Vitamin B3 – Popular dietary supplement linked to cancer risk, brain metastasis
While previous studies have linked commercial dietary supplements like nicotinamide riboside (NR), a form of vitamin B3, to benefits related to cardiovascular, metabolic and neurological health, new research from the University of Missouri has found NR could actually increase the risk of serious disease, including developing cancer.
Benzodiazipines – Taking This Common Medication Long-Term Could Lead to Alzheimer’s
A “key role is played by immune cells of the brain known as microglia.” Benzodiazepines “bind to a specific protein, the translocator protein (TSPO), on the surface of cell organelles of the microglia,” the site says. “This binding activates the microglia, which then degrade and recycle synapses—that is, the connections between nerve cells.”
https://bestlifeonline.com/benzodiazepines-spike-dementia-risk-news/
Everything Jeff Bridges Has Said About His Battle With Lymphoma: ‘COVID Made My Cancer Look Like Nothing
https://www.yahoo.com/entertainment/everything-jeff-bridges-said-battle-142137627.html
Breast cancer cells might have ‘electrical language
https://interestingengineering.com/health/breast-cancer-cells-electrical-language
An exercise-induced metabolic shield in distant organs blocks cancer progression and metastatic dissemination
https://europepmc.org/article/med/36084256
Green Tea and Resveratrol Reduce Alzheimer’s Plaques
Unregulated ‘innovation’: India’s medicine problem
If India is the pharmacy of the world, it’s not doing a good job of providing safe products. A large number of children in the Gambia and Indonesia have recently died after ingesting cough syrup made in India. And in 2019, 11 children in India’s Jammu region died the same way. The cough medicine contained diethylene glycol, an industrial solvent.
https://theconversation.com/unregulated-innovation-indias-medicine-problem-193630
How high blood sugar REALLY causes type 2 diabetes: Chemicals produced when glucose is broken down are to blame, study finds
- Oxford University researchers looked into how type 2 diabetes progresses
- Found chemicals released when sugar is broken down cause patients’ decline
- Discovery could lead to new treatments that could slow the condition’s effects
Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
https://www.nature.com/articles/s41467-022-30240-8
Protein Pilfered from Cancer Cells Thwarts Immune Attack
New research in mice reveals why natural killer cells, normally effective at hunting cancer, are sometimes stopped in their tracks.
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
https://academic.oup.com/nar/article/50/19/10981/6777795
Probiotics Are Becoming a New Front in Fighting Cancer
These microbial residents of the gut play a deciding role in many disease pathologies, research suggests
Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590174/
Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts
https://www.sciencedirect.com/science/article/pii/S2666379122000416
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion
https://pubs.acs.org/doi/10.1021/acschembio.2c00004
Radical lupus treatment uses CAR T-cell therapy developed for cancer
Five people with the autoimmune condition lupus are now in remission after receiving a version of CAR-T therapy, which was originally developed for cancer
Repurposed Drug Can Target Cancer Cells’ Shield Against Immune System
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy
https://jitc.bmj.com/content/10/8/e004660
Letrozole could be repurposed for the treatment of liver fibrosis
https://medicalxpress.com/news/2022-11-letrozole-repurposed-treatment-liver-fibrosis.html
Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials
https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02599-4
Repurposing radiotherapy drugs could give immunotherapy a boost
Study reveals how to activate natural killer cells to protect against cancer and other diseases
- Collagens and elastin in the extracellular matrix, which forms a scaffold to support organs, cause the immune system’s natural killer cells to switch off their “killer” function.
- The hypertension drug losartan can cause a previously resistant melanoma to become sensitive to natural killer cells by blocking collagen deposition in the tumor.
Losartan could improve ovarian cancer treatment
Researchers have found that losartan could be beneficial for those undergoing cancer treatment as it may enhance its effectiveness…
https://www.europeanpharmaceuticalreview.com/news/83034/losartan-ovarian-cancer/
Competition between immune cells could explain why some immunotherapy drugs fail
Immune cells may become ‘exhausted’ during immunotherapy
Celecoxib – Common anti-inflammatory drug could boost cancer immunotherapy
An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078164/
Cannabidiol (CBD) – kann die Freisetzung von Exosomen blockieren. CBD kann die Freisetzung
von Exosomen bei 5 µM um 50 % blockieren und die Freisetzung von Exosomen aus
Krebszelllinien (z. B. Prostata-, Brust-, Leberkrebs, Glioblastom) selektiv hemmen.
Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768245/
Metabolic Anti-Cancer Effects of Melatonin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234897/
Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185415/
The synthesis and anticancer effects of a range of natural and unnatural hop β-acids on breast cancer cells
https://www.sciencedirect.com/science/article/abs/pii/S1874390011001753
Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells
https://link.springer.com/article/10.1007/s10495-008-0250-5
Discovery of Natural Product Ellagic Acid as a Potent CD73 and CD39 Dual Inhibitor
Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor
https://pubmed.ncbi.nlm.nih.gov/26296573/
Ordered and deterministic cancer genome evolution after p53 loss
https://www.nature.com/articles/s41586-022-05082-5
Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369426/
Hitting the Bull’s-Eye in Metastatic Cancers—NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death
https://www.mdpi.com/1424-8247/8/1/62/htm
High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity
https://www.frontiersin.org/articles/10.3389/fimmu.2019.01141/full
Phytochemicals, withaferin A and carnosol, overcome pancreatic cancer stem cells as c-Met inhibitors
https://www.sciencedirect.com/science/article/abs/pii/S0753332218330701
Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity
https://pubmed.ncbi.nlm.nih.gov/20539971/
Sulforaphane induces colorectal cancer cell proliferation through Nrf2 activation in a p53-dependent manner
https://applbiolchem.springeropen.com/articles/10.1186/s13765-020-00578-y
Krill oil extract suppresses cell growth and induces apoptosis of human colorectal cancer cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004275/
Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.32022
Brustkrebs erwacht im Schlaf
Coenzyme Q10 and Immune Function
https://www.mdpi.com/2076-3921/10/5/759/htm
Role of coenzymes in cancer metabolism
https://www.sciencedirect.com/science/article/pii/S1084952119300709
Moscatilin Suppresses the Breast Cancer Both In Vitro and In Vivo by Inhibiting HDAC3
https://journals.sagepub.com/doi/full/10.1177/15593258211001251
NAC – Popular antioxidant seems to spread skin cancer cells in mouse research
https://medicalxpress.com/news/2015-10-popular-antioxidant-skin-cancer-cells.html
NACA – Antioxidant may prevent, even cure, cataracts and other degenerative eye disorders
https://medicalxpress.com/news/2012-09-antioxidant-cataracts-degenerative-eye-disorders.html
Discovery shows how mucus build-up, not infections, triggers cystic fibrosis lung damage
https://medicalxpress.com/news/2019-04-discovery-mucus-build-up-infections-triggers.html
N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease
https://www.sciencedirect.com/science/article/abs/pii/S1096719218300416
Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331529/
The anti-metastatic effect of baicalein on colorectal cancer
https://www.spandidos-publications.com/10.3892/or.2017.5437
Baicalein suppresses the proliferation and invasiveness of colorectal cancer cells by inhibiting Snail‑induced epithelial‑mesenchymal transition
https://www.spandidos-publications.com/mmr/21/6/2544
Baicalin triggers apoptosis, inhibits migration, and enhances anti-tumor immunity in colorectal cancer via TLR4/NF-κB signaling pathway
https://onlinelibrary.wiley.com/doi/full/10.1111/jfbc.13703
Krebs: Was bedeuten die Kürzel im Arztbrief
https://www.gesundheitsinformation.de/krebs-was-bedeuten-die-kuerzel-im-arztbrief.html
Bergapten induces metabolic reprogramming in breast cancer cells
https://www.spandidos-publications.com/10.3892/or.2015.4327
Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism
https://www.sciencedirect.com/science/article/pii/S0005272818300616
Histamine in cancer immunology and immunotherapy. Current status and new perspectives
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1002/prp2.778
Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
https://www.cell.com/cell/fulltext/S0092-8674(21)01561-0
An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress
https://cancerci.biomedcentral.com/articles/10.1186/s12935-021-01892-1
Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate
https://www.spandidos-publications.com/ijo/35/1/149
Artesunate shows potent anti-tumor activity in B-cell lymphoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819282/
Tumour heterogeneity and resistance to cancer therapies
https://www.nature.com/articles/nrclinonc.2017.166
Repurposing Artemisinin and its Derivatives as Anticancer Drugs
https://www.frontiersin.org/articles/10.3389/fphar.2021.828856/full
Combination of Glucan, Resveratrol and Vitamin C Demonstrates Strong Anti-tumor Potential
https://ar.iiarjournals.org/content/32/1/81.long
Eggplant Extracts Kill Active and Dormant Cancer Cells
Fructose contributes to the Warburg effect for cancer growth
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-020-00222-9
PEA – Palmitoylethanolamide Reduces Colon Cancer Cell Proliferation and Migration, Influences Tumor Cell Cycle and Exerts In Vivo Chemopreventive Effects
https://www.mdpi.com/2072-6694/13/8/1923/htm
The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605069/
Tumor lysis syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411564/
Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3
https://www.frontiersin.org/articles/10.3389/fonc.2021.684316/full
Fisetin: An anticancer perspective
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.1872
Spermidine reduces cancer-related mortality in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333461/
Cimetidine as an anti-cancer agent
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268104/
Pyrvinium For The Treatment of Cancer
https://patents.google.com/patent/US20090099062A1/en
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
https://link.springer.com/article/10.1007/s11095-008-9661-9
Role of Glutathione in Cancer Progression and Chemoresistance
https://www.hindawi.com/journals/omcl/2013/972913/
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level
https://www.sciencedirect.com/science/article/pii/S0009279720301381
Targeting at cancer energy metabolism and lipid droplet formation as new treatment strategies for epigallocatechin-3-gallate (EGCG) in colorectal cancer cells
EGCG inhibits viability of colorectal cancer (CRC) cells via AMPK activation.•
EGCG inhibits fatty acid de novo synthesis in CRC cells via AMPK activation.•
EGCG inhibits lipid droplet formation in CRC cells via AMPK activation.•
EGCG inhibits energy metabolism (mitochondrial oxidation/glycolysis) in CRC cells.
