Science papers reference (unsorted)

Here we collect a list of links to interesting and valued science papers and press articles as our reference to the research on medicine and specially oncology.

We recommend to check these information blog on all Cannabinioid research related topics: http://www.thctotalhealthcare.com

An article about the Ben Williams case:
https://www.telegraph.co.uk/lifestyle/wellbeing/healthadvice/11424747/The-professor-who-cured-his-cancer-with-a-cocktail-of-everyday-pills-and-20-years-on-remains-disease-free.html

His regime: https://virtualtrials.com/pdf2017/treatment_options_gbm_2017.pdf

Unsorted link collection:

Celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy

https://doi.org/10.20517/2394-4722.2018.42

Treatment of hepatocarcinoma with Celecoxib and Pentoxifylline

https://www.longdom.org/open-access/management-of-hepatocarcinoma-with-celecoxib-and-pentoxifylline-report-of-three-cases-2161-1459-1000255.pdf

https://www.medigraphic.com/pdfs/imss/im-2018/im183o.pdf

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

https://doi.org/10.1093/neuonc/nop046

Oridonin inhibits metastasis of human ovarian cancer cells by suppressing the mTOR pathway

https://doi.org/10.5114/aoms.2018.77068

Simvastatin in combination with bergamottin potentiates TNF induced apoptosis through modulation of NF B signalling pathway in human CML

https://doi.org/10.3109/13880209.2016.1141221

Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth

https://doi.org/10.1016/j.ygyno.2019.05.022

Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death

http://dx.doi.org/10.5483/BMBRep.2011.44.8.517

Nitazoxanide – small molecule promotes b-catenin citrullination and inhibits Wnt signaling in cancer

http://dx.doi.org/10.1038/nchembio.2510

NICLOSAMIDE FOR THE TREATMENT OF CANCER METASTASES

US patent: US20140294957A1

https://patents.google.com/patent/US20140294957A1/en

NICLOSAMIDE AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF SOLID TUMORS

US patent: US9844522B2

https://patents.google.com/patent/US9844522B2/ja

Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation

http://dx.doi.org/10.1016/j.antiviral.2016.12.002

Drug Repurposing of the Anthelmintic Niclosamide to Treat Multidrug-Resistant Leukemia

https://doi.org/10.3389/fphar.2017.00110

Multi-targeted therapy of cancer by Niclosamide: A new application for an old drug

http://dx.doi.org/10.1016/j.canlet.2014.04.003

Niclosamide: Beyond an antihelminthic drug

http://dx.doi.org/10.1016/j.cellsig.2017.04.001

Niclosamide inhibits the proliferation of human osteosarcoma cell lines by inducing apoptosis and cell cycle arrest

https://www.spandidos-publications.com/or/33/4/1763

Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities

https://doi.org/10.1016/j.ejpb.2019.05.004

Drug repurposing to overcome resistance to various therapies for colorectal cancer

https://doi.org/10.1007/s00018-019-03134-0

The Use of Endogenous and Synthetic Cannabinoids in Prostate Cancer Therapy – Thesis

https://tspace.library.utoronto.ca/handle/1807/91450

Targeting the endocannabinoid system in cancer therapy: A call for further research

https://www.researchgate.net/publication/11330003_Targeting_the_endocannabinoid_system_in_cancer_therapy_A_call_for_further_research

The Effects of Cannabidiol and – Tetrahydrocannabinol Concentration on Breast Cancer Cell Viability

https://digscholarship.unco.edu/honors/23?utm_source=digscholarship.unco.edu%2Fhonors%2F23&utm_medium=PDF&utm_campaign=PDFCoverPages

https://www.embopress.org/lookup/doi/10.15252/emmm.201809034

Cannabinoid pharmacology and therapy in gut disorders

https://doi.org/10.1016/j.bcp.2018.07.048

Towards natural mimetics of metformin and rapamycin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723685/

The CB 2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway

http://dx.doi.org/10.1016/j.yexcr.2006.03.009

Retinoic Acid Receptor b Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC231096/

Melatonin Can Strengthen the Effect of Retinoic Acid in HL-60 Cells

http://dx.doi.org/10.3390/ijms19102873

The success and the challenge of all-trans retinoic acid in the treatment of cancer

https://doi.org/10.1080/10408398.2018.1509201

Therapeutic Targeting of Autophagy

http://dx.doi.org/10.1016/j.ebiom.2016.10.034

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

https://www.ncbi.nlm.nih.gov/pubmed/28279189

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

http://dx.doi.org/10.1038/tp.2012.15

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

https://doi.org/10.1016/j.ccell.2018.12.012

Synthetic Cannabinoid Activity Against Colorectal Cancer Cells

https://doi.org/10.1089/can.2018.0065

Disulfiram reduces metastatic osteosarcoma tumor burden in an immunocompetent Balb/c or-thotopic mouse model

