Over One Thousand Scientific Studies
Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927716/
Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics
https://www.mdpi.com/1422-0067/22/23/13044/htm
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
https://academic.oup.com/nar/article/50/19/10981/6777795
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors
https://www.nature.com/articles/s41598-020-76351-4
Berberine inhibits pancreatic intraepithelial neoplasia by inhibiting glycolysis via the adenosine monophosphate -activated protein kinase pathway
https://www.sciencedirect.com/science/article/abs/pii/S0014299921008360
NK cell upraise in the dark world of cancer stem cells
https://cancerci.biomedcentral.com/articles/10.1186/s12935-021-02400-1
The importance of immune checkpoints in immune monitoring: A future paradigm shift in the treatment of cancer
https://www.sciencedirect.com/science/article/pii/S0753332221013032
Thyme and oregano possess an anticancer compound that suppresses tumor development
Experimental treatment in Spain puts 18 cancer patients in complete remission
Barcelona’s Clínic Hospital announces hopeful results for people with multiple myeloma. Developed through the public system, the cost is lower than commercially available products
Antidepressant fluvoxamine can keep COVID-19 patients out of the hospital
A 10-day course may work as an easy at-home treatment for early COVID-19, a clinical trial finds
https://www.asbmb.org/asbmb-today/science/120421/fluvoxamine-and-covid
Covid-19: The ivermectin story
There’s a giant, mysterious gap in the omicron variant’s family tree
Scientists can’t yet explain the origin of the omicron variant — but all of their theories are troubling
https://www.salon.com/2021/12/21/theres-a-giant-mysterious-gap-in-the-omicron-variants-family-tree/
Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development
https://link.springer.com/article/10.1007/s40259-021-00495-6
The Original Antigenic Sin: COVID-19 Vaccination and Sub-Optimal Initial Immune Priming Deranges the Antibody- Cytotoxic T cell Immune Response
Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS
https://www.frontiersin.org/articles/10.3389/fimmu.2020.01120/full
“Original antigenic sin”: A potential threat beyond the development of booster vaccination against novel SARS-CoV-2 variants
Is original antigenic sin starting to dominate covid?
https://boriquagato.substack.com/p/is-original-antigenic-sin-starting
Original Antigenic Sin is a Real and Very Serious Reason to Stop Vaccinating Everyone
Two papers discover that cross-reacting antibodies from common coronavirus infections can hinder effective antibody response to SARS-CoV-2
https://www.eugyppius.com/p/original-antigenic-sin-is-a-real
There’s something antigenic in denmark: boosters show negative vaccine efficacy for cases
https://boriquagato.substack.com/p/theres-something-antigenic-in-denmark
Targeting of Breast Cancer Stem Cells to improve the Treatment of Triple Negative Breast Cancer
https://www.tdx.cat/handle/10803/675875
Combination of niclosamide and current therapies to overcome resistance for cancer: New frontiers for an old drug
https://www.sciencedirect.com/science/article/pii/S0753332222011787
Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors
https://www.mdpi.com/2072-6694/14/14/3368
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection
Niclosamide (NIC), effectively inhibits both inflammasome activation and SARS-CoV-2 replication.
https://www.science.org/doi/full/10.1126/sciadv.abo5400
Deciphering the Warburg effect: Redox is the key to tumor differentiation
https://aacrjournals.org/cancerres/article/82/12_Supplement/2180/699709
Repositioning an old antihelminthic agent of niclosamide in human disease and cancer
https://www.authorea.com/doi/full/10.22541/au.165397329.90665196
Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy
https://www.sciencedirect.com/science/article/abs/pii/S0142961222005208
Azithromycin as Potent Inhibitor of Cell Migration in Tumor Cell Line
http://jonuns.com/index.php/journal/article/view/1086
Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
https://link.springer.com/article/10.1186/s13643-021-01858-4
Inhibition of PDK3 by artemisinin, a repurposed antimalarial drug in cancer therapy
https://www.sciencedirect.com/science/article/abs/pii/S0167732222004664
Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990469/
Benzimidazoles – Double Repositioning: Veterinary Antiparasitic to Human Anticancer
https://www.mdpi.com/1422-0067/23/8/4315/htm
The effect of flubendazole on microtubule polymerization and post-translational modifications
https://www.annalsofoncology.org/article/S0923-7534(22)04079-0/fulltext
Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer
https://www.nature.com/articles/s41419-022-04823-8
Cyclodextrin Dispersion of Mebendazole and Flubendazole Improves In Vitro Antiproliferative Activity
https://www.mdpi.com/2227-9717/9/12/2185
Flubendazole induces mitotic catastrophe and senescence in colon cancer cells in vitro
https://academic.oup.com/jpp/article/68/2/208/6128950
PD1 checkpoint inhibitor – The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation
There are no clinically available PD-1/PD-L1 inhibitors for cancer. We found that flubendazole, an antihelmintic available without a prescription in Europe, is a novel small molecule pharmacologic inhibitor of PD-1.•
Flubendazole abrogates growth and metastasis of human melanoma grown as xenografts in mice.•
Flubendazole suppresses angiogenesis in human melanoma.•
Besides inhibiting PD-1, flubendazole inhibits phospho-(Tyr705) STAT3 in human melanoma cells and within treated tumors.•
Flubendazole also suppresses myeloid-derived suppressor cell (MDSC) accumulation within tumors.