https://www.sciencedirect.com/science/article/pii/S175646462100219X
ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma
https://www.mdpi.com/2072-6694/12/9/2477/htm
Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30382-2
Gadolinium-Vergiftung – Diese Symptome können nach einer MRT-Untersuchung auftreten
The Case of PDE5 Inhibitor Sildenafil
https://www.frontiersin.org/articles/10.3389/fonc.2021.627229/full
Hexokinase II: Cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
https://www.nature.com/articles/1209603
Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281670/
Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
https://cancerci.biomedcentral.com/articles/10.1186/s12935-021-01906-y
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters.
https://europepmc.org/article/med/26099350
Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis
https://www.tandfonline.com/doi/abs/10.1080/01480545.2019.1573825
This drug could reduce heart disease, fatty liver, obesity
Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective
https://www.frontiersin.org/articles/10.3389/fonc.2020.01401/full
Assessment of the anti-genotoxic, anti-proliferative, and anti-metastatic potential of crude watercress extract in human colon cancer cells
https://www.tandfonline.com/doi/abs/10.1207/s15327914nc5502_15
An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology
https://www.frontiersin.org/articles/10.3389/fphar.2019.00857/full
Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs
https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0876-0
Repositioning of Antiparasitic Drugs for Tumor Treatment
https://www.frontiersin.org/articles/10.3389/fonc.2021.670804/full
Progesterone and Glucocorticoid Receptor Modulator Mifepristone (RU-486) as Treatment for Advanced Cancers
https://www.intechopen.com/chapters/73134
Forscher entdecken Schalter für Immunsystem
https://www.mdr.de/wissen/mensch-alltag/forscher-entdecken-schalter-fuer-glueckshormon-100.html
ROS in cancer therapy: the bright side of the moon
https://www.nature.com/articles/s12276-020-0384-2
Andrographolide is an Alternative Treatment to Overcome Resistance in ER-Positive Breast Cancer via Cholesterol Biosynthesis Pathway.
https://europepmc.org/article/PMC/6839656
Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520007/
Combining vitamin C with antibiotics destroys cancer stem cells
https://www.medicalnewstoday.com/articles/317902
Cannabinoide – Immunmodulation und Tumortherapie
https://www.pharmazeutische-zeitung.de/inhalt-06-2005/titel-06-2005/
Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity
https://academic.oup.com/brain/article/145/9/3288/6650959
Fungi grow inside cancerous tumors, scientists discover
https://www.livescience.com/fungi-found-in-tumors
Tumor Angiogenesis as a Target for Dietary Cancer Prevention
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184418/
Moderne Betrachtungsweisen des Laktats: Laktat ein überschätztes und zugleich unterschätztes Molekül
Brown-fat-mediated tumour suppression by cold-altered global metabolism
https://www.nature.com/articles/s41586-022-05030-3
Overcoming cancer therapeutic bottleneck by drug repurposing
https://www.nature.com/articles/s41392-020-00213-8
Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067498/
Copper a clue in the fight against cancer
https://phys.org/news/2022-11-copper-clue-cancer.html
Leprosy bacteria hold anti-ageing secrets and can regenerate organs
Researchers discover the mechanism for heart complications from immune checkpoint inhibitors
Bacteria in tumors may promote cancer
Microbial interlopers may set off chain reaction that can suppress immune system and lead to metastasis
https://www.science.org/content/article/bacteria-tumors-may-promote-cancer
Ferroptosis of tumour neutrophils causes immune suppression in cancer
https://www.nature.com/articles/s41586-022-05443-0
Researchers develop promising new cancer therapy
Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system’s T cells to attack tumor cells. Their introduction a decade ago marked a major advance in cancer therapy, but only 10% to 30% of treated patients experience long-term improvement. New findings could now bolster the effectiveness of immune-checkpoint therapy.
https://www.sciencedaily.com/releases/2022/11/221116085957.htm
Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell–mediated antitumor immunity
https://www.jci.org/articles/view/163620
Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus
Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
https://www.nature.com/articles/s41586-022-05435-0
First-In-Class Immune Checkpoint Therapy Unlocks NK Cell Attack on Tumors
Seagrass in Mandapam can fight cancer