Articles and science papers (unsorted part5.1)

Modulating the tumor microenvironment improves antitumor effect of anti-PD-L1 mAb in breast cancer

Addition of losartan to FOLFORINOX and chemoradiation downregulates pro-invasion and immunosuppression-associated genes in locally advanced pancreatic cancer

Effects of losartan and vitamin D on outcomes in metastatic pancreatic adenocarcinoma

Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+ Cancer Cells in Locally Advanced Pancreatic Cancer

Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?

‘Dead zone’ within tumor promotes cancer spread, helped by a protein secreted by cancer cells

Lancet study reveals natural immunity is just as effective as COVID vaccine

Lab Leak Most Likely Origin of Covid-19 Pandemic, Energy Department Now Says
U.S. agency’s revised assessment is based on new intelligence

Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells

Intermittent fasting could increase risk of cancer, research finds
The findings could lead to a better understanding of how chronic fasting may affect the body in the long term

Meet the $10,000 Nvidia chip powering the race for A.I.

Luteolin – Potential of bioactive compound of Cyperus rotundus L. rhizome extract as inhibitor of PD-L1/PD-1 interaction

Icariside II potentiates the anti-PD-1 antitumor effect by reducing chemotactic infiltration of myeloid-derived suppressor cells into the tumor microenvironment via ROS-mediated inactivation of the SRC/ERK/STAT3 signaling pathways

Inflammation is culprit behind long COVID, study suggests

Murine research indicates that the S1 protein is gatekeeper for how the SARS-CoV-2 virus crosses the blood-brain barrier.

Ivermectin – Doctors Bristle At New FDA Authority To Ban Off-Label Uses For Drugs

Comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines

Incident autoimmune diseases in association with a SARS-CoV-2 infection

How can the size of Universe be bigger than its age?

How is the Universe so big, and why does its size seem to be bigger than its age?

The scale of the entire Universe versus JWST’s views

The glorious sights that JWST keeps revealing are less than a millionth of the whole Universe. Just imagine what else is out there.

Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity

In Massive Galactic Discovery, Webb Spots Super Old Galaxies That Shouldn’t Exist

In Massive Galactic Discovery, Webb Spots Super Old Galaxies That Shouldn’t Exist

Florida Surgeon General Warns Life-Threatening VAERS Reports Up 4,400 Percent Since COVID-19 Vaccine Rollout

Novavax COVID-19 Vaccine Associated With Heart Inflammation

Role of Glutathione in Cancer: From Mechanisms to Therapies

Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Biological mechanisms underpinning the development of Long COVID

Cytotoxic Activity, Anti-Migration and In Silico Study of Black Ginger (Kaempferia parviflora) Extract against Breast Cancer Cell

Recovery of the Sensitivity to Anti-PD-1 Antibody by Celecoxib in Lung Cancer

Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion

Targeting Cancer Stem Cells as the Key Driver of Carcinogenesis and Therapeutic Resistance

Breast cancer prevention with liquiritigenin from licorice

Endothelial dysfunction and angiogenesis: what is missing from COVID-19 and cannabidiol story?

PD-1 blockade following isolated limb perfusion with vaccinia virus prevents local and distant relapse of soft-tissue sarcoma

How T cells could fight many coronaviruses at once
LJI researchers work to head off future pandemics by uncovering key similarities between SARS-CoV-2 and common cold coronaviruses

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

Fish evolution takes place in decades – not millions of years

Geneticists discover hidden ‘whole genome duplication’ that may explain why some species survived mass extinctions

Study examines how DNA damage is repaired by antioxidant enzymes

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

Atlantic hurricane season 2023: El Niño and extreme Atlantic Ocean heat are about to clash

Essential process for SARS-CoV-2 viral replication visualized

Fungal–Bacterial Co-Infections and Super-Infections among Hospitalized COVID-19 Patients

Nvidia building one of the world’s fastest generative AI supercomputers in Israel
The Israel-1 supercomputer was developed in Israel over the past 18 months at a cost of hundreds of millions of dollars

Gene Elimination in Tregs Triggers Lifelong Anticancer Response in Mice

Pentoxifylline changes the balance of immune cell population in breast tumor-infiltrating lymphocytes

Immunotherapy: A promising novel endometriosis therapy

NF-κB in control of regulatory T cell development, identity, and function

Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance

Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach

NF-κB in the New Era of Cancer Therapy

Treg programming and therapeutic reprogramming in cancer

NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer

The reversal of aging begins in your gut: New study reveals promising findings

Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer

RNA’s ‘joints’ play key role in our gene expression, scientists find

The Universe violates the perfect cosmological principle

Scientists find that fish can recognize themselves in photos – study
Humans readily distinguish between photographs of both familiar – including the self – and unknown people by referring to mental images of faces. But what about fish?

Extracts From Two Wild Plants Inhibit COVID-19 Virus

Two common wild plants contain extracts that inhibit the ability of the virus that causes COVID-19 to infect living cells

Tall goldenrod and eagle fern. Both plant species are native to North America and are known for traditional medicinal uses by Native Americans.