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059028/

Anti-cancer effects of disulfiram in head and neck squamous cell carcinoma via autophagic cell death

https://doi.org/10.1371/journal.pone.0203069

Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Tumor Growth in Transgenic Apc Min Mice, Correlating with CB1 Receptor Up-Regulation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372501/

Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptos is and Inhibition of Metastasis

http://dx.doi.org/10.1016/j.celrep.2016.12.051

Anticancer Activity and Mechanism of Xanthohumol – A Prenylated Flavonoid From Hops

https://doi.org/10.3389/fphar.2018.00530

Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies

http://dx.doi.org/10.1016/j.ejphar.2015.12.017

The Utility of Chloroquine in Cancer Therapy

https://www.ncbi.nlm.nih.gov/pubmed/25734693

NF-kB activation induced by chloroquine requires autophagosome p62, and JNK signaling and promotes tumor cell resistance

http://www.jbc.org/cgi/doi/10.1074/jbc.M116.756536

Inhibition of autophagy with chloroquine is effective in melanoma

http://dx.doi.org/10.1016/j.jss.2013.04.055

Ferroquine, the next generation antimalarial drug, has antitumor activity

https://www.nature.com/articles/s41598-017-16154-2

Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295448/

Inhibitory effect of Disulfiram copper complex on non-small cell lung cancer cells

http://dx.doi.org/10.1016/j.bbrc.2014.03.047

Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 Domain–Mediated PUMA Degradation

http://dx.doi.org/10.1038/jid.2013.56

Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells

http://europepmc.org/abstract/med/16413786

Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1

http://dx.doi.org/10.1002/stem.1746

Chloroquine and hydroxychloroquine as anti-cancer agents

https://doi.org/10.3332/ecancer.2017.781

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

http://dx.doi.org/10.1016/j.ejphar.2009.06.063

Suppressing autophagy enhances disulfiram/copper-induced apoptosis in non-small cell lung cancer

https://doi.org/10.1016/j.ejphar.2018.02.039

Autophagy Modulation in Cancer – Current Knowledge on Action and Therapy

https://doi.org/10.1155/2018/8023821

Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis

http://dx.doi.org/10.1016/j.jphs.2014.09.001

Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy

http://dx.doi.org/10.1016/j.tiv.2017.10.002

Oridonin inhibits BxPC-3 cell growth through cell apoptosis

https://doi.org/10.1093/abbs/gmu134

Disulfiram inhibits activating transcription factor cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease

Disulfiram and zinc gluconate reduce hepatic tumor volume in a patient with metastatic ocular melanoma. Computed axial tomograms (top)
and positron emission spectrographs (bottom) of a 64-year-old woman with stage IV ocular melanoma metastatic to the liver. Before treatment, she had a
5.5 cm central liver metastasis (white arrows). After 3 months of treatment with disulfiram (500 mg/d) and zinc gluconate (50 mg thrice daily), the hepatic
metastasis had decreased in volume by >50% in both scans (white arrows). After continuing treatment with disulfiram (250 mg/d) and the same dose of
zinc gluconate, the lesion remained stable in size at 10 and 14 months (white arrows). She continues to be clinically well and free of drug side effects on
disulfiram and zinc gluconate. After 53 continuous months of treatment with this regimen, she has experienced no quantifiable malignant progression. A
follow-up abdominal computed tomography scan after 42 months of therapy shows that the hepatic tumor burden has remained small.

See also U.S. patents No. 6,548,540 and 6,589,987

http://mct.aacrjournals.org/content/3/9/1049.long

The cytotoxic mechanisms of disulfiram and copper in cancer cells

https://pubs.rsc.org/en/content/articlelanding/2015/tx/c5tx00210a

CANNABIDIOL (CBD) Pre-Review Report Expert Committee 5.2 WHO

Under experimental conditions,it has been demonstrated that heating CBD in solutions of some acidscatalysescyclizations within the CBDmolecule resulting in delta-9-THC[28]. Gaoni and Mechoulam have published several papers regarding methods of converting CBD to other cannabinoids including THC, however the yields vary and purity is unclear. [9]A version of thismethod has been reported on a drug user forum. Itsuggests dissolving CBD in sulphuric acid/acetic acid and leaving it for anywhere from3 hours to 3 days to obtain delta-9-THC and delta-8-THC. After 3 hours, the author states that CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.

