Articles and science papers (unsorted part 2.7)

Vitamin B3 – Popular dietary supplement linked to cancer risk, brain metastasis

While previous studies have linked commercial dietary supplements like nicotinamide riboside (NR), a form of vitamin B3, to benefits related to cardiovascular, metabolic and neurological health, new research from the University of Missouri has found NR could actually increase the risk of serious disease, including developing cancer.

Benzodiazipines – Taking This Common Medication Long-Term Could Lead to Alzheimer’s

A “key role is played by immune cells of the brain known as microglia.” Benzodiazepines “bind to a specific protein, the translocator protein (TSPO), on the surface of cell organelles of the microglia,” the site says. “This binding activates the microglia, which then degrade and recycle synapses—that is, the connections between nerve cells.”

Everything Jeff Bridges Has Said About His Battle With Lymphoma: ‘COVID Made My Cancer Look Like Nothing

Breast cancer cells might have ‘electrical language

An exercise-induced metabolic shield in distant organs blocks cancer progression and metastatic dissemination

Green Tea and Resveratrol Reduce Alzheimer’s Plaques

Unregulated ‘innovation’: India’s medicine problem

If India is the pharmacy of the world, it’s not doing a good job of providing safe products. A large number of children in the Gambia and Indonesia have recently died after ingesting cough syrup made in India. And in 2019, 11 children in India’s Jammu region died the same way. The cough medicine contained diethylene glycol, an industrial solvent.

How high blood sugar REALLY causes type 2 diabetes: Chemicals produced when glucose is broken down are to blame, study finds

  • Oxford University researchers looked into how type 2 diabetes progresses 
  • Found chemicals released when sugar is broken down cause patients’ decline
  • Discovery could lead to new treatments that could slow the condition’s effects

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

Protein Pilfered from Cancer Cells Thwarts Immune Attack

New research in mice reveals why natural killer cells, normally effective at hunting cancer, are sometimes stopped in their tracks.

Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells

Probiotics Are Becoming a New Front in Fighting Cancer

These microbial residents of the gut play a deciding role in many disease pathologies, research suggests

Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma

Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

Radical lupus treatment uses CAR T-cell therapy developed for cancer

Five people with the autoimmune condition lupus are now in remission after receiving a version of CAR-T therapy, which was originally developed for cancer

Repurposed Drug Can Target Cancer Cells’ Shield Against Immune System

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy

Letrozole could be repurposed for the treatment of liver fibrosis

Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials

Repurposing radiotherapy drugs could give immunotherapy a boost

Study reveals how to activate natural killer cells to protect against cancer and other diseases

  • Collagens and elastin in the extracellular matrix, which forms a scaffold to support organs, cause the immune system’s natural killer cells to switch off their “killer” function.
  • The hypertension drug losartan can cause a previously resistant melanoma to become sensitive to natural killer cells by blocking collagen deposition in the tumor.

Losartan could improve ovarian cancer treatment

Researchers have found that losartan could be beneficial for those undergoing cancer treatment as it may enhance its effectiveness…

Competition between immune cells could explain why some immunotherapy drugs fail

Immune cells may become ‘exhausted’ during immunotherapy

Celecoxib – Common anti-inflammatory drug could boost cancer immunotherapy

An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Cannabidiol (CBD) – kann die Freisetzung von Exosomen blockieren. CBD kann die Freisetzung
von Exosomen bei 5 µM um 50 % blockieren und die Freisetzung von Exosomen aus
Krebszelllinien (z. B. Prostata-, Brust-, Leberkrebs, Glioblastom) selektiv hemmen

Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression

Metabolic Anti-Cancer Effects of Melatonin

Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner

The synthesis and anticancer effects of a range of natural and unnatural hop β-acids on breast cancer cells

Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells

Discovery of Natural Product Ellagic Acid as a Potent CD73 and CD39 Dual Inhibitor

Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor

Ordered and deterministic cancer genome evolution after p53 loss

Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders

Hitting the Bull’s-Eye in Metastatic Cancers—NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death

High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity

Phytochemicals, withaferin A and carnosol, overcome pancreatic cancer stem cells as c-Met inhibitors

Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity

Sulforaphane induces colorectal cancer cell proliferation through Nrf2 activation in a p53-dependent manner

Krill oil extract suppresses cell growth and induces apoptosis of human colorectal cancer cells

Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone

Brustkrebs erwacht im Schlaf

Coenzyme Q10 and Immune Function

Role of coenzymes in cancer metabolism

Moscatilin Suppresses the Breast Cancer Both In Vitro and In Vivo by Inhibiting HDAC3