How do we know the timeline of our Universe?

From the earliest stages of the hot Big Bang (and even before) to our dark energy-dominated present, how and when did the Universe grow up?

An Unintended Consequence of Antidepressant Use May be Antibiotic Resistance

Discovery of T-cells that protect against deadly pneumococcal disease

How immortal jellyfish turn back time

New treatment approach for prostate cancer could stop resistance in its tracks

Tricaprin – “Remarkable” Results – Scientists Discover That a Dietary Supplement Could Fix a Broken Heart

“Remarkable” Results – Scientists Discover That a Dietary Supplement Could Fix a Broken Heart

Intermittent fasting spurs proliferation of liver cells in lab mice, study finds

Team identifies a nutrient that cancer cells crave

Arginine is an amino acid naturally produced by our bodies and plentiful in the fish, meat, and nuts that we eat. But as recent research in Science Advances reveals, arginine is an essential nutrient for cancer cells too. And starving them of it could potentially render tumors more vulnerable to the body’s natural immune response.

Some cancer cells grow stronger after chemo. Research hints at how to kill them

Stopping the cancer cells that thrive on chemotherapy – research into how pancreatic tumors adapt to stress could lead to a new treatment approach

How Parkinson’s Disease Affects the Endocannabinoid System

Obesity-Associated Neurodegeneration Pattern Mimics Alzheimer’s Disease

Repurposing Ponatinib as a PD-L1 Inhibitor Revealed by Drug Repurposing Screening and Validation by In Vitro and In Vivo Experiments

Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions

Effect of metformin on outcomes of patients treated with immune checkpoint inhibitors: a retrospective cohort study

The use of metformin is associated with survival benefits in patients undergoing immunotherapy.

The Cause of Depression Is Probably Not What You Think

Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells

Long COVID: major findings, mechanisms and recommendations

Revenge is sweet: Experts hope toxin found in SUGAR cane will turn tide on drug-resistant superbugs — calling it the ‘most promising antibiotic in decades’
  • Albicidin is an antibiotic made by disease-causing pathogen in sugar cane leaves
  • Scientists have discovered the molecule blocks infection by changing its shape 
  • New tests showed it is effective against salmonella, E. coli and pneumonia

Effectiveness of Vaccination and Previous Infection Against Omicron Infection and Severe Outcomes in Children Under 12 Years of Age

Immunotherapy with two novel drugs shows activity in colorectal cancer

An Old TB Vaccine Might Help Stave Off Diabetes, Cancer Alzheimer’s, and More 

The BCG vaccine might assist in preventing a range of major diseases

The sooner you expose a baby to a second language, the smarter they’ll be

Just hearing two languages helps babies develop cognitive skills before they even speak. Here’s how – and how you can help them develop those skills.

Harnessing the healing power within our cells

University of Queensland researchers have identified a pathway in cells that could be used to reprogram the body’s immune system to fight back against both chronic inflammatory and infectious diseases.

Scientists detail major mechanism lung cancers use to evade immune attack

COVID Vaccines Are “Obviously Dangerous” And Should Be Halted Immediately, Say Senior Swedish Doctors

Multiple sclerosis (MS): Intestinal bacteria may have an anti-inflammatory effect

Is the Triggering of PD-L1 Dimerization a Potential Mechanism for Food-Derived Small Molecules in Cancer Immunotherapy? A Study by Molecular Dynamics

Natural Active Ingredients and TRPV1 Modulation: Focus on Key Chemical Moieties Involved in Ligand–Target Interaction

Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers

Loss of Epigenetic Information Can Drive Aging, Restoration Can Reverse It

43% of people with COVID-19 get ‘long COVID’

SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19

3-drug combo leads to ‘unprecedented’ response in pancreatic cancer models

Scientists Detail Major Mechanism Lung Cancers Use to Evade Immune Attack

Popular spice duo may ‘significantly’ lower blood sugar levels when combined – 30% drop

Cinnamon, Fenugreek or their combination

COVID-19 is more widespread in animals than we thought

From lions and tigers to big hairy armadillos, a growing number of animals have been infected with the coronavirus. Here’s what we’ve learned.

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

The researchers argue hepatocytes are susceptible to SARS-CoV-2 pseudovirus infection and propose that metformin could be a therapeutic option to attenuate SARS-CoV-2 infection in patients with fatty liver.

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave

How COVID Vaccines Cause Cancer

Lung cancer pill cuts risk of death by half, says ‘thrilling’ study

Taking the drug osimertinib once a day after surgery reduces chance of patients dying by 51%, trials show

El Niño could return in 2023; what that means for the world’s weather

Scientists have found a way to make brain cancer cells die of stress

Aggressive glioblastoma tumours could be in trouble: a breakthrough discovery successfully wiped out cancer cells in mice. Researchers have developed a method that could cause cancerous cells to die of stress.

Beware the Splice of Life: This Killer Protein Causes Pancreatic Cancer

Researchers at the Cold Spring Harbor Laboratory found that the protein SRSF1, which regulates RNA splicing, plays a critical role in the development of pancreatic ductal adenocarcinoma (PDAC), a deadly form of pancreatic cancer. Elevated levels of SRSF1 lead to inflammation and stimulate tumor growth, while restoring normal levels halts the disease’s progress.

