Articles and science papers (unsorted part4)

Here we collect a list of links to interesting and valued science papers and press articles as our reference to the research on medicine and specially oncology.

We recommend to check these information blog on all Cannabinioid research related topics:

An article about the Ben Williams case:

His regime:

Celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy

Treatment of hepatocarcinoma with Celecoxib and Pentoxifylline

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

Oridonin inhibits metastasis of human ovarian cancer cells by suppressing the mTOR pathway

Simvastatin in combination with bergamottin potentiates TNF induced apoptosis through modulation of NF B signalling pathway in human CML

Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth

Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death

Nitazoxanide – small molecule promotes b-catenin citrullination and inhibits Wnt signaling in cancer


US patent: US20140294957A1


US patent: US9844522B2

Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation

Drug Repurposing of the Anthelmintic Niclosamide to Treat Multidrug-Resistant Leukemia

Multi-targeted therapy of cancer by Niclosamide: A new application for an old drug

Niclosamide: Beyond an antihelminthic drug

Niclosamide inhibits the proliferation of human osteosarcoma cell lines by inducing apoptosis and cell cycle arrest

Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities

Drug repurposing to overcome resistance to various therapies for colorectal cancer

The Use of Endogenous and Synthetic Cannabinoids in Prostate Cancer Therapy – Thesis

Targeting the endocannabinoid system in cancer therapy: A call for further research

The Effects of Cannabidiol and – Tetrahydrocannabinol Concentration on Breast Cancer Cell Viability

Cannabinoid pharmacology and therapy in gut disorders

Towards natural mimetics of metformin and rapamycin

The CB 2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway

Retinoic Acid Receptor b Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells

Melatonin Can Strengthen the Effect of Retinoic Acid in HL-60 Cells

The success and the challenge of all-trans retinoic acid in the treatment of cancer

Therapeutic Targeting of Autophagy

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation

Synthetic Cannabinoid Activity Against Colorectal Cancer Cells

Disulfiram reduces metastatic osteosarcoma tumor burden in an immunocompetent Balb/c or-thotopic mouse model

Anti-cancer effects of disulfiram in head and neck squamous cell carcinoma via autophagic cell death

Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Tumor Growth in Transgenic Apc Min Mice, Correlating with CB1 Receptor Up-Regulation

Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptos is and Inhibition of Metastasis

Anticancer Activity and Mechanism of Xanthohumol – A Prenylated Flavonoid From Hops

Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies

The Utility of Chloroquine in Cancer Therapy

NF-kB activation induced by chloroquine requires autophagosome p62, and JNK signaling and promotes tumor cell resistance

Inhibition of autophagy with chloroquine is effective in melanoma

Ferroquine, the next generation antimalarial drug, has antitumor activity

Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells

Inhibitory effect of Disulfiram copper complex on non-small cell lung cancer cells

Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 Domain–Mediated PUMA Degradation

Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells

Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1

Chloroquine and hydroxychloroquine as anti-cancer agents

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

Suppressing autophagy enhances disulfiram/copper-induced apoptosis in non-small cell lung cancer

Autophagy Modulation in Cancer – Current Knowledge on Action and Therapy

Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis

Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy

Oridonin inhibits BxPC-3 cell growth through cell apoptosis

Disulfiram inhibits activating transcription factor cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease

Disulfiram and zinc gluconate reduce hepatic tumor volume in a patient with metastatic ocular melanoma. Computed axial tomograms (top)
and positron emission spectrographs (bottom) of a 64-year-old woman with stage IV ocular melanoma metastatic to the liver. Before treatment, she had a
5.5 cm central liver metastasis (white arrows). After 3 months of treatment with disulfiram (500 mg/d) and zinc gluconate (50 mg thrice daily), the hepatic
metastasis had decreased in volume by >50% in both scans (white arrows). After continuing treatment with disulfiram (250 mg/d) and the same dose of
zinc gluconate, the lesion remained stable in size at 10 and 14 months (white arrows). She continues to be clinically well and free of drug side effects on
disulfiram and zinc gluconate. After 53 continuous months of treatment with this regimen, she has experienced no quantifiable malignant progression. A
follow-up abdominal computed tomography scan after 42 months of therapy shows that the hepatic tumor burden has remained small.