https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation

https://www.karger.com/Article/FullText/356446

Future Aspects for Cannabinoids in Breast Cancer Therapy

http://dx.doi.org/10.3390/ijms20071673

The Endocannabinoid System as a Target in Cancer Diseases

https://doi.org/10.3389/fphar.2019.00339

Antitumor Cannabinoid Chemotypes – Structural Insights

https://doi.org/10.3389/fphar.2019.00621

CANNABINOIDS INCREASE LUNG CANCER CELL LYSIS BY LYMPHOKINE-ACTIVATED KILLER CELLS VIA UPREGULATION OF ICAM-1

http://dx.doi.org/doi:10.1016/j.bcp.2014.07.014

Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines

https://doi.org/10.1016/j.breast.2018.06.009

Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells

https://doi.org/10.1016/j.canlet.2019.01.011

Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer

http://dx.doi.org/10.3390/cancers11050642

Silibinin to improve cancer therapeutics, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator

https://doi.org/10.1016/j.lfs.2018.10.009

Melanoma Cell Death Mechanisms

https://doi.org/10.4068/cmj.2018.54.3.135

Natural Forms of Vitamin E and Metabolites Regulation of Cancer Cell Death and Underlying Mechanisms

https://doi.org/10.1002/iub.1978

Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells

http://dx.doi.org/10.3390/ijms20020399

Silibinin, A Natural Blend In Polytherapy Formulation For Targeting CD44V6 Expressing Colon Cancer Stem Cells

https://www.nature.com/articles/s41598-018-35069-0

Targeting Autophagy Using Natural Compounds for Cancer Prevention and Therapy

https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.31978

Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell Lines – Possible Implications in New Therapeutic Strategies

http://dx.doi.org/10.3390/ijms20051199

p53 Signaling in Cancers

http://dx.doi.org/10.3390/cancers11030332

Resveratrol inhibited the progression of human hepatocellular carcinoma by inducing autophagy via regulating p53 and the phosphoinositide 3‑kinase protein kinase B pathway

https://doi.org/10.3892/or.2018.6648

Role of Autophagy in Apoptotic Regulation by Akt in Pancreatic Cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565513

Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions

http://dx.doi.org/10.1016/j.bbrc.2015.05.022

Doxycycline, Azithromycin and Vitamin C (DAV) – A potent combination therapy for targeting mitochondria and eradicating cancer stem cells

https://dx.doi.org/10.18632%2Faging.101905

Vitamin C and Doxycycline – A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

https://dx.doi.org/10.18632%2Foncotarget.18428

The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

https://doi.org/10.1371/journal.pntd.0006715

NSAID celecoxib – a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy

http://dx.doi.org/10.20517/2394-4722.2018.42

Treatment of hepato carcinoma with celecoxib and pentoxifylline – a
case report

http://www.marine-science.news/Treatment_of_hepato_carcinoma_with_celecoxib_and_pentoxifylline-a_case_report.pdf

β-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK ERK and PI3K Akt mTOR Signalling Pathways

http://dx.doi.org/10.7314/APJCP.2012.13.6.2739

Inhibitory effect of β-elemene on human breast cancer cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129006/

Anti-Cancer Properties of Nigella Sativa Essential Oils and their Major Constituents, Thymoquinone and beta-Elemene

https://doi.org/10.2174/157488409787236137

Repurposed drugs schema – Astrocytoma

Cannabinoid-induced cell death in endometrial cancer cells- involvement of TRPV1 receptors in apoptosis

https://link.springer.com/article/10.1007/s13105-018-0611-7

β-elemene against Burkitt’s lymphoma via activation of PUMA mediated apoptotic pathway

https://doi.org/10.1016/j.biopha.2018.07.124

Pentoxifylline-Induced Apoptosis in Chronic Lymphocytic Leukemia – New Insights into Molecular Mechanism

https://doi.org/10.2174/1389557517666171002162258

Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells

https://doi.org/10.3892/ijo.2018.4272

Melatonin‐mediated regulation of autophagy – Making sense of double‐edged sword in cancer