NAC – Popular antioxidant seems to spread skin cancer cells in mouse research

NACA – Antioxidant may prevent, even cure, cataracts and other degenerative eye disorders

Discovery shows how mucus build-up, not infections, triggers cystic fibrosis lung damage

N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease

Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders

The anti-metastatic effect of baicalein on colorectal cancer

Baicalein suppresses the proliferation and invasiveness of colorectal cancer cells by inhibiting Snail‑induced epithelial‑mesenchymal transition

Baicalin triggers apoptosis, inhibits migration, and enhances anti-tumor immunity in colorectal cancer via TLR4/NF-κB signaling pathway

Krebs: Was bedeuten die Kürzel im Arztbrief

Bergapten induces metabolic reprogramming in breast cancer cells

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism

Histamine in cancer immunology and immunotherapy. Current status and new perspectives

Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress

Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate

Artesunate shows potent anti-tumor activity in B-cell lymphoma

Tumour heterogeneity and resistance to cancer therapies

Repurposing Artemisinin and its Derivatives as Anticancer Drugs

Combination of Glucan, Resveratrol and Vitamin C Demonstrates Strong Anti-tumor Potential

Eggplant Extracts Kill Active and Dormant Cancer Cells

Fructose contributes to the Warburg effect for cancer growth

PEA – Palmitoylethanolamide Reduces Colon Cancer Cell Proliferation and Migration, Influences Tumor Cell Cycle and Exerts In Vivo Chemopreventive Effects

The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

Tumor lysis syndrome

Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3

Fisetin: An anticancer perspective

Spermidine reduces cancer-related mortality in humans

Cimetidine as an anti-cancer agent

Pyrvinium For The Treatment of Cancer

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

Role of Glutathione in Cancer Progression and Chemoresistance

Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level

Targeting at cancer energy metabolism and lipid droplet formation as new treatment strategies for epigallocatechin-3-gallate (EGCG) in colorectal cancer cells

EGCG inhibits viability of colorectal cancer (CRC) cells via AMPK activation.•

EGCG inhibits fatty acid de novo synthesis in CRC cells via AMPK activation.•

EGCG inhibits lipid droplet formation in CRC cells via AMPK activation.•

EGCG inhibits energy metabolism (mitochondrial oxidation/glycolysis) in CRC cells.

ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma

Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

Gadolinium-Vergiftung – Diese Symptome können nach einer MRT-Untersuchung auftreten

The Case of PDE5 Inhibitor Sildenafil

Hexokinase II: Cancer’s double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance

Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters.

Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis

This drug could reduce heart disease, fatty liver, obesity

Intracellular pH Regulates Cancer and Stem Cell Behaviors: A Protein Dynamics Perspective

Assessment of the anti-genotoxic, anti-proliferative, and anti-metastatic potential of crude watercress extract in human colon cancer cells

An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Repositioning of Antiparasitic Drugs for Tumor Treatment

Progesterone and Glucocorticoid Receptor Modulator Mifepristone (RU-486) as Treatment for Advanced Cancers

Forscher entdecken Schalter für Immunsystem

ROS in cancer therapy: the bright side of the moon

Andrographolide is an Alternative Treatment to Overcome Resistance in ER-Positive Breast Cancer via Cholesterol Biosynthesis Pathway.

Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)

Combining vitamin C with antibiotics destroys cancer stem cells

Cannabinoide Immunmodulation und Tumortherapie

Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity

Fungi grow inside cancerous tumors, scientists discover

Tumor Angiogenesis as a Target for Dietary Cancer Prevention

Moderne Betrachtungsweisen des Laktats: Laktat ein überschätztes und zugleich unterschätztes Molekül

Brown-fat-mediated tumour suppression by cold-altered global metabolism

Overcoming cancer therapeutic bottleneck by drug repurposing

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy

Copper a clue in the fight against cancer

Leprosy bacteria hold anti-ageing secrets and can regenerate organs

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Bacteria in tumors may promote cancer

Microbial interlopers may set off chain reaction that can suppress immune system and lead to metastasis

Ferroptosis of tumour neutrophils causes immune suppression in cancer

Researchers develop promising new cancer therapy

Immune checkpoint inhibitors such as Keytruda and Opdivo work by unleashing the immune system’s T cells to attack tumor cells. Their introduction a decade ago marked a major advance in cancer therapy, but only 10% to 30% of treated patients experience long-term improvement. New findings could now bolster the effectiveness of immune-checkpoint therapy.

Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell–mediated antitumor immunity

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer

First-In-Class Immune Checkpoint Therapy Unlocks NK Cell Attack on Tumors

Seagrass in Mandapam can fight cancer