See also U.S. patents No. 6,548,540 and 6,589,987

The cytotoxic mechanisms of disulfiram and copper in cancer cells

CANNABIDIOL (CBD) Pre-Review Report Expert Committee 5.2 WHO

Under experimental conditions,it has been demonstrated that heating CBD in solutions of some acidscatalysescyclizations within the CBDmolecule resulting in delta-9-THC[28]. Gaoni and Mechoulam have published several papers regarding methods of converting CBD to other cannabinoids including THC, however the yields vary and purity is unclear. [9]A version of thismethod has been reported on a drug user forum. Itsuggests dissolving CBD in sulphuric acid/acetic acid and leaving it for anywhere from3 hours to 3 days to obtain delta-9-THC and delta-8-THC. After 3 hours, the author states that CBD has been converted into 52% delta-9-THC and 2% delta-8-THC.

Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation

Future Aspects for Cannabinoids in Breast Cancer Therapy

The Endocannabinoid System as a Target in Cancer Diseases

Antitumor Cannabinoid Chemotypes – Structural Insights


Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines

Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells

Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer

Silibinin to improve cancer therapeutics, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator

Melanoma Cell Death Mechanisms

Natural Forms of Vitamin E and Metabolites Regulation of Cancer Cell Death and Underlying Mechanisms

Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells

Silibinin, A Natural Blend In Polytherapy Formulation For Targeting CD44V6 Expressing Colon Cancer Stem Cells

Targeting Autophagy Using Natural Compounds for Cancer Prevention and Therapy

Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell Lines – Possible Implications in New Therapeutic Strategies

p53 Signaling in Cancers

Resveratrol inhibited the progression of human hepatocellular carcinoma by inducing autophagy via regulating p53 and the phosphoinositide 3‑kinase protein kinase B pathway

Role of Autophagy in Apoptotic Regulation by Akt in Pancreatic Cancer

Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions

Doxycycline, Azithromycin and Vitamin C (DAV) – A potent combination therapy for targeting mitochondria and eradicating cancer stem cells

Vitamin C and Doxycycline – A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

NSAID celecoxib – a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy

Treatment of hepato carcinoma with celecoxib and pentoxifylline – a
case report

β-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK ERK and PI3K Akt mTOR Signalling Pathways

Inhibitory effect of β-elemene on human breast cancer cells

Anti-Cancer Properties of Nigella Sativa Essential Oils and their Major Constituents, Thymoquinone and beta-Elemene

Repurposed drugs schema – Astrocytoma

Cannabinoid-induced cell death in endometrial cancer cells- involvement of TRPV1 receptors in apoptosis

β-elemene against Burkitt’s lymphoma via activation of PUMA mediated apoptotic pathway

Pentoxifylline-Induced Apoptosis in Chronic Lymphocytic Leukemia – New Insights into Molecular Mechanism

Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells

Melatonin‐mediated regulation of autophagy – Making sense of double‐edged sword in cancer

Melatonin – A new inhibitor agent for cervical cancer treatment

Immunoregulatory role of melatonin in cancer

Melatonin inhibits lung metastasis of gastric cancer in vivo

Clock genes and the role of melatonin in cancer cells

Melatonin as a potential inhibitor of colorectal cancer

Melatonin and non-small cell lung cancer

Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death

Metformin as an anti-cancer agent – actions and mechanisms targeting cancer stem cells

The Endocannabinoid System, Our Universal Regulator

Targeting colon cancer stem cells with novel blood cholesterol drug pitavastatin

Pitavastatin suppressed liver cancer cells in vitro and in vivo

Proscillaridin A induces apoptosis and suppresses non-small-cell lung cancer tumor growth via calcium-induced DR4 upregulation

Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation

Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells

Proscillaradin A – From Cardiac Glycosides to Cancer Therapeutics

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells

Metformin and Prostate Cancer – a New Role for an Old Drug

Evaluation of Cytotoxic Effects and Underlying Mechanisms of Disulfiram on Breast Cancer Cell Lines

Evaluation of the Cytotoxic and Autophagic Effects of Atorvastatin on MCF-7 Breast Cancer Cells

Repurposing disulfiram for treatment of Staphylococcus aureus infections

Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma

Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis

Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents

Novel combination of thymoquinone and resveratrol enhances anticancer effect on hepatocellular carcinoma cell line

Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive

Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer

Thymoquinone antioxidant pro-oxidant effect as potential anticancer remedy

β‐Caryophyllene, the major constituent of copaiba oil, reduces systemic inflammation and oxidative stress

Anti-tumor and Anti-angiogenic Effects of Aspirin-PC in Ovarian Cancer

Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells

The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

Mutations in tumor suppressor p53 and deregulation of cellular metabolism

Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

Piperlongumine induces autophagy by targeting p38 signaling

Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K Akt mTOR pathway


11 Oncologic Emergencies You Need to Know

Lemongrass essential oil and citral inhibit Src Stat3 activity and suppress the proliferation survival of small-cell lung cancer cells, alone or in combination with chemotherapeutic agents