https://doi.org/10.1002/jcp.28435

Melatonin – A new inhibitor agent for cervical cancer treatment

https://doi.org/10.1002/jcp.28865

Immunoregulatory role of melatonin in cancer

https://doi.org/10.1002/jcp.29036

Melatonin inhibits lung metastasis of gastric cancer in vivo

https://doi.org/10.1016/j.biopha.2019.109018

Clock genes and the role of melatonin in cancer cells

https://doi.org/10.32794/mr11250026

Melatonin as a potential inhibitor of colorectal cancer

http://dx.doi.org/10.1002/jcb.28833

Melatonin and non-small cell lung cancer

https://doi.org/10.1186/s12935-019-0853-7

Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death

https://doi.org/10.1186/s12935-019-0777-2

Metformin as an anti-cancer agent – actions and mechanisms targeting cancer stem cells

https://doi.org/10.1093/abbs/gmx106

The Endocannabinoid System, Our Universal Regulator

https://www.jyi.org/2018-june/2018/6/1/the-endocannabinoid-system-our-universal-regulator

Targeting colon cancer stem cells with novel blood cholesterol drug pitavastatin

https://www.europeanreview.org/article/12394

Pitavastatin suppressed liver cancer cells in vitro and in vivo

http://dx.doi.org/10.2147/OTT.S106906

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation

https://www.nature.com/articles/s41419-018-0733-4

Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation

https://doi.org/10.1186/s13046-019-1242-8

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279420/

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells

https://doi.org/10.1155/2018/3853409

Proscillaradin A – From Cardiac Glycosides to Cancer Therapeutics

http://dx.doi.org/10.17582/journal.pujz/2018.33.2.205.209

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673260/

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146931

Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278877/

Metformin and Prostate Cancer – a New Role for an Old Drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405102/

Evaluation of Cytotoxic Effects and Underlying Mechanisms of Disulfiram on Breast Cancer Cell Lines

https://refubium.fu-berlin.de/handle/fub188/23438

Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981123/

Repurposing disulfiram for treatment of Staphylococcus aureus infections

https://doi.org/10.1016/j.ijantimicag.2019.03.024

Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma

https://www.mdpi.com/2077-0383/8/5/611

Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis

http://dx.doi.org/10.3390/antibiotics8020072

Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents

http://dx.doi.org/10.3389/fphar.2016.00361

Novel combination of thymoquinone and resveratrol enhances anticancer effect on hepatocellular carcinoma cell line

https://doi.org/10.1016/j.fjps.2017.08.001

Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive

http://dx.doi.org/10.1016/j.jaim.2016.07.004

Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer

http://dx.doi.org/10.1016/j.apjtm.2017.03.026

Thymoquinone antioxidant pro-oxidant effect as potential anticancer remedy

https://doi.org/10.1016/j.biopha.2019.108783

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress

https://onlinelibrary.wiley.com/doi/10.1002/jcb.27369

Anti-tumor and Anti-angiogenic Effects of Aspirin-PC in Ovarian Cancer

http://mct.aacrjournals.org/content/early/2016/09/16/1535-7163.MCT-16-0074

Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells

https://doi.org/10.1155/2019/3689517

The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress

http://dx.doi.org/10.1155/2016/7831282

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

http://dx.doi.org/10.3978/j.issn.2305-5839.2014.06.03

Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways

https://www.nature.com/articles/s41598-018-30158-6

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

http://dx.doi.org/10.3390/molecules24112152

Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines

https://www.ncbi.nlm.nih.gov/pubmed/23884106

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

https://link.springer.com/article/10.1007%2Fs00432-013-1539-5

Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

http://www.bloodjournal.org/content/115/23/4824

Mutations in tumor suppressor p53 and deregulation of cellular metabolism

https://edoc.hu-berlin.de/handle/18452/20285

Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

https://www.spandidos-publications.com/10.3892/ijo.2018.4259

Piperlongumine induces autophagy by targeting p38 signaling

https://www.nature.com/articles/cddis2013358

Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K Akt mTOR pathway

https://doi.org/10.1177%2F0394632015598849

MECHANISMS OF PIPERLONGUMINE-INDUCED CANCER CELL DEATH

https://library.ndsu.edu/ir/handle/10365/25178

11 Oncologic Emergencies You Need to Know

https://reference.medscape.com/slideshow/oncologic-emergencies-6011636

Lemongrass essential oil and citral inhibit Src Stat3 activity and suppress the proliferation survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents

https://www.spandidos-publications.com/ijo/52/5/1738

Drug Repurposing for the Treatment of Acute Myeloid Leukemia

https://doi.org/10.3389/fmed.2017.00211

The Anthelmintic Flubendazole Blocks Human Melanoma Growth and Metastasis and Suppresses Programmed Cell Death Protein-1 and Myeloid-Derived Suppressor Cell Accumulation

https://doi.org/10.1016/j.canlet.2019.05.026

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index

http://dx.doi.org/10.1101/688192

Seaweeds-derived compounds modulating effects on signal transduction pathways – A systematic review

https://doi.org/10.1016/j.phymed.2019.153016

Thymoquinone enhanced the tumoricidal activity of NK Cells against Lung Cancer

https://www.jimmunol.org/content/200/1_Supplement/124.5

Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive

http://dx.doi.org/10.1016/j.jaim.2016.07.004

Anatomy of the Lymphatic and Immune Systems

Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells

https://www.spandidos-publications.com/ijo/45/1/209

Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin

https://www.spandidos-publications.com/10.3892/ol.2015.3273

The Anticancer Properties of Cordycepin and Their Underlying Mechanisms

http://dx.doi.org/10.3390/ijms19103027

Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses

https://www.frontiersin.org/articles/10.3389/fphar.2018.00355/full

Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis

http://dx.doi.org/10.1016/j.jphs.2014.09.001

Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy

http://dx.doi.org/10.1016/j.tiv.2017.10.002

Disulfiram – AGENT FOR CONTROLLING CELLS CONSTITUTING CANCER MICROENVIRONMENT OR INFLAMMATORY MICROENVIRONMENT

https://patents.google.com/patent/US20180000755A1/en

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8 + T Cells

https://doi.org/10.1016/j.immuni.2019.06.002

Disulfiram with or without metformin inhibits oesophageal squamous cell carcinoma in vivo

https://doi.org/10.1016/j.canlet.2017.12.026

Eradication of spontaneous malignancy by local immunotherapy

https://stm.sciencemag.org/content/10/426/eaan4488.short

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

https://doi.org/10.1038/nrc2196

High Dose Intravenous Vitamin C and Long Time Survival of a Patient With Cancer of Head of the Pancreas

http://www.orthomolecular.org/library/jom/1995/pdf/1995-v10n02-p087.pdf

Mechanisms of anti-cancer effects of ascorbate – Cytotoxic activity and epigenetic modulation

http://dx.doi.org/10.1016/j.bcmd.2017.09.005

Effect of high-dose intravenous vitamin C on inflammation in cancer patients

http://www.translational-medicine.com/content/10/1/189

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

https://science.sciencemag.org/content/350/6266/1391

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

https://doi.org/10.1016/j.chest.2016.11.036

Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2

https://doi.org/10.1038/s41698-017-0044-8

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

http://www.nature.com/doifinder/10.1038/nature25016

Disulfiram Facilitates Intracellular Cu Uptake and Induces Apoptosis in Human Melanoma Cells

https://pubs.acs.org/doi/abs/10.1021/jm049568z

Targeting flavin‐containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration – Vitamin B2 (Riboflavin)
in cancer therapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764395/

Magnolol induces apoptosis via caspase-independent pathwaysin non-small cell lung cancer cells

https://www.sci-hub.se/10.1007/s12272-013-0232-1

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

http://www.translational-medicine.com/content/12/1/163

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

http://www.pnas.org/cgi/doi/10.1073/pnas.1703921114

Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells

https://www.spandidos-publications.com/10.3892/or.2015.4091

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

http://dx.doi.org/10.7554/eLife.19671

NF-κB activation induced by chloroquine requires autophagosome, p62, and JNK signaling and promotes tumor cell resistance

http://www.jbc.org/content/292/8/3379

Disulfiram combined with copper inhibits metastasis and epithelial–mesenchymal transition in hepatocellular carcinoma through the NF-jB and TGF-b pathways

https://doi.org/10.1111/jcmm.13334

Evidence for the efficacy of disulfiram and copper combination in glioblastoma multiforme – A propos of a case

https://www.jbuon.com/archive/22-5-1227.pdf

Repositionierung von Disulfiram zur Therapie des Ovarialkarzinoms

https://edoc.ub.uni-muenchen.de/20629/7/Papaioannou_Margarita.pdf

Disulfiram copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

http://dx.doi.org/10.1038/cddis.2017.176

Disulfiram modulated ROS–MAPK and NFkB pathways and targeted breast cancer cells with cancer stem cell-like properties