Beware the Splice of Life: This Killer Protein Causes Pancreatic Cancer

It Took Researchers Decades to Figure Out This Ancient Device “Too Advanced to be Real”

These microbes found in tumors promote cancer. What if we just kill them?

​New studies show that bacteria help cancer cells evade the body’s immune response. Experts say this relationship could prove vital for wiping out cancer.

‘Tipping the balance’ of immune cells from bad to good reverses multiple sclerosis symptoms in mice

Canadian researchers find brain inflammation in patients with long COVID

Warming climate could turn ocean plankton microbes into carbon emitters

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

Repurposing of Benzimidazole Anthelmintic Drugs as Cancer Therapeutics

Niclosamide is a potential candidate for the treatment of chemo-resistant osteosarcoma

Commiphora myrrh: a phytochemical and pharmacological update

Cytotoxic Activity of Pineapple (Ananas comosus L.) Against Cancer Cells

Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases

Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness

A Magic Remedy of Castor Oil

Anthelmintic Drugs as Emerging Immune Modulators in Cancer

Drug Repurposing Flubendazole to Suppress Tumorigenicity via PCSK9-dependent Inhibition and Potentiate Lenvatinib Therapy for Hepatocellular Carcinoma

Benzimidazole carbamate induces cytotoxicity in breast cancer cells via two distinct cell death mechanisms

Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics

Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems

Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials

Novel olive oil phenolic (−)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities

Niacin / B3 – Taking Too Much of This Common Vitamin May Cause Vision Loss and Liver Damage

Metformin – New study from UMN researchers says an existing drug is a promising treatment for long COVID

Metformin, a medication typically used as a treatment for Type 2 diabetes, has shown promise as an effective treatment for long COVID

Protection from metformin is even stronger among unvaccinated, women and younger adults, analysis shows.

Researchers visualize communication of G protein-coupled receptors, paving way for new drug discovery

Octopuses Can Rewire Their ‘Brains’ by Editing Their Own RNA on The Fly

Archaeologists Find Three Shipwrecks In the Mediterranean’s Treacherous Keith Reef

Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR

Chinese quantum computer is 180 million times faster on AI-related tasks, says team led by ‘father of quantum’ Pan Jianwei

Jiuzhang computer took less than a second for a task that the fastest classical supercomputer in the world would take nearly five years to solve



Director Oliver Stone passionately presents the possibility of meeting the challenge through the power of nuclear energy.

Instead of starving a cancer, researchers go after its defenses
Oxygen deprivation can propel tumor growth and spread

Researchers test drug combination as means to prevent drug resistance in cancer cells

Is Methylation Good or Bad?

Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays

Study Finds Sucralose Produces Previously Unidentified Metabolites

The systemic hallmarks of cancer

Team discovers new organelle involved in cancer metastasis

PEA – Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain

Ginger – 6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death

The Hallmarks of Cancer as Ecologically Driven Phenotypes

The Fascinating Effects of Baicalein on Cancer

New research discovers new cause of cancer coming from inside us

Australian cancer researchers have made an important new connection between a person’s cancer risk and the functions of circular RNAs, a recently discovered family of genetic fragments present within our cells.

Digestion of artificial sweetener sucralose appears to create metabolite that damages DNA

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers

Curcumin can suppress metastasis of colorectal cancer cells by activating a specific signaling pathway

Antihistamine Sparks Hope for Myelin Repair in Multiple Sclerosis

Augusta University researchers find potential lung cancer treatment in CBD

Engineered white blood cells can eliminate cancer

Bird Brains Can Sense Magnetic Fields With The Flick of a Switch

Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection

Research Finds Skipping Breakfast May Compromise the Immune System

Mount Sinai Research Finds Skipping Breakfast May Compromise the Immune System

Could your gut bacteria influence how intelligent you are?

People who are genetically predisposed to have higher levels of Fusicatenibacter bacteria scored better on verbal and mathematical tests, while those with more Oxalobacter scored lower

The Dual Role of the Natural Compound Cardamonin in Triple Negative Breast Cancer

Cardamonin from Cardamom seed spice – In conclusion, the results suggest that cardamonin may have a therapeutic potential to decrease the levels of PD-L1 in the tumor microenvironment combating the cancer cells’ effectiveness in evading the immune system.

The natural chalcone cardamonin selectively induces apoptosis in human neuroblastoma cells

Study reveals how treatment-resistant prostate cancer provides its own hormonal fuel

Study reveals how treatment-resistant prostate cancer provides its own hormonal fuel

Repeated COVID-19 Vaccination Weakens Immune System

Not all benzimidazole derivatives are microtubule destabilizing agents

Modulating the tumor microenvironment improves antitumor effect of anti-PD-L1 mAb in breast cancer

In Situ Tumor Vaccine for Lymph Nodes Delivery and Cancer Therapy Based on Small Size Nanoadjuvant