https://www.sciencedirect.com/science/article/abs/pii/S0304383519303210
Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy
https://www.mdpi.com/1424-8247/14/4/372
People With Complete Paralysis Walk Again After Nerve Stimulation Breakthrough
Using a mix of electrical stimulation and intense physical therapy, nine people with chronic spinal injuries have had their ability to walk restored.
The neurons that restore walking after paralysis
https://www.nature.com/articles/s41586-022-05385-7
Electrical stimulation helps paralysed people walk again — and now we know why
Detailed gene-activity map could pave way for more precise treatments for many more people with spinal-cord injuries.
https://www.nature.com/articles/d41586-022-03605-8
Identification of the cells responsible for colon cancer relapse
Researchers report the discovery of the population of residual tumor cells responsible for the recurrence of colorectal cancer in other organs after removal of the primary tumor. The study shows that early immunotherapy, before surgery, can eliminate these cells before they have started to develop a metastasis, and thus prevent relapse of the disease. The work paves the way for the development of new therapeutic approaches and diagnostic tools to slow down the progression of the disease and improve its prognosis.
https://www.sciencedaily.com/releases/2022/11/221109151943.htm
The X chromosome is silenced in some male cancers
Cancer cells acquire genetic anomalies that allow them to grow and proliferate unchecked. Researchers have now found another difference between cancer cells and normal cells: the X chromosome, typically only inactivated in XX female cells, can be inactivated across different male-derived cancers.
https://www.sciencedaily.com/releases/2022/11/221109124352.htm
https://www.cell.com/cell-systems/fulltext/S2405-4712(22)00403-3
Copper a clue in the fight against cancer
For cancer cells to grow and spread around the human body, they need proteins that bind copper ions. New research about how cancer-related proteins bind the metal and how they interact with other proteins, opens up potential new drug targets in the fight against cancer.
https://phys.org/news/2022-11-copper-clue-cancer.html
Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Copper Toxicity and Chelation Therapy
Copper acts as a cofactor for many enzymes necessary for the redox reaction such as cytochrome c oxidase, ascorbic oxidase or superoxide dismutase. Copper is commonly used in the biological system for electron transport system [13,36]. Cu promotes oxidative damage in the conditions of increased Cu levels in the liver and brain. The best known disorder associated with Cu dyshomeostasis is Wilson’s disease, an autosomal recessive disorder linked to the Cu transporter expressed in hepatocytes. Cu toxicity has been linked with cardiovascular disease, atherosclerosis, diabetes, cancer progression and especially to neurological disorders. Copper can also induce oxidative stress by depleting glutathione levels [6,9,37,38]. D-Penicillamine has been extensively used in copper overload [39-42]. Trientine or tetrathiomolybdate has been increasingly recommended as the first-line treatment for neurologic Wilson disease [43-48] (Table 1).
X Chromosome Inactivation Surprisingly Found in Diverse Cancers in Men
Epigenetics: Are we in a new era of cancer research?
Epigenetics is a conceptually and practically challenging area of research. However, work over the past 5 years has suggested it could be behind many of the remaining questions we have about how cancers arise, proliferate, and reappear.
https://www.medicalnewstoday.com/articles/epigenetics-are-we-in-a-new-era-of-cancer-research
Focus on immune checkpoint PD-1/PD-L1 pathway: New advances of polyphenol phytochemicals in tumor immunotherapy
PD-1/PD-L1 pathway is a key pathway for tumor immune evasion.•
Polyphenolic compounds have immune checkpoint protein PD-L1 regulatory function.•
Polyphenols enhance the immunotherapeutic effect of anti-PD-1/PD-L1 antibodies.
https://www.sciencedirect.com/science/article/pii/S0753332222010071