https://www.nature.com/articles/bjc2011126

Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway

http://dx.doi.org/10.1016/j.biopha.2013.03.020

Anticancer adjuvant containing pentoxifylline Patent US 20150374702

https://patents.google.com/patent/US20150374702

Potentiation of Anticancer Drugs: Effects of Pentoxifylline on Neoplastic Cells

https://www.mdpi.com/1422-0067/13/1/369

Pentoxifylline triggers autophagy via ER stress response that interferes
with Pentoxifylline induced apoptosis in human melanoma cells

http://dx.doi.org/10.1016/j.bcp.2015.12.018

Pentoxifylline- rescue for the oncological patient. Anticancer and protective properties of an alkaloid derivative

https://pdfs.semanticscholar.org/51b4/7e2be711fbe3666721bc7829aebb07246c2b.pdf

Disulfiram Induces Apoptosis in Human Melanoma Cells: A Redox-related Process

http://mct.aacrjournals.org/content/1/3/197.long

The Efficacy of Dandelion Root Extract in Inducing Apoptosis in Drug-Resistant Human Melanoma Cells

https://www.hindawi.com/journals/ecam/2011/129045/

Ligands for cannabinoid receptors, promising anticancer agents

http://dx.doi.org/10.1016/j.lfs.2015.12.053

beta-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

http://dx.doi.org/10.1016/j.canlet.2011.08.001

A Brief Overview on Natural Killer Cells

http://dx.doi.org/10.5772/intechopen.72328

Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342717/

Lung cancer stem cells: The root of resistance

http://dx.doi.org/10.1016/j.canlet.2016.01.012

CANNABIS for the treatment of cancer – The anticancer activity of phytocannabinoids and endocannabinoids – by Justin Kander

http://www.marine-science.news/Cannabis_and_Cancer.pdf

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

https://academic.oup.com/carcin/article/38/2/119/2709442

Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Tumor Growth in Transgenic Apc Min + Mice, Correlating with CB1 Receptor Up-Regulation

https://www.mdpi.com/1422-0067/18/3/485

Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization

http://dx.doi.org/10.1080/23723556.2015.1006077

Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil

https://www.intechopen.com/books/olive-oil-constituents-quality-health-properties-and-bioconversions/oleocanthal-a-naturally-occurring-anti-inflammatory-agent-in-virgin-olive-oil

Oleocanthal Attenuates Cell Proliferation, Invasiveness, and Tumor Growth in Breast Cancer Models

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097622

Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190038/

TARGETING THE CANCER METABOLIC PHENOTYPE USING HIGH DOSE VITAMIN B1 THERAPY

https://pdfs.semanticscholar.org/8587/9ad67d0576b44157f83a954f3ae72cbb7b74.pdf

High‑dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate

http://dx.doi.org/DOI:10.1007/s00280-014-2386-z

Oxidative stress and apoptosis induction in human thyroid carcinoma cells exposed to the essential oil from Pistacia lentiscus aerial parts (Mastic oil)

http://dx.doi.org/DOI:10.1371/journal.pone.0172138

Epigenetic mechanisms and endocannabinoid signalling

https://doi.org/10.1111/febs.12125

The endocannabinoid signaling system in cancer

http://dx.doi.org/10.1016/j.tips.2013.03.003

In Vitro Investigation of the Potential Immunomodulatory and Anti-Cancer Activities of Black Pepper (Piper nigrum) and Cardamom (Elettaria cardamomum)

https://doi.org/10.1089/jmf.2009.1131

Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines

http://dx.doi.org/10.3390/ijms20051203

Analyzing bioactive effects of the minor hop compound xanthohumol C on human breast cancer cells using quantitative proteomics

https://doi.org/10.1371/journal.pone.0213469

Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines

https://doi.org/10.1371/journal.pone.0213776

Oridonin inhibits the proliferation, migration and invasion of human osteosarcoma cells via suppression of matrix metalloproteinase expression and STAT3 signalling pathway

https://jbuon.com/archive/24-3-1175.pdf

The metabolic advantage of tumor cells

http://www.molecular-cancer.com/content/10/1/70

PHYTO-PHARMACOLOGICAL PROFILE OF HUMULUS LUPULUS

https://pdfs.semanticscholar.org/d66f/ea4d38ba8ab88b902fb95112b91da566e217.pdf

Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

https://doi.org/10.1002/ijc.32285

Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies

http://dx.doi.org/10.1080/2162402X.2015.1066062

Polo-like Kinase 1 inhibition as a therapeutic approach to selectively 1 target BRCA1-deficient cancer cells by synthetic lethality induction