Drug Repurposing for the Treatment of Acute Myeloid Leukemia

The Anthelmintic Flubendazole Blocks Human Melanoma Growth and Metastasis and Suppresses Programmed Cell Death Protein-1 and Myeloid-Derived Suppressor Cell Accumulation

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index

Seaweeds-derived compounds modulating effects on signal transduction pathways – A systematic review

Thymoquinone enhanced the tumoricidal activity of NK Cells against Lung Cancer

Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive

Anatomy of the Lymphatic and Immune Systems

Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells

Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin

The Anticancer Properties of Cordycepin and Their Underlying Mechanisms

Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses

Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis

Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy


Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8 + T Cells

Disulfiram with or without metformin inhibits oesophageal squamous cell carcinoma in vivo

Eradication of spontaneous malignancy by local immunotherapy

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

High Dose Intravenous Vitamin C and Long Time Survival of a Patient With Cancer of Head of the Pancreas

Mechanisms of anti-cancer effects of ascorbate – Cytotoxic activity and epigenetic modulation

Effect of high-dose intravenous vitamin C on inflammation in cancer patients

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Disulfiram Facilitates Intracellular Cu Uptake and Induces Apoptosis in Human Melanoma Cells

Targeting flavin‐containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration – Vitamin B2 (Riboflavin)
in cancer therapy

Magnolol induces apoptosis via caspase-independent pathwaysin non-small cell lung cancer cells

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

NF-κB activation induced by chloroquine requires autophagosome, p62, and JNK signaling and promotes tumor cell resistance

Disulfiram combined with copper inhibits metastasis and epithelial–mesenchymal transition in hepatocellular carcinoma through the NF-jB and TGF-b pathways

Evidence for the efficacy of disulfiram and copper combination in glioblastoma multiforme – A propos of a case

Repositionierung von Disulfiram zur Therapie des Ovarialkarzinoms

Disulfiram copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

Disulfiram modulated ROS–MAPK and NFkB pathways and targeted breast cancer cells with cancer stem cell-like properties

Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway

Anticancer adjuvant containing pentoxifylline Patent US 20150374702

Potentiation of Anticancer Drugs: Effects of Pentoxifylline on Neoplastic Cells

Pentoxifylline triggers autophagy via ER stress response that interferes
with Pentoxifylline induced apoptosis in human melanoma cells

Pentoxifylline- rescue for the oncological patient. Anticancer and protective properties of an alkaloid derivative

Disulfiram Induces Apoptosis in Human Melanoma Cells: A Redox-related Process

The Efficacy of Dandelion Root Extract in Inducing Apoptosis in Drug-Resistant Human Melanoma Cells

Ligands for cannabinoid receptors, promising anticancer agents

beta-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

A Brief Overview on Natural Killer Cells

Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK

Lung cancer stem cells: The root of resistance

CANNABIS for the treatment of cancer – The anticancer activity of phytocannabinoids and endocannabinoids – by Justin Kander

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Tumor Growth in Transgenic Apc Min + Mice, Correlating with CB1 Receptor Up-Regulation

Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization

Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil

Oleocanthal Attenuates Cell Proliferation, Invasiveness, and Tumor Growth in Breast Cancer Models

Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma


High‑dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate

Oxidative stress and apoptosis induction in human thyroid carcinoma cells exposed to the essential oil from Pistacia lentiscus aerial parts (Mastic oil)

Epigenetic mechanisms and endocannabinoid signalling

The endocannabinoid signaling system in cancer

In Vitro Investigation of the Potential Immunomodulatory and Anti-Cancer Activities of Black Pepper (Piper nigrum) and Cardamom (Elettaria cardamomum)

Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines

Analyzing bioactive effects of the minor hop compound xanthohumol C on human breast cancer cells using quantitative proteomics

Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines

Oridonin inhibits the proliferation, migration and invasion of human osteosarcoma cells via suppression of matrix metalloproteinase expression and STAT3 signalling pathway

The metabolic advantage of tumor cells


Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo

Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies

Polo-like Kinase 1 inhibition as a therapeutic approach to selectively 1 target BRCA1-deficient cancer cells by synthetic lethality induction

MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression

Inhibition of Tumor Growth by Dietary Indole-3-Carbinol in a Prostate Cancer Xenograft Model May Be Associated with Disrupted Gut Microbial Interactions