http://dx.doi.org/DOI:10.1158/1078-0432.CCR-18-3516

MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression

http://dx.doi.org/10.1101/573931

Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions

http://dx.doi.org/10.3390/nu11020467

COMBINED PHYTOCHEMICALS SYNERGISTICALLY RESTRAIN BREAST CANCER IN CULTURED CELLS AND XENOGRAFT MICE – Indole-3-Carbinol

https://search.proquest.com/openview/e4a698fb1ae574f5e9aa823e6981bea2

Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells

https://www.researchgate.net/publication/317604765_Synergistic_Anticancer_Effects_of_Silibinin_and_Chrysin_in_T47D_Breast_Cancer_Cells

COMBINATIONS OF DRUGS (E.G., A BENZIMIDAZOLE AND PENTAMIDINE) FOR THE TREATMENT OF NEOPLASTIC DSORDERS – U.S. Patent US6693125B2

https://patents.google.com/patent/US6693125B2/en

Role of Melatonin in Cancer Treatment

http://ar.iiarjournals.org/content/32/7/2747.long

Antihelminthic drugs as a treatment for hyperproliferative diseases

https://pdfs.semanticscholar.org/6dd9/332c998979d15a8edadcf721211d936fc8f9.pdf

Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects

https://doi.org/10.1016/j.neuroimage.2019.04.009

Cancer stem cells – Road to therapeutic resistance and strategies to overcome resistance

https://doi.org/10.1016/j.bbadis.2018.11.015

The novel role of pyrvinium in cancer therapy – Pyrvinium and inhibition of Hippo pathway

https://doi.org/10.1002/jcp.26006

Inhibitory effect of pyrvinium pamoate on uveal melanoma cells involves blocking of Wnt/β-catenin pathway

https://academic.oup.com/abbs/article/49/10/890/4097565

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration

http://www.frontiersin.org/Oncology/editorialboard

Cytotoxic Effects of Artemisia annua L. and Pure Artemisinin on the D-17 Canine Osteosarcoma Cell Line

https://doi.org/10.1155/2019/1615758

MICROTUBULES AS A TARGET FOR ANTICANCER DRUGS

https://www.nature.com/articles/nrc1317

Melatonin: An important anticancer agent in colorectal cancer

https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29049

In vitro investigation of anti-cancer activity of propolis on hepatocellular carcinoma cells

http://www.medicinescience.org/wp-content/uploads/2019/03/53-1547584461MS-2019-01-09.pdf

Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines

https://doi.org/10.1080/10520295.2019.1589574

Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics

https://doi.org/10.1186/s12906-019-2505-9

Anticancer Activity and Underlying Mechanism of Phytochemicals against Multiple Myeloma

http://dx.doi.org/10.3390/ijms20092302

Insights on the Multifunctional Activities of Magnolol

https://doi.org/10.1155/2019/1847130

Grape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K Akt signaling pathway

http://doi.org/10.2147/OTT.S195615

Anti-cancer effects of cinnamon – Insights into its apoptosis effects

https://doi.org/10.1016/j.ejmech.2019.05.067

Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity – Molecular Evidence

http://dx.doi.org/10.3390/md17060338

Pharmacoepigenetics of Chinese Herbal Components in Cancer

https://doi.org/10.1016/B978-0-12-813939-4.00035-8

Suppression of colorectal cancer cell growth by combined treatment of 6‑gingerol and γ‑tocotrienol via alteration of multiple signalling pathways

https://doi.org/10.1007/s11418-019-01323-6

Natural products for treating colorectal cancer – A mechanistic review

https://doi.org/10.1016/j.biopha.2019.109142

Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0 G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways

https://jbuon.com/archive/24-3-975.pdf

Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR PI3K AKT signalling pathway

https://jbuon.com/archive/24-3-990.pdf

Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo

https://doi.org/10.1016/j.carbpol.2019.115034

Bioactive Compounds and Biological Functions of Garlic (Allium sativum)

http://dx.doi.org/10.3390/foods8070246

Effects of Curcumin on Ion Channels and Pumps

https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/iub.2054

Cardamonin Induces Cell Cycle Arrest, Apoptosis and Alters Apoptosis Associated Gene Expression in WEHI-3 Mouse Leukemia Cells

http://dx.doi.org/10.1142/S0192415X19500332

Honokiol induces apoptosis and suppresses migration and invasion of ovarian carcinoma cells via AMPK/mTOR signaling pathway

https://www.spandidos-publications.com/10.3892/ijmm.2019.4122

Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor

http://dx.doi.org/10.3390/cancers11010022

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice – Ivermectin

http://www.pnas.org/cgi/doi/10.1073/pnas.1517188113

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

https://doi.org/10.1016/j.bbrc.2018.02.063

Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage

http://dx.doi.org/10.1016/j.bbrc.2017.08.097

Cimetidine as an anti-cancer agent

https://ecancer.org/journal/8/full/485-repurposing-drugs-in-oncology-redo-cimetidine-as-an-anti-cancer-agent.php

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.16093

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

https://doi.org/10.1016/j.bbrc.2018.02.063

Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress

http://dx.doi.org/10.1016/j.bbrc.2016.10.064

The anti parasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

https://doi.org/10.1182/blood-2010-01-262675

Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway

https://doi.org/10.1111/cpr.12543

Ivermectin as an inhibitor of cancer stem‑like cells

https://www.spandidos-publications.com/10.3892/mmr.2017.8231

Ivermectin – Old Drug, New Tricks

http://dx.doi.org/10.1016/j.pt.2017.02.004

The multitargeted drug ivermectin – from an antiparasitic agent to a repositioned cancer drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/

Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs

https://doi.org/10.1016/j.bmcl.2019.04.045

Gut microbiota, inflammation and colorectal cancer

http://dx.doi.org/10.1016/j.gendis.2016.03.004

Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways

http://dx.doi.org/10.1016/j.canlet.2014.02.026

α‑MMC and MAP30, two ribosome‑inactivating proteins extracted from Momordica charantia, induce cell cycle arrest and apoptosis in A549 human lung carcinoma cells

https://www.spandidos-publications.com/10.3892/mmr.2015.3176

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

https://doi.org/10.3389/fphar.2019.00486

Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

http://www.pnas.org?cgi?doi?10.1073?pnas.0408340102

Induction of Tumor Cytotoxic Immune Cells Using a Protein from the Bitter Melon (Momordica charantia)

https://doi.org/10.1016/0008-8749(90)90321-H

Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways

https://www.hindawi.com/journals/ecam/2012/261971/

MOMORDICA CHARANTIA LINN. (KARELA) – NATURE’S SILENT HEALER

https://www.researchgate.net/publication/285966662_Momordica_charantia_linn_Karela_Nature’s_silent_healer

Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions

https://doi.org/10.3389/fphar.2019.00321

Vitamin E – Regulatory Role on Signal Transduction

https://doi.org/10.1002/iub.1986

Natural Forms of Vitamin E and Metabolites – Regulation of Cancer Cell Death and Underlying Mechanisms

https://doi.org/10.1002/iub.1978

Fucoxanthin induces apoptosis in human glioma cells by triggering ROS-mediated oxidative damage and regulating MAPKs and PI3K AKT pathways

https://pubs.acs.org/doi/10.1021/acs.jafc.8b07126

Icaritin – A Novel Natural Candidate for Hematological Malignancies Therapy

https://doi.org/10.1155/2019/4860268

Albendazole Induces Cell Death in Human Colorectal Cancer Cell Line HT-29

https://www.researchgate.net/publication/329762205_Albendazole_induces_cell_death_in_human_colorectal_cancer_cell_line_HT-29

Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

https://doi.org/10.1002/ijc.31585

Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets

http://dx.doi.org/doi:10.1016/j.drup.2016.03.002

Flubendazole inhibits glioma proliferation by G2 M cell cycle arrest and pro-apoptosis

https://www.nature.com/articles/s41420-017-0017-2

A list of studies about CBD and Cannabinoids

https://www.themcaa.net/list-of-cbds–cannabis-studies.html#

More Scientific Studies Proving Cannabis Fights Cancer:

Cannabis can kill cancer cells!

Uterine, testicular, and pancreatic cancers

Brain cancer

Mouth and throat cancer

Breast cancer

Lung cancer

Prostate cancer

Blood cancer

Skin cancer

Liver cancer

Cannabis cancer cures (general)

Cancers of the head and neck

Cholangiocarcinoma cancer

Leukemia

Cannabis partially/fully induced cancer cell death

Translocation-positive rhabdomyosarcoma

Lymphoma

Cannabis kills cancer cells

Melanoma

Thyroid carcinoma

Colon cancer

Intestinal inflammation and cancer

Cannabinoids in health and disease

Cannabis inhibits cancer cell invasion