Synergistic Anticancer Effects of Silibinin and Chrysin in T47D Breast Cancer Cells


Role of Melatonin in Cancer Treatment

Antihelminthic drugs as a treatment for hyperproliferative diseases

Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects

Cancer stem cells – Road to therapeutic resistance and strategies to overcome resistance

The novel role of pyrvinium in cancer therapy – Pyrvinium and inhibition of Hippo pathway

Inhibitory effect of pyrvinium pamoate on uveal melanoma cells involves blocking of Wnt/β-catenin pathway

Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration

Cytotoxic Effects of Artemisia annua L. and Pure Artemisinin on the D-17 Canine Osteosarcoma Cell Line


Melatonin: An important anticancer agent in colorectal cancer

In vitro investigation of anti-cancer activity of propolis on hepatocellular carcinoma cells

Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines

Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics

Anticancer Activity and Underlying Mechanism of Phytochemicals against Multiple Myeloma

Insights on the Multifunctional Activities of Magnolol

Grape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K Akt signaling pathway

Anti-cancer effects of cinnamon – Insights into its apoptosis effects

Marine Carotenoid Fucoxanthin Possesses Anti-Metastasis Activity – Molecular Evidence

Pharmacoepigenetics of Chinese Herbal Components in Cancer

Suppression of colorectal cancer cell growth by combined treatment of 6‑gingerol and γ‑tocotrienol via alteration of multiple signalling pathways

Natural products for treating colorectal cancer – A mechanistic review

Kaempferol exerts anti-proliferative effects on human ovarian cancer cells by inducing apoptosis, G0 G1 cell cycle arrest and modulation of MEK/ERK and STAT3 pathways

Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR PI3K AKT signalling pathway

Fucoidan from Fucus vesiculosus inhibits new blood vessel formation and breast tumor growth in vivo

Bioactive Compounds and Biological Functions of Garlic (Allium sativum)

Effects of Curcumin on Ion Channels and Pumps

Cardamonin Induces Cell Cycle Arrest, Apoptosis and Alters Apoptosis Associated Gene Expression in WEHI-3 Mouse Leukemia Cells

Honokiol induces apoptosis and suppresses migration and invasion of ovarian carcinoma cells via AMPK/mTOR signaling pathway

Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice – Ivermectin

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage

Cimetidine as an anti-cancer agent

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress

The anti parasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway

Ivermectin as an inhibitor of cancer stem‑like cells

Ivermectin – Old Drug, New Tricks

The multitargeted drug ivermectin – from an antiparasitic agent to a repositioned cancer drug

Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs

Gut microbiota, inflammation and colorectal cancer

Cellular metabolism in colorectal carcinogenesis: Influence of lifestyle, gut microbiome and metabolic pathways

α‑MMC and MAP30, two ribosome‑inactivating proteins extracted from Momordica charantia, induce cell cycle arrest and apoptosis in A549 human lung carcinoma cells

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

Induction of Tumor Cytotoxic Immune Cells Using a Protein from the Bitter Melon (Momordica charantia)

Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways


Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions

Vitamin E – Regulatory Role on Signal Transduction

Natural Forms of Vitamin E and Metabolites – Regulation of Cancer Cell Death and Underlying Mechanisms

Fucoxanthin induces apoptosis in human glioma cells by triggering ROS-mediated oxidative damage and regulating MAPKs and PI3K AKT pathways

Icaritin – A Novel Natural Candidate for Hematological Malignancies Therapy

Albendazole Induces Cell Death in Human Colorectal Cancer Cell Line HT-29

Flubendazole elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition

Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets

Flubendazole inhibits glioma proliferation by G2 M cell cycle arrest and pro-apoptosis

A list of studies about CBD and Cannabinoids–cannabis-studies.html#

More Scientific Studies Proving Cannabis Fights Cancer:

Cannabis can kill cancer cells!

Uterine, testicular, and pancreatic cancers

Brain cancer

Mouth and throat cancer

Breast cancer

Lung cancer

Prostate cancer

Blood cancer

Skin cancer

Liver cancer

Cannabis cancer cures (general)

Cancers of the head and neck

Cholangiocarcinoma cancer


Cannabis partially/fully induced cancer cell death

Translocation-positive rhabdomyosarcoma


Cannabis kills cancer cells


Thyroid carcinoma

Colon cancer

Intestinal inflammation and cancer

Cannabinoids in health and disease

Cannabis inhibits cancer cell invasion